Best Acetaminophen Sinus Medicine of 2026

Tylenol Cold + Flu Severe Day & Night Caplets are formulated to provide multi-symptom relief for cold and flu symptoms. The 24-count combo pack includes 16 Daytime and 8 Nighttime caplets that help reduce fever, relieve headache, body aches, cough, sore throat, nasal congestion, chest congestion, runny nose, sneezing, sinus congestion, and pressure. Each caplet contains acetaminophen, a pain reliever and fever reducer, and other active ingredients such as a nasal decongestant, cough suppressant, antihistamine, and expectorant. This product is from the #1 doctor recommended pain relief brand.

Sudafed PE Sinus Pressure + Pain Relief Maximum Strength Non-Drowsy Decongestant contains 24 caplets that provide powerful relief of sinus pain, sinus pressure, nasal congestion, headaches, and fever. Each caplet contains 5mg phenylephrine HCl and 325mg acetaminophen, and can also relieve nasal congestion associated with hay fever, respiratory allergies, and the common cold. The non-drowsy decongestant promotes sinus drainage, reduces fever, and helps relieve headaches and minor aches and pain. This maximum strength formula is recommended by pharmacists for adults and children over 12 years old.

Tylenol Sinus + Headache Daytime Caplets are formulated to temporarily relieve symptoms of nasal congestion, sinus headache, and pressure. Each caplet contains 325 mg of acetaminophen and 5 mg of phenylephrine HCl, which helps clear nasal passages. The non-drowsy formula promotes sinus drainage and decongests sinus openings and passages, providing effective daytime symptom relief. Suitable for adults and children ages 12 years and older, this sinus medicine is doctor-recommended.

Sudafed Head Congestion Tablets is a non-drowsy sinus relief medicine that provides relief from sinus pain and pressure, nasal and chest congestion, and excess mucus. With its powerful formula containing phenylephrine HCl, acetaminophen, and guaifenesin, it effectively reduces congestion, relieves pain and fever, and helps to clear bronchial passageways. Whether you're suffering from hay fever, upper respiratory allergies, or the common cold, these tablets can provide temporary relief from symptoms. Say goodbye to sinus pressure, headaches, and minor aches and pains with Sudafed Head Congestion Tablets, the #1 pharmacist recommended brand among oral OTC decongestants.

Tylenol Sinus Severe Daytime Caplets are perfect for those who need non-drowsy pain and congestion relief. Each pack contains 50 travel-sized packs of two caplets, making them perfect for use both at home and on-the-go. The caplets contain acetaminophen to relieve pain and reduce fever, guaifenesin to make coughs more productive, and phenylephrine HCl to clear nasal passages. This sinus medicine is recommended for adults and children over 12 years old.

Mucinex Rapid Clear Cold Relief offers powerful relief from common cold and flu symptoms. It contains acetaminophen, which helps lower fever and eases body aches and headaches, so you can feel more comfortable. The expectorant guaifenesin works to thin and loosen mucus in your chest, making it easier to cough up and clear congestion. This combination helps reduce discomfort from excess mucus and headache, allowing you to get back to your day without the usual cold-related struggles. With fast-acting liquid gels, this medicine provides quick and effective relief when you need it most.

Mucinex is a trusted brand of sinus medicine that doctors and pharmacists recommend. It offers maximum strength relief for severe congestion and pain. This pack includes two 6 Fl Oz bottles of Mucinex Maximum Strength Sinus-Max Severe Congestion & Pain and Nightshift Sinus Liquid.

AXIV Sinus Relief offers fast and powerful help for those suffering from sinus pressure, headaches, and nasal congestion. If you need quick relief, this product combines acetaminophen, a trusted painkiller, with phenylephrine, a nasal decongestant, to ease your symptoms and help you breathe better. It works on multiple discomforts caused by colds, sinus infections, or allergies, giving you a break from headaches and facial pressure. Plus, it won’t make you feel sleepy, so you can use it during the day without worries. With easy-to-swallow softgels, it’s a convenient choice for quick sinus symptom relief.

Mucinex Rapid Clear Cold Relief offers fast and effective relief from common cold and flu symptoms. The daytime liquid gels help reduce fever, body aches, and headaches, so you can feel better and stay productive during the day. These gels also contain an expectorant that thins mucus, making it easier to cough up and clear your chest congestion. The nighttime liquid gels are designed to ease symptoms like fever, body pain, cough, and nasal irritation, helping you rest comfortably through the night. This combination ensures that you get relief both day and night, making it easier to manage your cold symptoms and get back to your routine.

Get relief from hay fever or other respiratory allergies, and the common cold with Tylenol Sinus Congestion & Pain Severe Caplets. This pack of 3 includes 24 caplets in each pack, providing temporary relief from sinus congestion and pressure, headache, nasal congestion, and minor aches and pains. This sinus medicine is perfect for those who want to stay active throughout the day without feeling drowsy.