Best OTC Medicinal Sleep Aids of 2025

Bonnie Salem Avatar
Bonnie Salem
Last Updated: Jan 16, 2025

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OTC medicinal sleep aids are non-prescription medications designed to help individuals fall asleep and stay asleep. These products contain various active ingredients such as diphenhydramine, doxylamine succinate, and melatonin, which work to promote relaxation and drowsiness. Some popular OTC medicinal sleep aids include Tylenol PM, Advil PM, and ZzzQuil. While these products may be effective for short-term use, individuals should consult with a healthcare professional before taking any sleep aids on a regular basis. It is also important to follow the recommended dosage and avoid combining these products with alcohol or other medications that may cause drowsiness.

At a Glance: Our Top Picks

HealthA2Z Sleep Aid, 250 Softgels Cover #TOP 1
HealthA2Z Sleep Aid, 250 Softgels
ftb score rating icon 9.8
Amazon Basic Care Sleep Aid Tablets, 96 Count Cover #TOP 2
Amazon Basic Care Sleep Aid Tablets, 96 Count
ftb score rating icon 9.7
Tylenol Simply Sleep Nighttime Aid Cover #TOP 3
Tylenol Simply Sleep Nighttime Aid
ftb score rating icon 9.5

Top 10 OTC Medicinal Sleep Aids

#TOP 1

HealthA2Z Sleep Aid, 250 Softgels

FPA028
Blue
HealthA2Z Sleep Aid, 250 Softgels Cover
HealthA2Z Sleep Aid, Diphenhydramine Softgels, 50mg, Supports Deeper, Restful Sleeping, Non Habit-Forming (250 Counts)

HealthA2Z Sleep Aid is a non-habit forming OTC medicinal sleep aid that helps you fall asleep fast and stay asleep. The softgels are easy to swallow and can be used for occasional sleeplessness. The recommended dosage for adults and children over 12 years is one softgel at bedtime or as directed by a doctor. The active ingredient is Diphenhydramine HCl 50mg, which is comparable to UNISOM.

What We Like
Effective sleep aid
Gentle drowsiness
Easy to swallow
No morning grogginess
Affordable alternative
What We Don't Like
Slow to take effect
Might cause tingling sensation
#TOP 2

Amazon Basic Care Sleep Aid Tablets, 96 Count

Amazon Basic Care
441B8
White
Amazon Basic Care Sleep Aid Tablets, 96 Count Cover
Amazon Basic Care Nighttime Sleep Aid Tablets for Adults, Doxylamine Succinate 25 mg, 96 Count

The Amazon Basic Care Sleep Aid Tablets contain doxylamine succinate 25 mg, which helps reduce difficulty in falling asleep. It is clinically tested and proven effective for adults and children ages 12 years and older. This nighttime sleep aid is gluten-free and contains no pain reliever. With just one tablet per dose, it helps you fall asleep and focus on sleep.

What We Like
Effective for restful sleep
No morning drowsiness
Easy to incorporate into routine
Non-prescription option
Helps with nasal congestion
What We Don't Like
Can be very potent
May require full 8 hours of sleep
#TOP 3

Tylenol Simply Sleep Nighttime Aid

308431000
Blue
Tylenol Simply Sleep Nighttime Aid Cover
Tylenol Simply Sleep Nighttime Sleep Aid Caplets with 25 mg of Diphenhydramine HCl, Non-Habit Forming Sleep Aid for Adults, 100 ct

Tylenol Simply Sleep is a nighttime sleep aid designed to help you overcome occasional sleeplessness. Each caplet contains 25 mg of diphenhydramine hydrochloride, which assists in easing you into sleep, so you wake up feeling rejuvenated. This product is suitable for adults and children aged 12 and older, making it versatile for family use. Unlike other sleep aids, Simply Sleep is non-habit forming when used as directed, allowing you to enjoy restful nights without worry. Simply take two caplets at bedtime for a quick journey into sleep, ensuring you get the rest you need.

What We Like
Effective for resuming sleep
Non-addictive formula
Quick onset of drowsiness
No morning grogginess
Convenient for travel
What We Don't Like
May lose effectiveness over time
Sensitive users may experience side effects
#TOP 4

RXZELL Sleep Aid

RZDIPHEN50
RXZELL Sleep Aid Cover
RXZELL Sleep Aid, Diphenhydramine 50mg, Easy-to-Swallow Softgels, Supports Deeper Restful Sleeping, Non Habit-Forming (220 Counts)

RXZELL Sleep Aid is a nighttime sleep aid that helps you reach deeper, restful sleep at night. With its easy-to-swallow maximum strength softgels, it delivers maximum performance. Simply take one softgel before bed, and relax your mind and body effortlessly with its active ingredient, Diphenhydramine HCl. This sleep aid is safe, non habit-forming, and suitable for adults and children over 12 years. Comparable to Unisom SleepGels, RXZELL Sleep Aid is the perfect solution for those looking to fall asleep faster and enjoy a deeper, more restful sleep.

