Best Calcium L-Lysine Supplements of 2026

Elisa Drew Avatar
Elisa Drew
Last Updated: Jan 13, 2026

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Calcium L-Lysine supplements are a popular choice for those looking to increase their calcium intake. These supplements are formulated with L-Lysine, an essential amino acid that helps the body absorb and utilize calcium more efficiently. Calcium L-Lysine supplements are often recommended for individuals who are at risk of developing osteoporosis, a condition that causes the bones to become weak and brittle. These supplements may also help support healthy teeth and gums, as well as promote overall bone health. They come in various forms, including capsules, tablets, and chewable tablets, making them easy to incorporate into any daily routine.

At a Glance: Our Top Picks

THORNE Lysine 500mg Capsules Cover #TOP 1
THORNE Lysine 500mg Capsules
ftb score rating icon 9.9
NOW L-Lysine Amino Acid 500mg, 250 Tablets Cover #TOP 2
NOW L-Lysine Amino Acid 500mg, 250 Tablets
ftb score rating icon 9.8
Life Extension L-Lysine 620mg - Essential Amino Acid for Active Lifestyle Cover #TOP 3
Life Extension L-Lysine 620mg - Essential Amino Acid for Active Lifestyle
ftb score rating icon 9.6

Top 3 Calcium L-Lysine Supplements

#TOP 1

THORNE Lysine 500mg Capsules

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THORNE Lysine 500mg Capsules Cover
THORNE - Lysine - Essential Amino Acid for Skin Health, Energy Production & Immune Function* - 500 mg - 60 Servings

THORNE Lysine Capsules are packed with benefits for you. Firstly, they aid in wound healing by boosting collagen production in your skin. Secondly, they support your immune system, helping it stay strong and keeping your gum and lip tissues healthy. Thirdly, these capsules promote skin elasticity and calcium absorption for robust bones and teeth. Lastly, they are free from common allergens, making them suitable for many users.

What We Like
Easy to swallow capsules
Supports immune system
Effective for cold sores
Consistent quality formulation
Noticeable health benefits

NOW L-Lysine Amino Acid 500mg, 250 Tablets

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NOW L-Lysine Amino Acid 500mg, 250 Tablets Cover
NOW Supplements, L-Lysine (L-Lysine Hydrochloride) 500 mg, Amino Acid, 250 Tablets

Get your essential amino acid L-Lysine from NOW Supplements, which cannot be produced by your body and must be obtained through your diet or supplementation. It supports the production of protein, hormones, enzymes, antibodies, and carnitine, as well as collagen which forms connective tissue such as skin, tendon, and bone. In addition, L-Lysine plays a crucial role in calcium absorption. This product is non-GMO, dairy-free, egg-free, gluten-free, nut-free, soy-free, vegan/vegetarian, and has been quality assured by GMP. It is packaged in the USA by a family owned and operated company since 1968.

What We Like
Cold sore prevention
Faster healing for mouth sores
Helps chapped and cracked lips
Easy-to-swallow 500mg size
No side effects noticed

Life Extension L-Lysine 620mg - Essential Amino Acid for Active Lifestyle

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Life Extension L-Lysine 620mg - Essential Amino Acid for Active Lifestyle Cover
Life Extension L-Lysine, 620 mg, Essential Amino Acid for Healthy nitrogen Balance, Calcium Metabolism, Stress Response & More, Gluten-Free, Non-GMO, Vegetarian, 100 Capsules

The Life Extension L-Lysine supplement is a great option for athletes and those following plant-based diets who may need to supplement with lysine. This essential amino acid helps inhibit glycation, encourages a healthy stress response, and maintains lean body mass and healthy store of nitrogen. The product is gluten-free, non-GMO, and sourced using only the finest raw ingredients with the purity and potency your body deserves. It is manufactured in the USA, based on the latest scientific findings with the exact ingredients and dosages used in the studies that inspired them, ensuring maximum bioavailability and efficacy is achieved.

What We Like
Essential amino acid for building blocks of protein
Encourages healthy stress response and nitrogen balance
Inhibits glycation for graceful aging
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Frequently Asked Questions (FAQs)

1. What should I not take with L Lysine?

If you are currently being treated with any of the following medications or supplements, you should not use lysine supplements without first talking to your health care provider. Arginine -- Arginine and lysine share common pathways in the body. Therefore, excess arginine may lower lysine levels in the body.

2. What is the supplement L Lysine good for?

Lysine is a building block for making proteins in the body. It might also prevent the herpes virus from growing. People use lysine for cold sores, canker sores, athletic performance, diabetes, and many other conditions, but there is no good scientific evidence to support most of these uses.

3. What happens if you take lysine everyday?

Taking lysine supplements is very safe and does not seem to cause many side effects. Most people can take a daily dose of up to 3 grams (g) of lysine without any side effects. Increasing the dosage of lysine to 10–15 g a day may result in digestive issues, such as: diarrhea.

4. Which is better lysine or L Lysine?

Lysine is an α-amino acid, which consists of two enantiomers known as L-lysine and D-lysine. L-lysine has the S configuration at the α-carbon. Also, it is the biologically active form of lysine. Therefore, the main difference between lysine and L lysine is their structure and importance.

Editor's Notes

During our calcium l-lysine supplement research, we found 24 calcium l-lysine supplement products and shortlisted 3 quality products. We collected and analyzed 104,666 customer reviews through our big data system to write the calcium l-lysine supplements list. We found that most customers choose calcium l-lysine supplements with an average price of $14.03.

The calcium l-lysine supplements are available for purchase. We have researched hundreds of brands and picked the top brands of calcium l-lysine supplements, including THORNE, NOW Foods, Life Extension. The seller of top 1 product has received honest feedback from 48,091 consumers with an average rating of 4.9.

Written by
Elisa Drew Avatar

Elisa Drew is a really professional copywriter specializing in baby products with five years of experience working as a pediatrician once. She has published a series of baby books purchased by over thirty thousand people in the United States.