Best Hypoallergenic Hand Creams of 2025

Gold Bond Ultimate Healing Hand Cream is a 3-oz. tube of nourishing moisture that contains 7 intensive moisturizers, plus vitamins A, C and E. It repairs dry, problem hands, even after washing your hands, and is hypoallergenic and fragrance free. Customers love it for its quick absorption and effectiveness, even for those with sensitive skin.

The Salcoll Collagen Hand Cream is a hypoallergenic, all-natural moisturizing lotion that helps repair dry, chapped, and wrinkled skin. It contains 100% natural marine collagen that penetrates deep into the skin, supplying essential proteins and elastins to repair damaged tissues. This hand cream soothes burns, scrapes, and chapped skin and stimulates the healing process to help your hands recover quickly. It is perfect for all skin types, including sensitive skin, and leaves your hands feeling touchably soft.

Cetaphil Healing Ointment is designed to provide relief for extremely dry, chapped, and irritated skin. This ointment features a high level of skin protectant petrolatum, which helps shield and repair dry areas quickly. With the addition of shea butter, the formula softens and smooths your skin, while vitamin E enhances its resilience. You can enjoy intense hydration for up to 48 hours, helping maintain your skin's natural barrier. Plus, its hypoallergenic and fragrance-free formula ensures it's gentle on sensitive skin, making it a reliable choice for everyday use.

The Dove Dermaseries Hand Cream is the best moisturizing solution for very dry hands. With its hypoallergenic and fragrance-free formula, this hand cream provides a caring touch for unhappy, dry hands. It is clinically proven to be an effective moisturizer for dry skin protection. The fast-absorbing and non-sticky formula ensures that it is convenient to use on a daily basis. Tested with dermatologists, this Dove hand cream is a reliable option for those with dry hands, providing the necessary hydration and nourishment for healthier skin.

O'Keeffe's Hand Cream is designed to provide intense relief for extremely dry and cracked hands. This highly concentrated formula creates a protective barrier on your skin, locking in moisture to keep your hands hydrated throughout the day. When used regularly, you'll notice a significant improvement in your skin's texture and softness in just a few days. For optimal results, apply the cream after washing your hands, bathing, or before bedtime. It is also suitable for sensitive skin, making it a great choice for everyone, including those with diabetes.

O'Keeffe's Working Hands Hand Cream is a concentrated cream that creates a protective layer on the skin's surface and locks in moisture, providing guaranteed relief for extremely dry, cracked hands. For best results, apply after hand washing, bathing, and at bedtime. It is hypoallergenic, safe for people with diabetes, unscented, and non-greasy. The 3.4-ounce jar is an ideal size for travel.

Nécessaire Hand Cream offers a comprehensive solution for maintaining healthy hands. Formulated with five ceramides and peptides, this cream helps to heal and restore moisture, ensuring your skin feels soft and supple. The inclusion of niacinamide and marula oil enhances its effectiveness in treating dryness and brittle cuticles. Additionally, the cream is dermatologist-tested and hypoallergenic, making it suitable for sensitive skin. With a commitment to sustainability, the packaging is eco-friendly, so you can care for your hands while being kind to the planet.

O'Keeffe's Working Hands Hand Cream is a hardworking skincare that provides guaranteed relief for extremely dry, cracked hands. It creates a protective layer on the skin's surface that locks in moisture and keeps your skin hydrated. This extra strong hand cream is suitable for people with sensitive skin, including those with Diabetes. Apply after hand washing, after bathing, and at bedtime for the best results, and a small amount of product is needed.

Nécessaire Hand Retinol is an all-in-one serum specifically formulated for your hands. It visibly rejuvenates your skin, addressing issues like crepiness, wrinkles, and spots. With a blend of 0.25% pure retinol, 5% AHA, and 10 peptides, this serum works to improve the texture and appearance of your hands, making them look youthful and healthy. The dermatologist-tested formula is hypoallergenic and free from harmful additives, ensuring it’s gentle on your skin. For best results, apply it nightly to clean skin and follow with a hand cream.

Indulge in the luxurious Shea Better Vanilla Cashmere Hand Cream by eos. This hand cream provides 24-hour hydration for your hands, lasting through hand washing and leaving your hands feeling smooth. It is made with natural ingredients and 7 nourishing oils + butters, including natural shea butter and shea oil, for immediate and lasting moisture and protection. Apply this fast-absorbing, non-greasy, and deliciously scented hand cream to just-cleaned hands, paying special attention to dry, rough areas. eos hand cream is sustainable skin care that is paraben, phthalate, and gluten-free, as well as dermatologist tested, vegan, hypoallergenic, and Leaping Bunny certified.