Best Natural St. John's Wort Supplements of 2025

Elisa Drew Avatar
Elisa Drew
Last Updated: Jan 9, 2025

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Natural St. John's Wort supplements are a popular choice for those seeking a natural remedy for mild to moderate depression, anxiety, and seasonal affective disorder. These supplements are derived from the St. John's Wort plant, which has been used for medicinal purposes for centuries. They are known to contain hypericin and hyperforin, which are believed to be the active ingredients responsible for their mood-lifting properties. Natural St. John's Wort supplements are available in various forms, including capsules, tablets, and teas, and are generally considered safe when taken as directed. However, it is important to consult a healthcare practitioner before using these supplements, especially if taking other medications or experiencing severe symptoms.

At a Glance: Our Top Picks

Gaia Herbs St. John's Wort Stress Support Supplement Cover #TOP 1
Gaia Herbs St. John's Wort Stress Support Supplement
ftb score rating icon 9.8
Zazzee Extra Strength St. John’s Wort 20:1 Extract Cover #TOP 2
Zazzee Extra Strength St. John’s Wort 20:1 Extract
ftb score rating icon 9.7
Nature's Way St. John's Wort Cover #TOP 3
Nature's Way St. John's Wort
ftb score rating icon 9.5

Top 10 Natural St. John's Wort Supplements

#TOP 1

Gaia Herbs St. John's Wort Stress Support Supplement

7.51063E+11
Gaia Herbs St. John's Wort Stress Support Supplement Cover
Gaia Herbs St. John's Wort - Natural Stress Support Supplement - with St. John's Wort - 60 Vegan Capsules (20-Day Supply)

Gaia Herbs St. John's Wort is a natural stress support supplement designed to help maintain a balanced mindset and positive outlook. Its potent formula contains St. John's Wort in convenient vegan capsules that can be taken at home or on-the-go. The supplement is gluten-free, vegan, and purity-tested for maximum efficacy. Gaia Herbs is committed to transparency and sustainability, using organic methods to cultivate over 6.5 million plants each year and building strong connections between people, plants, and the planet.

What We Like
Potent formula for stress support
Convenient vegan capsules for on-the-go use
Gluten-free and purity-tested for maximum efficacy
Committed to transparency and sustainability

Zazzee Extra Strength St. John’s Wort 20:1 Extract

Zazzee Extra Strength St. John’s Wort 20:1 Extract Cover
Zazzee Extra Strength St. John’s Wort 20:1 Extract, 8000 mg Strength, 0.3% Hypericin, 150 Vegan Capsules, 5 Month Supply, Concentrated, Standardized 20X Extract, 100% Vegetarian, Non-GMO, All-Natural

Zazzee St. John’s Wort Extract offers exceptional value with 8000 mg strength per capsule and 150 capsules per bottle, providing a 5-month supply. The potent 20:1 extract with 0.3% Hypericin makes it one of the strongest dosages available. Hypericin, the beneficial compound, is standardized to a minimum of 0.3%, ensuring potent results. The product is natural, vegan, and non-GMO, free from harmful additives. Manufactured in the USA under stringent quality control, ensuring the best value for your health.

What We Like
8000 mg strength
20:1 potent extract
0.3% Hypericin

Nature's Way St. John's Wort

Nature's Way
14041
Nature's Way St. John's Wort Cover
Nature's Way St. John’s Wort Herb, Promotes a Positive Outlook*, 700 mg per 2-Capsule Serving, Non-GMO Project Verified, Vegan, 180 Capsules (Packaging May Vary)

Nature's Way Premium Herbal St. John’s Wort Herb is a supplement designed to help promote a positive outlook and support the body's ability to adapt to everyday stress. It is Non-GMO Project Verified, gluten-free, vegan, and free of salt, yeast-derived ingredients, wheat, soy, corn, dairy, or artificial colors, flavors, or preservatives. Adults take 2 capsules twice daily, and for best results, use for at least 2 months. Customer reviews suggest that it can help with mild to moderate depression, anxiety, and brain fog, although it is not FDA approved and should be discussed with a professional.

