Best Tablet Sinus Medicine of 2026

Sudafed Sinus Relief is a maximum strength non-drowsy decongestant tablet that provides fast and powerful relief of sinus pressure and sinus and nasal congestion. It is a nasal decongestant that helps to temporarily relieve nasal congestion associated with hay fever, upper respiratory allergies, and the common cold. With its phenylephrine formula, each tablet contains 10 mg of phenylephrine HCI, offering non-drowsy, fast, and powerful symptom relief. This sinus congestion relief can be used by adults and children ages 12 and up. Take one tablet every 4 hours, but do not exceed 6 tablets within a 24-hour time period. Sudafed Sinus Relief is the #1 pharmacist recommended brand among oral OTC decongestants, making it a reliable choice for relieving sinus and nasal congestion.

Advil Sinus Congestion and Pain is a pain reliever and fever reducer medicine that also provides sinus pressure relief, nasal congestion relief, and nasal swelling relief. Each package comes with 20 coated tablets that are portable and easy to carry around. This sinus medicine is suitable for adults and children who are 12 years and older. It contains ibuprofen 200mg and Phenylephrine HCl 10 mg, and you can take one of these tablets every 4 hours as needed for symptoms.

Sudafed Head Congestion Tablets is a non-drowsy sinus relief medicine that provides relief from sinus pain and pressure, nasal and chest congestion, and excess mucus. With its powerful formula containing phenylephrine HCl, acetaminophen, and guaifenesin, it effectively reduces congestion, relieves pain and fever, and helps to clear bronchial passageways. Whether you're suffering from hay fever, upper respiratory allergies, or the common cold, these tablets can provide temporary relief from symptoms. Say goodbye to sinus pressure, headaches, and minor aches and pains with Sudafed Head Congestion Tablets, the #1 pharmacist recommended brand among oral OTC decongestants.

Sudafed PE Day and Night Sinus Pressure & Congestion Tablets is a powerful formula for relieving sinus pressure and congestion for both day and night. This pack contains 20 tablets of nasal decongestant that can temporarily relieve the symptoms of sinus pressure and sinus congestion. It includes 12 daytime and 8 nighttime tablets with 10 milligrams of the nasal decongestant phenylephrine HCl per tablet. The nighttime dose also contains 25 milligrams per tablet of antihistamine diphenhydramine HCl that can relieve sneezing, runny nose, itchy, watery eyes and itchy throat or nose. This maximum-strength formula can be used by adults and children 12 years and older.

Vicks Sinex SEVERE Nasal Spray targets nasal congestion and sinus pressure, providing 12-hour relief from stuffy nose due to cold or allergy. It works by reducing swelling in the sinuses and delivering powerful decongestant medicine directly to the nasal membranes, making it more effective than nasal decongestant tablets. It's not intended for daily use and is HSA and FSA eligible.

GenCare Nasal Decongestant Tablets offer ultimate sinus relief by providing maximum strength nasal decongestion and sinus pressure relief from indoor or outdoor allergies or common cold symptoms. The non-drowsy formula can be taken any time of day and the bulk savings bottle is perfect for families or those who suffer from chronic congestion due to allergies or seasonal illness. The 100% satisfaction guarantee ensures ultimate convenience and customer satisfaction.

For quick relief from nasal congestion, Vicks Sinex Nasal Spray is an excellent choice. It works rapidly, clearing your stuffy nose in seconds, making it six times faster than traditional decongestant tablets. You can enjoy up to 12 hours of relief, allowing you to breathe comfortably both day and night. This spray specifically targets the source of your congestion, helping you feel better faster. Additionally, the soothing Vicks vapors provide a comforting sensation, enhancing your overall experience while using the product.

Advil Sinus Congestion and Pain Relief Medicine is a combination of ibuprofen and phenylephrine HCl that provides temporary relief from fever, minor body aches, headache, sinus pressure, nasal congestion, and nasal swelling. The coated tablets are portable and easy to carry, making it a perfect on-the-go solution. It is suitable for adults and children aged 12 years and older. This product comes with single dose packets and is HSA and FSA eligible.

The ValuMeds Nasal Decongestant offers strong, non-drowsy relief from sinus pressure and nasal congestion, so you can breathe easier without feeling sleepy. It helps reduce swelling in your nasal passages, which improves airflow and eases sinus headaches and stuffiness caused by colds or allergies. This medicine contains the same active ingredient as Sudafed PE, providing reliable congestion relief at a better price. Because it’s non-drowsy, you can take it during the day at work, school, or while traveling, staying alert and productive even when dealing with congestion or sinus discomfort.

The NUVICARE Max Strength Decongestant offers strong relief from nasal congestion with 10mg of phenylephrine HCl, which helps shrink swollen blood vessels in your nose for easier breathing. These small, easy-to-swallow tablets work quickly to clear your sinuses, making it simpler to breathe deeply and comfortably throughout the day and night. Unlike many sinus medicines that make you sleepy, this non-drowsy formula keeps you alert and active, so you can continue your daily activities without interruption. If you want a powerful, convenient way to relieve sinus pressure and congestion, this product is designed to help you feel better fast.