Best Chondroitin & Glucosamine Combination Supplements of 2026

Elisa Drew Avatar
Elisa Drew
Last Updated: Jan 10, 2026

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Chondroitin and Glucosamine Combination Supplements are a popular choice for those seeking relief from joint pain and stiffness. These supplements are made up of two key ingredients: chondroitin sulfate and glucosamine hydrochloride. Chondroitin helps to reduce inflammation in the joints, while glucosamine helps to rebuild cartilage and reduce joint pain. Together, they work to improve joint mobility and flexibility. These supplements are available in a variety of forms, including capsules, tablets, and powders. They are generally safe for most people to take, but it is always recommended to speak with a healthcare professional before starting any new supplement regimen.

At a Glance: Our Top Picks

Joint Support Supplement with Glucosamine, Chondroitin, MSM, Turmeric and Boswellia - 90 Capsules Cover #TOP 1
Joint Support Supplement with Glucosamine, Chondroitin, MSM, Turmeric and Boswellia - 90 Capsules
ftb score rating icon 9.8
Nature Made Joint Support Supplement Cover #TOP 2
Nature Made Joint Support Supplement
ftb score rating icon 9.7
NUTRAHARMONY Glucosamine Chondroitin with Collagen - Joint Support Supplement Cover #TOP 3
NUTRAHARMONY Glucosamine Chondroitin with Collagen - Joint Support Supplement
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Top 10 Chondroitin & Glucosamine Combination Supplements

Joint Support Supplement with Glucosamine, Chondroitin, MSM, Turmeric and Boswellia - 90 Capsules

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Joint Support Supplement with Glucosamine, Chondroitin, MSM, Turmeric and Boswellia - 90 Capsules Cover
Glucosamine Chondroitin MSM – Joint Support Supplement for Women and Men with Glucosamine Sulfate 1500 mg, Chondroitin and MSM – for Cartilage, Joint Health and Flexibility – 90 Capsules

Support your healthy joint function, reduce joint discomfort, and maintain cartilage health with this joint support supplement. The expert formula includes Glucosamine, Chondroitin, MSM, Turmeric, and Boswellia, which work together to provide a solid foundation for joint health and function. The supplement also supports an active lifestyle by increasing joint mobility and reducing discomfort. The capsules are made with globally-sourced, non-GMO, gluten-free, dairy-free, sugar-free, and soy-free ingredients, and come in a convenient flip-top bottle for on-the-go nutrition.

What We Like
Improves joint stiffness
Reduces knee discomfort
Long-term relief noted
Supports active lifestyle
Helps with hand stiffness

Nature Made Joint Support Supplement

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Nature Made Joint Support Supplement Cover
Nature Made Glucosamine Chondroitin Complex with MSM, Dietary Supplement for Joint Support, 120 Caplets, 60 Day Supply

The Nature Made Glucosamine Chondroitin Complex with MSM is a dietary supplement designed to support your joint cartilage, allowing your joints to move smoothly. Each bottle contains 120 caplets, giving you a 60-day supply. To ensure the product's quality, customers must be present during delivery to avoid any damage caused by sunlight or heat. The supplement is gluten-free, contains no synthetic dyes, or artificial flavors. Adults should take two of these caplets daily with water and a meal.

What We Like
Effective for joint pain relief
Good value for the price
Noticeable results in a week
Easy to combine with other supplements
#TOP 3

NUTRAHARMONY Glucosamine Chondroitin with Collagen - Joint Support Supplement

SB-122
NUTRAHARMONY Glucosamine Chondroitin with Collagen - Joint Support Supplement Cover
Glucosamine Chondroitin MSM Collagen | HSA | Joint Support Supplement 2800 mg | Made in USA | FSA Approved Product Items | Flexibility Nutritional Vitamins | For Men & Women, 120 Capsules

NUTRAHARMONY Joint Support Supplement is a dietary supplement that promotes joint health and flexibility. It contains glucosamine, chondroitin, MSM, and collagen, which are essential components for maintaining the health of cartilage, ligaments, tendons, and skin. Glucosamine helps with the formation of cartilage and is necessary for recovery and maintenance of working capacity. Chondroitin promotes the formation of calcium in bones and cartilage tissue, which is recommended for athletes with injuries and the elderly to develop joints, the motor function of joints, and strengthen ligaments, cartilage, tendons, and even skin. MSM is the richest source of sulfur, which is an antioxidant and essential for strengthening connective tissues. Collagen is necessary for strengthening the skin and connective tissues. This joint supplement is sugar, soy, and GMO-free and manufactured in the USA with advanced technology to ensure the finest quality and purity.