What We Like
Non-GMO Project Verified, gluten-free, vegan, and free of artificial ingredients
Help promote a positive outlook and support the body's ability to adapt to everyday stress
Can help with mild to moderate depression, anxiety, and brain fog
#TOP 4

Nature's Bounty St. John's Wort Capsules

Nature's Bounty St. John's Wort Capsules Cover
Nature's Bounty St. John’s Wort 300mg Capsules, Herbal Health Supplement, Promotes a Positive Mood, 100 Capsules

Looking for a quality St. John’s Wort supplement for mood support? Nature’s Bounty St. John’s Wort offers the mood support you need to feel calm, relaxed and ready to take on life’s challenges. Trusted for centuries as a tonic and popularly used to promote mental well-being, St. John’s Wort at a daily dose of 900 mg per day can help you maintain a positive mood and healthy emotional outlook. Simply take three capsules of Nature’s Bounty St. John’s Wort per day. Capsules may also be opened and prepared as a soothing tea. Each pack contains 100 capsules.

What We Like
900 mg of St. John's Wort per day is shown to help maintain a positive mood and healthy emotional outlook
Nature's Bounty St. John's Wort supports feelings of tranquility, helping you relax and feel your best
Nature's Bounty uses St. John's Wort Extract that is standardized to contain .3% Hypericin to ensure a high-quality supplement
Non-GMO, gluten free, sugar free and lactose free, with no artificial colors, flavors or sweeteners added
From the trusted vitamin and supplement experts at Nature’s Bounty

Terry Naturally St. John’s Wort 900 mg Tablets

Terry Naturally St. John’s Wort 900 mg Tablets Cover
Terry Naturally St. John’s Wort 900 mg - 60 Tablets - Supports Emotional Health for 24 Hours - Non-GMO, Vegan, Gluten Free - 60 Servings

Terry Naturally St. John’s Wort delivers a full 900 mg dose to support your emotional health for 24 hours. Its once-daily dosing makes it easy to stay consistent. The clinical strength extract features the recommended level of 0.3% hypericin, ensuring lasting benefits. The coated tablets are easier to swallow and minimize any unpleasant odor. With high-quality ingredients and manufacturing standards, Terry Naturally St. John’s Wort is a reliable choice for emotional well-being.

What We Like
24-hour emotional support
Once-daily dosing convenience
Clinical strength extract
#TOP 6

Healths Harmony St. John's Wort

1H-JVTK-OQKE
Healths Harmony St. John's Wort Cover
St. John's Wort - 120 Capsules (Non-GMO) Effective St Johns Wort Capsules - Powerful 900mcg Hypericin - Standardized Extract & Whole Herb Supplement - No Oil, Pills, Tea, Tincture - 500mg Per Capsule

Healths Harmony St. John's Wort is a natural mood helper that provides 900mcg of Hypericin in every serving. It comes in 120 capsules per bottle, with each capsule containing 500mg of St. John's Wort extract. It is manufactured in a GMP-certified facility in the USA using globally sourced ingredients. Customers have reported feeling a sense of calm and reduced anxiety after taking this product, and it has helped some quit nicotine with fewer side effects than other medications.

What We Like
Contains 900mcg of Hypericin per serving
120 capsules per bottle
Manufactured in a GMP-certified facility
Customers have reported feeling a sense of calm and reduced anxiety
Helps some quit nicotine with fewer side effects than other medications
#TOP 7

Joy-Filled Mood Support Supplement

Joy-Filled Mood Support Supplement Cover
Joy-Filled Mood Support Supplement with St. Johns Wort | Stress Relief Supplement - Helps Calm The Mind & Body | 100% Plant-Based, Ashwagandha, Rhodiola Rosea, Eleuthero | Herbal, 60 ct

The Joy-Filled Mood Support Supplement is a 100% plant-based supplement designed to calm the mind and body, relieve stress, and boost mood. Formulated with 7 natural herbs such as Ginkgo Biloba, Rhodiola Rosea, and St. John's Wort, it helps you find inner joy and promotes an overall calming effect. It is vegan, non-GMO, and made with natural ingredients. It also comes with a 60-day return policy for customer satisfaction.

What We Like
Contains 7 natural herbs to promote relaxation and reduce stress
Vegan, non-GMO, and made with natural ingredients
Comes with a 60-day return policy for customer satisfaction

Wild & Organic St Johns Wort Tincture

4 Fl Oz (Pack of 1)
Wild & Organic St Johns Wort Tincture Cover
Wild & Organic St Johns Wort Tincture - St. Johns Wort Herb Supplement for Mood Support - Vegan, Alcohol Free Drops - 4 fl oz

Wild & Organic Tincture is a herbal treasure made from St. John's Wort, known for boosting wellness. Each serving contains 685mg of organic flowering tops extract, free from GMOs, sugar, and artificial ingredients. The liquid drops offer superior absorption, making it easier for you to consume nutrients. Crafted with care, this premium tincture is sourced sustainably and validated by lab tests for your peace of mind. If you're not satisfied, the brand is committed to making it right for you.

