Best Sinus Medicine of 2025

Amazon Saline Nasal Spray is designed to help you find relief from dry nasal passages. It contains a blend of sodium chloride and preservatives to keep your nasal membranes moist. This non-medicated spray is perfect for soothing irritation caused by allergies, sinus issues, or colds. You can use it whenever you need instant hydration for your nose, making it a convenient solution for maintaining comfort throughout your day. Just remember to keep it out of reach of children and avoid sharing it to prevent any potential infections.

Sudafed PE Sinus Pressure + Pain Relief Maximum Strength Non-Drowsy Decongestant contains 24 caplets that provide powerful relief of sinus pain, sinus pressure, nasal congestion, headaches, and fever. Each caplet contains 5mg phenylephrine HCl and 325mg acetaminophen, and can also relieve nasal congestion associated with hay fever, respiratory allergies, and the common cold. The non-drowsy decongestant promotes sinus drainage, reduces fever, and helps relieve headaches and minor aches and pain. This maximum strength formula is recommended by pharmacists for adults and children over 12 years old.

Vicks Sinex SEVERE provides quick relief for sinus symptoms including congestion, pressure, headache, pain, and mucus. The non-drowsy formula is effective for sinus symptoms caused by allergies or the common cold, and it thins and loosens mucus while reducing pressure in the sinuses. This product is HSA and FSA eligible, but it does not contain antihistamine allergy medicine and is not intended for runny nose, itchy or watery eyes, or sneezing.

Get maximum strength relief from severe congestion and pain with Mucinex Sinus-Max Severe Congestion Relief Caplets. This cold and cough brand is trusted by doctors and helps relieve chest congestion, nasal congestion, sinus congestion, headache, and pain. It contains Acetaminophen for minor aches and pains, Guaifenesin that thins and loosens mucus, and Phenylephrine HCl that provides relief for nasal and sinus congestion. Suitable for ages 12 and above.

Advil Sinus Relief Medicine is a pain reliever and fever reducer with ibuprofen and phenylephrine HCl. It comes in a package of 10 coated tablets, making it easy to carry around and use whenever you need it. The ibuprofen helps to temporarily relieve fever, minor body aches and headache. The phenylephrine HCl tablets provide relief from sinus pressure, nasal congestion, and nasal swelling. This daytime or nighttime sinus medicine is suitable for adults and children aged 12 years and older. Take one of these sinus decongestant tablets every 4 hours as needed for symptoms.

Tylenol Sinus + Headache Daytime Caplets are formulated to temporarily relieve symptoms of nasal congestion, sinus headache, and pressure. Each caplet contains 325 mg of acetaminophen and 5 mg of phenylephrine HCl, which helps clear nasal passages. The non-drowsy formula promotes sinus drainage and decongests sinus openings and passages, providing effective daytime symptom relief. Suitable for adults and children ages 12 years and older, this sinus medicine is doctor-recommended.

Tylenol Sinus Severe Daytime Caplets provide non-drowsy relief for symptoms caused by the common cold, hay fever or other respiratory allergies. Each caplet contains acetaminophen, a pain reliever and fever reducer, nasal decongestant phenylephrine HCl, and expectorant guaifenesin to help make coughs more productive. This sinus medicine promotes sinus drainage and decongests sinus openings, suitable for adults and children ages 12 years and older.

Vicks Sinex SEVERE Nasal Spray targets nasal congestion and sinus pressure, providing 12-hour relief from stuffy nose due to cold or allergy. It works by reducing swelling in the sinuses and delivering powerful decongestant medicine directly to the nasal membranes, making it more effective than nasal decongestant tablets. It's not intended for daily use and is HSA and FSA eligible.

Sudafed Head Congestion Tablets is a non-drowsy sinus relief medicine that provides relief from sinus pain and pressure, nasal and chest congestion, and excess mucus. With its powerful formula containing phenylephrine HCl, acetaminophen, and guaifenesin, it effectively reduces congestion, relieves pain and fever, and helps to clear bronchial passageways. Whether you're suffering from hay fever, upper respiratory allergies, or the common cold, these tablets can provide temporary relief from symptoms. Say goodbye to sinus pressure, headaches, and minor aches and pains with Sudafed Head Congestion Tablets, the #1 pharmacist recommended brand among oral OTC decongestants.

Relieve sinus pressure, pain, congestion, cough, runny nose, sore throat, and more with Mucinex Maximum Strength Sinus-Max Day and Night Caplets. The day caplets provide fast, powerful relief for daytime symptoms such as headaches, while the night caplets offer nighttime relief for better sleep. Both caplets contain active ingredients like acetaminophen, cough suppressant, nasal decongestant, and more. Mucinex is a brand that doctors trust, and the product is FSA and HSA eligible.