Best Acetaminophen Sinus Medicine of 2025

Tylenol Sinus + Headache Daytime Caplets are formulated to temporarily relieve symptoms of nasal congestion, sinus headache, and pressure. Each caplet contains 325 mg of acetaminophen and 5 mg of phenylephrine HCl, which helps clear nasal passages. The non-drowsy formula promotes sinus drainage and decongests sinus openings and passages, providing effective daytime symptom relief. Suitable for adults and children ages 12 years and older, this sinus medicine is doctor-recommended.

Rite Aid Severe Sinus Congestion & Pain Relief is a multi-symptom non-drowsy sinus medicine for adults. Each caplet contains 325mg of Acetaminophen, which can temporarily relieve common cold symptoms like fever, headache, sore throat, and aches. The expectorant and nasal decongestant can help clear mucus and nasal congestion. The medicine is formulated without ingredients that may cause drowsiness, so you can take it during the day. You can trust Rite Aid, a brand that has been providing health and wellness solutions since 1962.

Get maximum strength relief from severe congestion and pain with Mucinex Sinus-Max Severe Congestion Relief Caplets. This cold and cough brand is trusted by doctors and helps relieve chest congestion, nasal congestion, sinus congestion, headache, and pain. It contains Acetaminophen for minor aches and pains, Guaifenesin that thins and loosens mucus, and Phenylephrine HCl that provides relief for nasal and sinus congestion. Suitable for ages 12 and above.

Tylenol Sinus Severe Daytime Caplets provide non-drowsy relief for symptoms caused by the common cold, hay fever or other respiratory allergies. Each caplet contains acetaminophen, a pain reliever and fever reducer, nasal decongestant phenylephrine HCl, and expectorant guaifenesin to help make coughs more productive. This sinus medicine promotes sinus drainage and decongests sinus openings, suitable for adults and children ages 12 years and older.

Tylenol Sinus is a non-drowsy daytime caplet that provides relief for sinus symptoms and headache pain caused by the common cold, hay fever, or other respiratory allergies. With 24 caplets in a box, this sinus medicine is formulated to temporarily relieve nasal congestion, sinus headache, and pressure. Each caplet contains 325 mg of acetaminophen to reduce pain and fever, as well as 5 mg of phenylephrine HCl, a nasal decongestant that helps clear nasal passages. The non-drowsy formula promotes sinus drainage and decongests sinus openings and passages, ensuring effective daytime relief. Recommended by doctors, Tylenol Sinus is suitable for adults and children aged 12 years and older.

Sudafed PE Sinus Pressure + Pain Relief Maximum Strength Non-Drowsy Decongestant contains 24 caplets that provide powerful relief of sinus pain, sinus pressure, nasal congestion, headaches, and fever. Each caplet contains 5mg phenylephrine HCl and 325mg acetaminophen, and can also relieve nasal congestion associated with hay fever, respiratory allergies, and the common cold. The non-drowsy decongestant promotes sinus drainage, reduces fever, and helps relieve headaches and minor aches and pain. This maximum strength formula is recommended by pharmacists for adults and children over 12 years old.

Rite Aid Maximum Strength Sinus Pressure & Pain Relief is a non-drowsy cold medicine that provides temporary relief from minor aches and pains, nasal congestion, headache, sinus congestion and pressure, fever, and promotes sinus drainage. The multi-symptom relief formula is designed to alleviate symptoms associated with hay fever or other respiratory allergies and the common cold. The allergy and cold medicine is formulated without ingredients that may cause drowsiness. Rite Aid Sinus Pressure & Pain Relief is a trusted brand since 1962.

Rite Aid Maximum Strength Sinus Relief Medicine offers temporary relief from common cold symptoms like nasal congestion, headache, sore throat, fever, and minor aches and pains. It contains expectorant and nasal decongestant to clear mucus and promote nasal/sinus drainage. This cold medicine helps to loosen phlegm and thin bronchial secretions to rid the bronchial passageways of bothersome mucus and make coughs more productive. It is suitable for severe sinus symptoms and has been a trusted brand since 1962.

Tylenol Sinus Caplets offer effective relief from the discomfort of colds and allergies. Each caplet combines 325 mg of acetaminophen for pain and fever reduction, ensuring you feel better fast. With 5 mg of phenylephrine HCl, these caplets help clear nasal passages, making breathing easier. Plus, they contain 200 mg of guaifenesin, which supports productive coughing by thinning mucus. This non-drowsy formula is perfect for daytime use, allowing you to stay focused and active while combating sinus headaches, chest congestion, and more.

Sudafed Head Congestion Tablets is a non-drowsy sinus relief medicine that provides relief from sinus pain and pressure, nasal and chest congestion, and excess mucus. With its powerful formula containing phenylephrine HCl, acetaminophen, and guaifenesin, it effectively reduces congestion, relieves pain and fever, and helps to clear bronchial passageways. Whether you're suffering from hay fever, upper respiratory allergies, or the common cold, these tablets can provide temporary relief from symptoms. Say goodbye to sinus pressure, headaches, and minor aches and pains with Sudafed Head Congestion Tablets, the #1 pharmacist recommended brand among oral OTC decongestants.