Best Vitamin B12 Supplements for Heart Health of 2025

Elisa Drew Avatar
Elisa Drew
Last Updated: Jan 8, 2025

* We independently evaluate all recommended products and services. If you click on links we provide, we may receive compensation.

Vitamin B12 supplements have been found to have potential benefits for heart health. This essential nutrient plays a crucial role in the formation of red blood cells and the maintenance of a healthy nervous system. In addition, studies have suggested that Vitamin B12 may help to lower levels of homocysteine, an amino acid that has been linked to an increased risk of heart disease. For those who don't consume enough Vitamin B12 through their diet, supplements can be a convenient and effective way to ensure adequate intake. It's important to talk to a healthcare provider before starting any new supplement regimen.

At a Glance: Our Top Picks

Life Extension BioActive Folate & Vitamin B12 Capsules Cover #TOP 1
Life Extension BioActive Folate & Vitamin B12 Capsules
ftb score rating icon 9.9
Thorne Vitamin B12 Capsules Cover #TOP 2
Thorne Vitamin B12 Capsules
ftb score rating icon 9.8
Nature’s Bounty Vitamin B12 2500 mcg Tablets Cover #TOP 3
Nature’s Bounty Vitamin B12 2500 mcg Tablets
ftb score rating icon 9.6

Top 10 Vitamin B12 Supplements for Heart Health

Life Extension BioActive Folate & Vitamin B12 Capsules

01842
White
Life Extension BioActive Folate & Vitamin B12 Capsules Cover
Life Extension BioActive Folate & Vitamin B12, Promotes Heart, Brain & GI Tract Health, Non-GMO, Gluten-Free, Vegetarian, 90 Capsules

Life Extension Folate & B12 Capsules promote heart, brain, and GI tract health. The 5-MTHF in the body supports healthy DNA function and immune function. Vitamin B12, in its active form methylcobalamin, aids cognitive health and nerve cell growth. These biologically active forms of B9 and B12 ensure you get the benefits of these essential vitamins. With non-GMO, gluten-free ingredients manufactured in the USA, you can trust the quality and purity of each capsule.

What We Like
Supports healthy DNA function
Cognitive health benefits
Non-GMO and gluten-free

Thorne Vitamin B12 Capsules

B125
Thorne Vitamin B12 Capsules Cover
THORNE Vitamin B12 - as Methylcobalamin - Supports Heart and Nerve Health, Blood Cell Function, Healthy Sleep, and Methylation - Gluten-Free, Soy-Free, Dairy-Free - 60 Capsules

Thorne B12 is a vitamin B12 supplement that comes in capsule form. It contains Methyl-B12, a form of vitamin B12 that is easily absorbed by the body. Thorne B12 supports heart health and nerve function, helps maintain normal circadian rhythms to support restful sleep, and supports the body's healthy methylation processes. The supplement is gluten-free, soy-free, and dairy-free. Thorne is a trusted brand, chosen by champions and trusted by 100+ pro teams. Thorne is the only supplement manufacturer to collaborate with Mayo Clinic on wellness research and content. Thorne is also a proud partner of U.S. Olympic Teams. With Thorne B12, you can improve your heart and nerve health, sleep better, and support your body's natural processes.

What We Like
Easily absorbed Methyl-B12
Gluten-free, soy-free, dairy-free
Supports heart and nerve health
Helps maintain restful sleep
Supports healthy methylation processes

Nature’s Bounty Vitamin B12 2500 mcg Tablets

58911
Green
Nature’s Bounty Vitamin B12 2500 mcg Tablets Cover
Nature’s Bounty Vitamin B12 2500 mcg, Cellular Energy Support, For Energy Metabolism, Heart & Nervous System Health, 75 Quick Dissolve Tablets

Nature’s Bounty Vitamin B12 2500 mcg Tablets are designed to help support your body’s energy metabolism, heart and nervous system health. With 75 quick dissolve tablets, this supplement is an easy and convenient way to ensure that your body gets the Vitamin B12 that it needs. Nature's Bounty is committed to quality and safety and this supplement is gluten-free, sugar-free, and contains no artificial flavors or sweeteners, making it suitable for vegetarians.

What We Like
Supports energy metabolism
Supports heart and circulatory system health
Helps maintain healthy nerve cells and supports nervous system health
Quick dissolve tablets for easy consumption
Gluten-free, sugar-free, and contains no artificial flavors or sweeteners

Vitamatic Folic Acid B12 B6

810078473275
Vitamatic Folic Acid B12 B6 Cover
Vitamatic Folic Acid B12 B6 - Heart Health, Energy & Red Blood Cell Support - 180 Fast Dissolve Tablets

Vitamatic Folic Acid B12 B6 is a dietary supplement that supports heart health, energy, and red blood cell production. Made with folic acid, vitamin B12, and vitamin B6, this non-GMO formula is gluten-free and free of sugar, starch, soy, yeast, corn, wheat, egg, artificial color, flavor, and preservatives. With its fast-dissolve tablets, it offers convenience and ease of use. By taking Vitamatic Folic Acid, you can support your heart health, boost your energy levels, and promote the production of red blood cells. Made in the USA with strict GMP standards, this supplement ensures quality and effectiveness.