What We Like
Joint health support
Essential components for cartilage, ligaments, and skin
Manufactured in the USA
#TOP 4

Doctor's Best Glucosamine Chondroitin Msm Capsules

DRB-00081
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Doctor's Best Glucosamine Chondroitin Msm with OptiMSM Capsules, Supports Healthy Joint Structure, Function & Comfort, Non-GMO, Gluten Free, Soy Free, 240 Count (Pack of 1)

Doctor's Best Joint Support is a dietary supplement that combines glucosamine, chondroitin, and MSM to support healthy joint structure, function, and comfort. Glucosamine helps prevent joint tissue breakdown and associated symptoms such as pain, stiffness, and weakness. Chondroitin absorbs fluid in the bones to keep joints healthy. MSM provides dietary sulfur, which strengthens joint tissues and helps with elasticity. This powerful combination of proven, purified ingredients can improve joint flexibility and protect joint tissue. Doctor's Best Joint Support can also support overall health for hair, skin, and nails.

What We Like
Effective for joint pain relief
Quick results for knee discomfort
Easy to swallow capsules
Affordable pricing
Positive effects for pets
#TOP 5

Osteo Bi-Flex Triple Strength Joint Supplements

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Osteo Bi-Flex Triple Strength Joint Supplements Cover
Osteo Bi-Flex Glucosamine Triple Strength Plus Turmeric Supplement with Curcumin for Joint Support and Range of Motion, 40 Day Supply, 80 Coated Tablets, Joint Health Nutritional Supplements

Osteo Bi-Flex Triple Strength Joint Supplements is a joint health supplement that comes in a bottle of 80 coated tablets, containing glucosamine chondroitin to strengthen joints and Turmeric which has antioxidant benefits. It is the number 1 pharmacist-recommended joint care supplement brand and includes Joint Shield 5-LOXIN Advanced, a clinically studied herbal extract that has been shown to improve joint comfort in 7 days.

What We Like
Improves joint comfort in 7 days
Number 1 pharmacist-recommended joint care supplement brand
Turmeric included for antioxidant benefits
Contains glucosamine chondroitin to nourish and strengthen joints for long-term
#TOP 6

Move Free Advanced Glucosamine Chondroitin MSM Joint Support Supplement - 120 Tablets

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Move Free Advanced Glucosamine Chondroitin MSM Joint Support Supplement - 120 Tablets Cover
Move Free Advanced Glucosamine Chondroitin MSM Joint Support Supplement, Supports Mobility Comfort Strength Flexibility & Bone - 120 Tablets (40 servings)*

Move Free Advanced Glucosamine Chondroitin MSM Joint Support Supplement is a joint health supplement that combines heritage joint support ingredients with clinically studied mineral complex Uniflex to support joint comfort in as little as 14 days. It helps support the 5 signs of joint health: joint mobility, comfort, strength, flexibility, and lubrication. The exclusive state-of-the-art technology allows the same amount of powerful ingredients to be packed into a smaller tablet, making it easier to swallow. Adults can take three tablets once a day with a meal or one tablet three times daily with meals.

What We Like
Supports joint comfort in as little as 14 days with clinically studied mineral complex Uniflex
Helps support the 5 signs of joint health: joint mobility, comfort, strength, flexibility, and lubrication
Exclusive state-of-the-art technology allows the same amount of ingredients to be packed into a smaller tablet, making it easier to swallow
#TOP 7

Nature's Bounty Joint Health Supplement, 110 Capsules

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Nature's Bounty Joint Health Supplement, 110 Capsules Cover
Nature's Bounty Glucosamine Chondroitin Pills and Dietary Supplement, Support Joint Health, 110 Capsules

Support your joint health with Nature's Bounty Glucosamine Chondroitin Pills and Dietary Supplement. This supplement nourishes your joints and helps maintain healthy cartilage. It contains Vitamin C and Manganese, which work together to support the structural framework of your joints. Plus, it is Non-GMO so you can feel good about what you're putting in your body. Choose this Chondroitin Supplement to keep your joints healthy and strong.

What We Like
Effective for joint health
Good price for quality
Easy to take
Quick delivery
#TOP 8

Nutricost Glucosamine 1800mg with Chondroitin & MSM

NTC-31040
Nutricost Glucosamine 1800mg with Chondroitin & MSM Cover
Nutricost Glucosamine 1800mg with Chondroitin & MSM, 240 Tablets, 120 Servings - Non-GMO, Gluten Free

Nutricost Glucosamine Joint Support Formula is a powerful supplement designed to promote healthy joints. With each serving, you get 1,800mg of Glucosamine HCl, which is known to support joint health. Additionally, this formula includes 90mg of Chondroitin and 425mg of MSM, both of which have been shown to provide joint support. This supplement comes in a bottle of 240 tablets, providing 120 servings, which is enough for a 4-month supply if taken as recommended. The tablets are soy-free, non-GMO, and gluten-free, making them suitable for a wide range of dietary needs. Nutricost Glucosamine Joint Support Formula is made in a GMP compliant, FDA registered facility, ensuring its quality and safety.