What We Like
Wellness-boosting properties
Superior absorption
Purely sourced ingredients
#TOP 9

Eagle Shine Vitamins St. John's Wort Extract

Eagle Shine Vitamins St. John's Wort Extract Cover
DEAL SUPPLEMENT St. John's Wort Extract 1000mg - 240* Capsules, Retains 3000mcg Active Hypericins | Premium North American Source

Eagle Shine Vitamins St. John's Wort Extract offers naturally grown and harvested premium St John's Wort from North America. It provides a potent extract that comes from pure flower heads and provides a minimum standardized 0.3% active hypericin level per serving. Take it in the morning or right before bed to enjoy lasting mental calmness and relaxation. The important active ingredients work to promote mind and body clarity in any situation. Only 2 capsules per serving that will provide an extra strength 1,000mg dose and retains 3,000mcg of active hypericins. Enjoy 240 total capsules which equals up to a 120-day supply. It can be taken daily to recharge your mind and body outlook with natural herbal benefits. Made without gluten, dairy, eggs, peanuts, soy, wheat, yeast, and tree nuts.

What We Like
Naturally grown and harvested premium St John's Wort from North America
Provides a potent extract that comes from pure flower heads and provides a minimum standardized 0.3% active hypericin level per serving
Only 2 capsules per serving that will provide an extra strength 1,000mg dose and retains 3,000mcg of active hypericins
240 total capsules which equals up to a 120-day supply
Made without gluten, dairy, eggs, peanuts, soy, wheat, yeast, and tree nuts
#TOP 10

Blossom Nature St. John's Wort Mood Support Supplement

Blossom Nature St. John's Wort Mood Support Supplement Cover
St Johns Wort 900mg-Mood Support Supplement*-Calm Supplements*-120 Vegetable St Johns Wort Capsules(2 Month Supply),450mg of Vegan, Non-GMO St. John's Wort (Hypericum Perforatum),0.3%Hypericin per Cap

Blossom Nature St. John's Wort Mood Support Supplement is a natural and effective way to balance mood and support emotional wellbeing*. With 900mg of St. John's Wort per serving, each bottle includes 120 vegan, non-GMO capsules for a full 2 month supply. The supplement is manufactured in the USA and is gluten-free. Additionally, Blossom Nature offers a 30-day money back guarantee if the product does not work for you.

What We Like
Natural support for emotional wellbeing and positive mood balance*
900mg of St. John's Wort per serving for a full 2 month supply
Manufactured in the USA and is gluten-free and non-GMO
Buying Guide Image

Frequently Asked Questions (FAQs)

1. Why not to take St John's Wort?

Side effects from St. John's wort are generally mild and include stomach upset, hives or other skin rashes, fatigue, restlessness, headache, dry mouth, and feelings of dizziness or mental confusion. St. John's wort can also make the skin overly sensitive to sunlight, called photodermatitis.

2. Is St John's wort a natural remedy?

The scientific name is Hypericum perforatum. St John's wort is a herbal remedy made from the flowers and unopened buds of the plant. It is a popular complementary therapy for mild to moderate depression. There is some scientific evidence to show that St John's wort can help to reduce mild or moderate depression.

3. What does St John's wort do for the body?

Historically, St. John's wort has been used for a variety of conditions, including kidney and lung ailments, insomnia, and depression, and to aid wound healing.

Editor's Notes

During our natural st. john's wort supplement research, we found 24 natural st. john's wort supplement products and shortlisted 10 quality products. We collected and analyzed 140,506 customer reviews through our big data system to write the natural st. john's wort supplements list. We found that most customers choose natural st. john's wort supplements with an average price of $20.05.

The natural st. john's wort supplements are available for purchase. We have researched hundreds of brands and picked the top brands of natural st. john's wort supplements, including Gaia Herbs, Zazzee, Nature's Way, Nature's Bounty, Terry Naturally. The seller of top 1 product has received honest feedback from 54,877 consumers with an average rating of 4.9.

Written by
Elisa Drew Avatar

Elisa Drew is a really professional copywriter specializing in baby products with five years of experience working as a pediatrician once. She has published a series of baby books purchased by over thirty thousand people in the United States.