What We Like
Heart Health Support
Energy Boost
Red Blood Cell Production
#TOP 5

Puritans Pride Vitamin B-12 1000 Mcg Timed Release Caplets

Puritan's Pride
B004R68LX6
Puritans Pride Vitamin B-12 1000 Mcg Timed Release Caplets Cover
Puritan's Pride Timed Release Vitamin B-12 1000mcg, Vegetarian Dietary Supplement for Energy Metabolism, Heart, Circulatory, and Nervous System Health Support, 8 Month Supply, 250 Caplets

Puritans Pride Vitamin B-12 1000 Mcg Timed Release Caplets is a scientifically formulated vitamin supplement that aids in converting food into energy. It is gluten and soy-free and provides an 8-month supply. Customers are advised to be available during product delivery to avoid damage caused by heat or sunlight. Products may arrive warm during summer, but Amazon stores and ships them accordingly.

What We Like
Scientifically formulated
Aids in converting food into energy
Gluten and soy-free
8-month supply

NATURELO Vegan B12 with Organic Spirulina

VEGAN-B12-90
NATURELO Vegan B12 with Organic Spirulina Cover
NATURELO Vegan B12 - Methyl B12 with Organic Spirulina - High Potency Vitamin B12 1000 mcg Methylcobalamin - Supports Healthy Mood, Energy, Heart & Eye Health - 90 Capsules

The NATURELO Vegan B12 with Organic Spirulina is a high-potency supplement that provides a perfect source of vitamin B12 for vegans and vegetarians. It contains a potent and bioactive 1000 mcg dose of vitamin B12 as methylcobalamin, which the body can use directly without conversion. The addition of organic spirulina, a rich, plant-based source of natural B vitamins, protein, and minerals, makes this supplement a great choice for those who are low in these nutrients as well. Vitamin B12 is essential for energy production, healthy brain and nervous system function, healthy methylation and DNA, and balanced homocysteine levels, which is important for heart health. This premium-quality supplement is non-GMO, gluten-free, soy-free, vegan, and vegetarian, with no coloring, flavoring, or preservatives, making it a great choice for those with dietary restrictions.

What We Like
Provides a high-potency dose of vitamin B12 as methylcobalamin, which the body can use directly without conversion.
Contains organic spirulina, a rich, plant-based source of natural B vitamins, protein, and minerals like copper and iron.
Essential for energy production, healthy brain and nervous system function, healthy methylation and DNA, and balanced homocysteine levels, which is important for heart health.
Premium quality, non-GMO, gluten-free, soy-free, vegan, and vegetarian, with no coloring, flavoring, or preservatives.
A great choice for vegans, vegetarians, and those with dietary restrictions.
#TOP 7

Seeking Health B12 with Folinic Acid - 60 Lozenges

HB12FA-60-LOZ-A
Seeking Health B12 with Folinic Acid - 60 Lozenges Cover
Seeking Health Hydroxo B12 with Folinic Acid - Supplement with Non-Methylated Form of Folate - Vitamin B12 Complex for Heart Health Support - 60 Lozenges

Seeking Health B12 Lozenges are packed with features to support your health. Infused with folinic acid, they aid in DNA repair and methylation processes. This B-complex rich supplement is great for heart health and blood cells. Additionally, it provides support for methylation, energy, and brain health. The allergen-friendly formula ensures you can enjoy heart support without worrying about GMOs or gluten. Seeking Health prioritizes quality and safety, making these lozenges a trustworthy choice for optimizing your healthy living.

What We Like
Heart health support
B-complex rich
Methylation and brain support
#TOP 8

Superior Source No Shot Vitamin B12 Methylcobalamin Sublingual Tablets

076635907007
Superior Source No Shot Vitamin B12 Methylcobalamin Sublingual Tablets Cover
Superior Source No Shot Vitamin B12 Methylcobalamin (1000 mcg), B6, Folic Acid, Quick Dissolve MicroLingual Tablets, 60 Ct, Increase Energy, Healthy Heart, Boost Metabolism, Stress Support, Non-GMO

Superior Source No Shot Vitamin B12 Methylcobalamin Sublingual Tablets provide a quick dissolve solution for increased energy, healthy heart, and metabolism boost. The combination of vitamin B12 (1000 mcg), Folic Acid (800 mcg), and vitamin B6 (2 mg) supports cell production, brain health, and energy metabolism. The product is Non-GMO, gluten-free, preservative-free, sugar-free, and dye-free with no fillers, additives, or excipients. The MicroLingual Vitamins melt instantly under the tongue and provide maximum absorption for the body. The product is GMP certified for quality assurance and the company has been producing pure MicroLingual vitamins since 1998.