What We Like
Effective for restful sleep
Fast-acting results
Easy to swallow softgels
No grogginess the next day
Generous supply of softgels
What We Don't Like
Occasional grogginess reported
Variable effectiveness for some users
#TOP 5

Unisom SleepTabs, Nighttime Sleep-aid, 80 Tablets

094-01-0934
No Artificial Color
Unisom SleepTabs, Nighttime Sleep-aid, 80 Tablets Cover
Unisom SleepTabs, Nighttime Sleep-aid, Doxylamine Succinate, 80 Tablets

Unisom SleepTabs Nighttime Sleep-aid is a safe and effective way to fall asleep faster and stay asleep through the night. It is non-habit forming and does not cause grogginess or lingering side effects. Unisom is a trusted brand recommended by pharmacists. Millions of people rely on Unisom for a restful night's sleep.

What We Like
Effective for falling asleep
Helps stay asleep longer
No bitter taste
Small and easy to swallow
Works well for pregnancy symptoms
What We Don't Like
May cause morning drowsiness
Delayed onset for some users
#TOP 6

ZzzQuil ULTRA Sleep Aid Liquid, 48 Count

ZzzQuil ULTRA Sleep Aid Liquid, 48 Count Cover
ZzzQuil ULTRA, Sleep Aid, Nighttime Sleep Aid, 25 mg Doxylamine Succinate, From Makers of Nyquil, Non- Habit Forming, Fall Asleep Fast, Stay Asleep Longer, 48 Count

ZzzQuil ULTRA is a liquid sleep aid with 25 mg Doxylamine Succinate, clinically proven to help you stay asleep up to 27% longer. It helps you fall asleep fast and get less interrupted sleep through the night. With doxylamine succinate, a non-habit forming ingredient, it's safe and effective for a better, more restful sleep. From the makers of Vicks NyQuil, ZzzQuil ULTRA is the world's #1 sleep aid brand that helps more people get great sleep.

What We Like
Promotes restful sleep
No morning grogginess
Effective for jetlag
Quick sleep onset
Good for travel
What We Don't Like
Packaging difficult to open
Variable effectiveness for some
#TOP 7

ZzzQuil Nighttime Sleep Aid Liquid Twin Pack

3.239E+11
Cranberry
ZzzQuil Nighttime Sleep Aid Liquid Twin Pack Cover
ZzzQuil, Sleep Aid, Nighttime Sleep Aid Liquid, 50 mg Diphenhydramine HCl, Fall Asleep Fast, Non-Habit Forming, Warming Berry Flavor, 12 FL OZ (Pack of 2)

ZzzQuil Nighttime Sleep Aid Liquid is the world's #1 sleep aid brand developed by sleep experts at Vicks. The liquid helps you fall asleep in as little as 20 minutes, and it is non-habit forming with clinically proven ingredients. Wake up refreshed tomorrow with the sound sleep the liquid provides. The delicious Warming Berry flavor tastes great, and it is perfect for home use or travel.

What We Like
Induces relaxing sleep
Non-addictive formula
Helps fall asleep quickly
No grogginess in the morning
Tasty flavor options
What We Don't Like
Some flavors not appealing
#TOP 8

Kirkland Sleep Aid 25 mg

719940
Kirkland Sleep Aid 25 mg Cover
Kirkland Sleep Aid Doxylamine Succinate 25 mg 192 Tablets

Kirkland Sleep Aid offers a powerful solution for those seeking restful sleep. With 25 mg of Doxylamine Succinate, this over-the-counter medication helps you fall asleep more easily, making those sleepless nights a thing of the past. Unlike some sleep aids, it is non-habit forming, allowing you to use it without worrying about dependency. Additionally, it is comparable to Unisom Sleeptabs, giving you a trusted option for sleep support. This product is convenient for anyone looking to improve their sleep quality with a reliable and effective formula.

What We Like
Effective sleep aid
Good value for price
Fast-acting results
Reduces grogginess
Long-term user satisfaction
What We Don't Like
Unpleasant taste
Initial adjustment period
#TOP 9

A+Health Diphenhydramine Sleep Aid 160 Count

SLEEP AID
Blue
A+Health Diphenhydramine Sleep Aid 160 Count Cover
A+Health Nighttime Sleep Aid Diphenhydramine 50 mg Softgels Maximum Strength, 160 Count

A+Health Sleep Aid offers a convenient solution for those occasional sleepless nights. Each softgel contains 50mg of diphenhydramine, a non-habit forming ingredient that helps you feel drowsy by blocking histamines that keep you awake. These maximum strength softgels are easy to swallow, ensuring you can quickly get the rest you need. With 160 capsules in a bottle, you'll have plenty on hand for when sleep eludes you. Experience fast-acting relief and enjoy deeper sleep with this effective nighttime aid.