What We Like
Powerful joint support
High dosage of Glucosamine HCl
Includes Chondroitin and MSM
#TOP 9

Move Free Advanced Joint Support Supplement - 120 Tablets

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Move Free Advanced Joint Support Supplement - 120 Tablets Cover
Move Free Advanced Glucosamine Chondroitin MSM + Vitamin D3 Joint Support Supplement, Supports Mobility Comfort Strength Flexibility & Bone + Immune Health - 120 Tablets (60 servings)*

Move Free Advanced Joint Support Supplement is specially designed for men and women to support joint health, mobility, comfort, flexibility, bone, muscle, and immune health. It contains clinically tested mineral complex UNIFLEX to support joint comfort within 2 weeks, MSM for extra cartilage support, and Vitamin D3 for strong bone support. The recommended dosage is two tablets once a day with a meal or one tablet twice a day, making it easy to incorporate into your daily routine.

What We Like
Contains clinically tested ingredients to support joint comfort and extra cartilage support
Provides strong bone support with Vitamin D3 to maintain healthy levels of Calcium and Magnesium
Supports joint, bone, muscle, and immune health for optimal mobility and flexibility
#TOP 10

Clean Nutraceuticals Joint Support Supplement

Glucosamine Chondroitin MSM
Natural
Clean Nutraceuticals Joint Support Supplement Cover
Clean Nutraceuticals Glucosamine Chondroitin MSM 1500mg with Turmeric Curcumin, Collagen, Hyaluronic Acid, Omega 3 – Joint Health Supplement for Men & Women – Joint Complex – 120 Count

Clean Nutraceuticals Joint Support is an all-in-one supplement designed to enhance your joint health. It combines Glucosamine Sulfate for cartilage repair, Chondroitin Sulfate for improved flexibility, and MSM for effective pain relief. Additionally, it features powerful antioxidant ingredients like Turmeric, Ginger, and Boswellia, which can help reduce inflammation and discomfort in your joints. This supplement is particularly beneficial for those experiencing age-related joint issues. You may start feeling relief quickly, but for optimal long-term results, consistency is key.

What We Like
Comprehensive joint health support
Reduces inflammation and pain
Improves joint flexibility
Contains essential vitamins
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Frequently Asked Questions (FAQs)

1. Should you take glucosamine and chondroitin together?

Taking glucosamine and chondroitin together may provide some pain relief for osteoarthritis. Glucosamine alone may not be as effective for pain relief unless combined with chondroitin.

2. Who should not take glucosamine & chondroitin?

Glucosamine and chondroitin supplements are not recommended for children, pregnant or nursing women, and women who could become pregnant. This is due to the limited knowledge of their effects on a developing child or baby.

3. What supplements should not be taken with glucosamine chondroitin?

If you are taking the anticoagulant warfarin (Jantoven), it is important to be cautious when using glucosamine and chondroitin. These supplements have the potential to increase the effects of warfarin, increasing the risk of bleeding.

4. Which is better for joints turmeric or glucosamine chondroitin?

Both turmeric and glucosamine chondroitin have their own benefits for joint health. Glucosamine chondroitin is more specifically focused on improving joint health, while turmeric is a more multi-purpose superfood. Both are generally safe for daily supplementation and can improve joint health and flexibility in their own ways.

5. What are the negative side effects of glucosamine chondroitin?

Some possible negative side effects of glucosamine chondroitin supplements include nausea, diarrhea, constipation, stomach pain, gas, bloating, hair loss, and puffy eyelids.

6. Is glucosamine and chondroitin hard on your kidneys?

Taking glucosamine for an extended period of time may lead to acute interstitial nephritis and renal toxicity in some cases. Patients with a history of glucosamine-related products have shown signs of renal failure and high levels of renal and hepatic toxicity.

7. Is Glucosamine Chondroitin hard on your liver?

Clinical trials have not linked glucosamine and chondroitin to liver injury or serum enzyme elevations. Reported cases of clinically apparent liver injury from these supplements are rare and have not been reported in prospective trials.

Editor's Notes

During our chondroitin & glucosamine combination supplement research, we found 24 chondroitin & glucosamine combination supplement products and shortlisted 10 quality products. We collected and analyzed 492,624 customer reviews through our big data system to write the chondroitin & glucosamine combination supplements list. We found that most customers choose chondroitin & glucosamine combination supplements with an average price of $21.63.

The chondroitin & glucosamine combination supplements are available for purchase. We have researched hundreds of brands and picked the top brands of chondroitin & glucosamine combination supplements, including Vimerson Health, Nature Made, NUTRAHARMONY, Doctor's BEST, Osteo Bi-Flex. The seller of top 1 product has received honest feedback from 2,404 consumers with an average rating of 4.9.

Written by
Elisa Drew Avatar

Elisa Drew is a really professional copywriter specializing in baby products with five years of experience working as a pediatrician once. She has published a series of baby books purchased by over thirty thousand people in the United States.