What We Like
Quick dissolve sublingual tablets
Non-GMO, gluten-free, preservative-free, sugar-free, and dye-free
MicroLingual Vitamins provide maximum absorption for the body

Nature's Bounty Vitamin B12 Sublingual Liquid

18187
White
2 Fl Oz (Pack of 1)
Nature's Bounty Vitamin B12 Sublingual Liquid Cover
Nature's Bounty Vitamin B12 5000 Mcg Sublingual Liquid, Cardiovascular Health & Cellular Energy Support, 2 Fl Oz (1 Count)

Nature's Bounty Vitamin B12 Sublingual Liquid is an easy-to-take supplement that supports cellular energy and heart health. It contains 5000 mcg of Vitamin B12 per serving, which helps convert food into energy that your body needs. Additionally, Vitamin B12 is important for maintaining healthy nerve cells and supporting the cardiovascular and circulatory systems. This gluten-free and sugar-free liquid has a natural berry flavor and is suitable for vegetarians. Nature's Bounty has nearly 50 years of experience in producing high-quality vitamins and nutritional supplements.

What We Like
Supports cellular energy and heart health
Easy-to-take sublingual liquid with natural berry flavor
Gluten-free, sugar-free, and suitable for vegetarians
#TOP 10

aSquared Nutrition Vitamin B12 - 5000 MCG Supplement

aSquared Nutrition Vitamin B12 - 5000 MCG Supplement Cover
aSquared Nutrition Vitamin B12-5000 MCG Supplement with Methylcobalamin (Methyl B-12) - Max Strength Vitamin B 12 Support to Help Boost Natural Energy, Benefit Brain & Heart Function - 120 Tablets

aSquared Nutrition Vitamin B12 - 5000 MCG Supplement is a high potency and high supply supplement that contains 5000mcg per tablet and 120 tablets for a full 120 day supply. It helps in converting fats, carbs, and proteins into energy more efficiently, improves energy, supports a strong nervous system, and reduces overall fatigue. It also helps in improving brain function, maintaining healthy brain cells, and relieving stomach problems. The supplement is safe and of top quality formation with no citric acid or xylitol to upset your stomach.

What We Like
High potency and high supply
Helps in converting fats, carbs, and proteins into energy more efficiently
Improves energy, supports a strong nervous system, and reduces overall fatigue
Helps in improving brain function, maintaining healthy brain cells, and relieving stomach problems
Safe and of top quality formation with no citric acid or xylitol to upset your stomach
Buying Guide Image

Frequently Asked Questions (FAQs)

1. Is vitamin B12 good for heart health?

May Improve Heart Health by Decreasing Homocysteine If you're significantly deficient in vitamin B12, your homocysteine levels become elevated. Studies have shown that vitamin B12 helps decrease homocysteine levels, which may reduce your risk of heart disease ( 20 , 21 , 22 ).

2. Can B12 affect your heart?

Macrocytosis associated with vitamin B12 deficiency is also associated with fatal and non-fatal coronary disease, myocardial infarction, stroke, and other circulatory health problems.

3. Can a B12 supplement be harmful?

When taken at appropriate doses, vitamin B-12 supplements are generally considered safe. While the recommended daily amount of vitamin B-12 for adults is 2.4 micrograms, higher doses have been found to be safe. Your body absorbs only as much as it needs, and any excess passes through your urine.

4. Who should not take B12 vitamins?

Who should not take VITAMIN B-12?. low amount of potassium in the blood.Leber's hereditary optic atrophy.inflammation of the stomach called atrophic gastritis.past history of complete removal of stomach.

Editor's Notes

During our vitamin b12 supplement for heart health research, we found 24 vitamin b12 supplement for heart health products and shortlisted 10 quality products. We collected and analyzed 270,768 customer reviews through our big data system to write the vitamin b12 supplements for heart health list. We found that most customers choose vitamin b12 supplements for heart health with an average price of $19.92.

The vitamin b12 supplements for heart health are available for purchase. We have researched hundreds of brands and picked the top brands of vitamin b12 supplements for heart health, including Life Extension, THORNE, Nature's Bounty, Vitamatic, Puritan's Pride. The seller of top 1 product has received honest feedback from 385 consumers with an average rating of 4.7.

Written by
Elisa Drew Avatar

Elisa Drew is a really professional copywriter specializing in baby products with five years of experience working as a pediatrician once. She has published a series of baby books purchased by over thirty thousand people in the United States.