Best Spray Sinus Medicine of 2026

Vicks Sinex SEVERE Nasal Spray targets nasal congestion and sinus pressure, providing 12-hour relief from stuffy nose due to cold or allergy. It works by reducing swelling in the sinuses and delivering powerful decongestant medicine directly to the nasal membranes, making it more effective than nasal decongestant tablets. It's not intended for daily use and is HSA and FSA eligible.

Amazon Saline Nasal Spray is designed to help you find relief from dry nasal passages. It contains a blend of sodium chloride and preservatives to keep your nasal membranes moist. This non-medicated spray is perfect for soothing irritation caused by allergies, sinus issues, or colds. You can use it whenever you need instant hydration for your nose, making it a convenient solution for maintaining comfort throughout your day. Just remember to keep it out of reach of children and avoid sharing it to prevent any potential infections.

The NOVEHA Iodine Nasal Spray offers effective relief by cleansing and refreshing your nasal passages, helping to clear congestion and improve airflow for daily comfort. It acts as your first line of defense by gently cleansing and hydrating your nose, supporting easier breathing and natural protection against airborne irritants. Made with natural ingredients like Povidone Iodine and Aloe Vera, this spray is gentle enough for everyday use, ensuring your nasal passages stay healthy without causing dryness or irritation. Plus, it provides fast-acting relief that can last up to 12 hours, keeping your sinuses clear and comfortable throughout the day.

Xlear Nasal Spray with Xylitol is a natural saline solution that gently cleans and moisturizes sinus tissues. It can decongest the sinuses by targeting the primary causes of nasal congestion, including pollen, pollution, contaminants, and other irritants. The patented saline nasal spray solution has an improved formula with xylitol that reduces tissue inflammation and opens airways. The product is easy to use, safe for kids, non-addictive, and non-GMO verified. Each 1.5 oz bottle delivers approx. 240 fine mist sprays to wash away pollutants and bring sinus relief.

FridaBaby Saline Spray is a natural sea salt and purified water solution that is specially formulated for small noses. This 20 ml spray provides non-medicated relief for stubborn boogies and stuffy noses while also moisturizing nasal passages. The small applicator tip is designed for tiny nostrils, making it easy to remove mucus and clean nasal passageways. When used with Frida Baby's Nasal Aspirator NoseFrida The Snotsucker (not included), it provides seamless snotsucking. The spout works for both spray and drop application. It has no alcohol, medicine, or other additives, making it safe for your little one.

Amazon Basic Care Nasal Spray is a powerful decongestant that provides fast and long-lasting relief from nasal congestion caused by allergies, colds, and sinus issues. With its active ingredient, oxymetazoline hydrochloride, this nasal spray effectively clears stuffy nose and relieves sinus pressure for up to 12 hours. Whether you are suffering from the common cold, hay fever, or upper respiratory allergies, this nasal spray can provide you with quick relief. Its fast-acting formula ensures that you can breathe freely and comfortably, helping you to go about your day without any discomfort. Say goodbye to nasal congestion with Amazon Basic Care Nasal Spray.

The ARM & HAMMER Saline Nasal Mist offers quick relief from everyday nasal congestion, helping you breathe easier when allergies or colds strike. This gentle spray moisturizes dry nasal passages, which can prevent discomfort and nosebleeds. It works fast by flushing out irritants like dust and pollen, providing natural congestion relief without any harsh chemicals. Made with just purified water, salt, and real ARM & HAMMER Baking Soda, it’s free from fragrances and artificial additives, making it a safe and soothing choice for your daily nasal care routine.

The Little Remedies Saline Spray is designed to help clear your baby's stuffy or dry nose gently and effectively. It flushes out mucus to ease breathing and keeps your little one's nose moisturized, which can be especially helpful during colds or allergies. This nasal spray is free from alcohol, drugs, and preservatives, making it a safe choice for newborns and young children. You can use it as a dropper or a gentle spray, providing flexible options to relieve your child's nasal discomfort with ease and care.

For quick relief from nasal congestion, Vicks Sinex Nasal Spray is an excellent choice. It works rapidly, clearing your stuffy nose in seconds, making it six times faster than traditional decongestant tablets. You can enjoy up to 12 hours of relief, allowing you to breathe comfortably both day and night. This spray specifically targets the source of your congestion, helping you feel better faster. Additionally, the soothing Vicks vapors provide a comforting sensation, enhancing your overall experience while using the product.

The Amazon Basic Care Nasal Spray is designed to quickly ease your nasal congestion from colds, allergies, or hay fever. It contains oxymetazoline HCl, a top-rated ingredient trusted by many doctors for effective relief. You can count on it to provide up to 12 hours of strong congestion relief, so you breathe easier throughout the day or night. Plus, this spray works fast to reduce sinus pressure and swelling, helping you feel more comfortable quickly. Its no-drip formula means the spray stays where it should, avoiding any mess or discomfort in your nose or throat.