What We Like
High quality
Fast acting
Effective sleep aid
Good price
Quick delivery
What We Don't Like
Pills stick together
Capsules may tear easily
#TOP 10

ZzzQuil Nighttime Sleep Aid LiquiCaps

308492
ZzzQuil Nighttime Sleep Aid LiquiCaps Cover
ZzzQuil, Nighttime Sleep Aid LiquiCaps, 25 mg Diphenhydramine HCl, No.1 Sleep-Aid Brand, Non-Habit Forming, Fall Asleep Fast, 72 Count

ZzzQuil Nighttime Sleep Aid LiquiCaps is a non-habit forming sleep aid developed by trusted sleep experts at Vicks. The LiquiCaps help users fall asleep fast and sleep soundly, ensuring they wake up refreshed the next day. Each dose contains 50mg of Diphenhydramine HCI and is designed to help users achieve a great night's sleep.

What We Like
Non-habit forming
Fast-acting
Gentle on waking
Easy to take
Good value for price
What We Don't Like
May not be as strong as prescription
Pills occasionally stuck together
Buying Guide Image

Frequently Asked Questions (FAQs)

1. What is the best across the counter sleep aid?

In general, diphenhydramine is less expensive than doxylamine. Since its use is associated with less of a hangover effect, and is milder than doxylamine, it is usually a good first choice in this category of and OTC sleep aid.

2. Is there an over-the-counter sleeping pill?

Any adult can buy OTC sleep medications at a store. OTC sleep aids often contain an antihistamine. This drug treats allergies, but it can also make you drowsy. Some people take melatonin or valerian supplements to help them sleep.

Editor's Notes

During our otc medicinal sleep aid research, we found 24 otc medicinal sleep aid products and shortlisted 10 quality products. We collected and analyzed 430,588 customer reviews through our big data system to write the otc medicinal sleep aids list. We found that most customers choose otc medicinal sleep aids with an average price of $10.85.

The otc medicinal sleep aids are available for purchase. We have researched hundreds of brands and picked the top brands of otc medicinal sleep aids, including HealthA2Z, Tylenol, RXZELL, Unisom, ZzzQuil. The seller of top 1 product has received honest feedback from 10,591 consumers with an average rating of 4.9.

Written by
Bonnie Salem Avatar

Bonnie Salem is a stay-at-home mother with two-year-old twins and has spent almost half of her life surrounded by baby products. As a mother and a professional copywriter, she has an insightful and unique eye for researching products suitable for infants. Bonnie Salem is an expert in health and nutrition who lives with her family in New Jersey. She has over 15 years of working experience in an institute of medicine after graduating from the University of Toronto. She is highly interested in personal health and wellness.

OTC Medicinal Sleep Aids Comparison Table

#TOP1
#TOP2
#TOP3
#TOP4
#TOP5
#TOP6
#TOP7
#TOP8
#TOP9
#TOP10
Brand HealthA2Z Amazon Basic Care Tylenol RXZELL Unisom ZzzQuil ZzzQuil KIRKLAND A+Health ZzzQuil
Item dimensions L x W x H 2.9 x 2.9 x 5.4 inches 1.63 x 3.25 x 1.69 inches 20 x 40 x 20 inches 2.25 x 2.25 x 4.5 inches 1.75 x 3.06 x 3.13 inches 3.94 x 0.95 x 3.07 inches 5.25 x 2.63 x 6.88 inches 6 x 8 x 2 inches 2 x 2 x 4.25 inches 5.24 x 1.5 x 3.74 inches
Product Benefits Sleep Aids Sleep Aid Sleeplessness Relief Restful Sleep,Sleep Aid Sleeplessness Relief - Sleep Support Sleep Support Sleeplessness Relief Sleep Support
Item Weight - 0.07 Pounds 0.02 Pounds 0.37 Pounds 1.24 Ounces - 0.78 Pounds 1.6 ounces 0.23 Pounds 0.03 Pounds
Unit Count - - - 220 Count - 48 Count 24 Fluid Ounces 192.0 Count 160 Count 72 Count
Item Form - - - Softgel - Tablet Liquid Tablet gel, capsule, Capsule Softgel Capsule
Flavor - - - Unflavored - - Warming Berry Unflavored Unflavored Unflavored
Age Range (Description) - - - Adult, Kid - Adult Adults & children 12 yrs & over - Adult Adult,Kid
FTB Score
ftb score rating icon 9.8
ftb score rating icon 9.7
ftb score rating icon 9.5
ftb score rating icon 9.5
ftb score rating icon 9.5
ftb score rating icon 9.3
ftb score rating icon 9.1
ftb score rating icon 8.9
ftb score rating icon 8.8
ftb score rating icon 8.6
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