Best Allergy Medicine of 2026

Bonnie Salem Avatar
Bonnie Salem
Last Updated: Jan 16, 2026

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Allergy medicine is a type of medication that is designed to relieve the symptoms of allergies. These symptoms can include sneezing, runny nose, itchy and watery eyes, and even hives or rashes. There are a variety of allergy medicines available on the market, including antihistamines, decongestants, and nasal sprays. Antihistamines work by blocking the effects of histamine, which is the chemical responsible for causing allergy symptoms. Decongestants work by reducing the swelling in the nasal passages, while nasal sprays can provide relief for both nasal and eye symptoms. It's important to speak with a doctor or pharmacist before taking any allergy medicine, as some may have side effects or interact with other medications.

At a Glance: Our Top Picks

Pataday Once Daily Relief Extra Strength Relief 2.5ml Cover #TOP 1
Pataday Once Daily Relief Extra Strength Relief 2.5ml
ftb score rating icon 9.9
Amazon Basic Care Allergy Relief Tablets, 10mg, 300 Count Cover #TOP 2
Amazon Basic Care Allergy Relief Tablets, 10mg, 300 Count
ftb score rating icon 9.8
Amazon Basic Care Allergy Nasal Spray Cover #TOP 3
Amazon Basic Care Allergy Nasal Spray
ftb score rating icon 9.6

Top 10 Allergy Medicine

Pataday Once Daily Relief Extra Strength Relief 2.5ml

0065081603
Clear
2 Count (Pack of 1)
Pataday Once Daily Relief Extra Strength Relief 2.5ml Cover
Alcon Pataday Once Daily Relief Extra Strength Relief, 2.5 mL (Pack of 2)

Pataday Once Daily Relief Extra Strength Relief 2.5ml is a fast and effective antihistamine that relieves itchy eyes in minutes. It is easy to use with just one drop needed once a day, and provides relief for up to 24 hours. It contains the #1 doctor-prescribed eye allergy itch relief ingredient and works by limiting the release of chemicals that cause inflammation.

What We Like
Doctor recommended relief
Effective for itchy eyes
Long-lasting single drop
Quick soothing action
High quality ingredients
What We Don't Like
Small bottle size
Higher price point
#TOP 2

Amazon Basic Care Allergy Relief Tablets, 10mg, 300 Count

Amazon Basic Care
Amazon Basic Care Allergy Relief Tablets, 10mg, 300 Count Cover
Amazon Basic Care 24 Hour Allergy Relief, Cetirizine Hydrochloride Tablets, 10 mg, 300 Count (Packaging may vary)

Amazon Basic Care Allergy Relief Tablets contain cetirizine hydrochloride, an antihistamine that provides 24-hour relief from common indoor and outdoor allergy symptoms, including runny nose, sneezing, itching, and watery eyes. These tablets are gluten-free and original prescription strength, approved for the treatment of both indoor and outdoor allergies. They are useful for those with sensitivities to harmless substances like flowers, trees, pets, and dust.

What We Like
Excellent value for money
Long-lasting all-day relief
Same effectiveness as name brand
Small, easy-to-swallow tablets
Large, convenient bottle size
What We Don't Like
May cause slight drowsiness

Amazon Basic Care Allergy Nasal Spray

Amazon Basic Care
Green
Amazon Basic Care Allergy Nasal Spray Cover
Amazon Basic Care 24-Hour Allergy Relief Nasal Spray, Fluticasone Propionate (Glucocorticoid), 50 mcg, Full Prescription Strength, Non-Drowsy, 0.62 fl oz (Pack of 1)

The Amazon Allergy Nasal Spray offers lasting relief from allergy symptoms for a full day. With its active ingredient, Fluticasone Propionate, you can effectively combat issues like nasal congestion, sneezing, and itchy eyes. This full prescription strength spray allows for convenient once-daily use, ensuring you stay comfortable without feeling drowsy. Whether it’s pollen from flowers or dust from your home, this spray helps manage both indoor and outdoor allergens, making your daily life easier and more enjoyable.

What We Like
Affordable price
Comparable to name brands
Effective allergy relief
No unpleasant scent
Larger quantity
What We Don't Like
Spray nozzle feels a bit cheap
Mist delivery can be uneven

Benadryl Ultratabs Allergy Relief Tablets, 100 ct

300450170149 1/9
Pink
Benadryl Ultratabs Allergy Relief Tablets, 100 ct Cover
Benadryl Ultratabs Allergy Medicine, 25 mg Diphenhydramine HCl Antihistamine Tablets For Cold & Allergy Relief of Symptoms Like Sneezing, Runny Nose, Itchy Eyes & Throat, Hay Fever, 100 Count Tablets

Benadryl Ultratabs Allergy Relief Tablets are a doctor-recommended solution for allergy and cold symptoms. With 25mg diphenhydramine HCl per tablet, it provides powerful relief for sneezing, runny nose, itchy throat, and watery eyes due to upper respiratory allergies or the common cold. This 100-count bottle is easy to swallow for adults and children aged six and up, making it a convenient solution for indoor and outdoor allergies.

What We Like
Effective allergy relief
Good value and price
Convenient bottle packaging
Versatile human and pet use
Reliable for runny nose
What We Don't Like
Possible drowsiness
#TOP 5

Amazon Basic Care Cetirizine Hydrochloride 10 mg Allergy Tablets

Amazon Basic Care
Amazon Basic Care Cetirizine Hydrochloride 10 mg Allergy Tablets Cover
Amazon Basic Care All Day Allergy, Cetirizine Hydrochloride Tablets, 10 mg, Antihistamine, 30 Count (Packaging may vary)

The Amazon Basic Care Allergy Relief tablets contain cetirizine hydrochloride, a trusted antihistamine that helps ease symptoms caused by both indoor and outdoor allergies. If you suffer from sneezing, runny nose, or itchy eyes due to pollen, dust, or pet dander, these tablets offer temporary relief to help you feel more comfortable throughout the day. Each dose provides up to 24 hours of allergy symptom control, so you don’t have to worry about frequent dosing. Plus, these original prescription-strength tablets are gluten-free, making them a safe choice for many users seeking allergy relief.

What We Like
Affordable price
Same active ingredient as name brand
Long-lasting all-day relief
Small, easy-to-swallow tablets
Large, convenient bottle size
What We Don't Like
May cause slight drowsiness
Not as strong for some users
#TOP 6

Amazon Basic Care Allergy Relief Diphenhydramine HCl 25 mg

Amazon Basic Care
Pink
400 Count
Amazon Basic Care Allergy Relief Diphenhydramine HCl 25 mg Cover
Amazon Basic Care Complete Allergy Relief, Diphenhydramine HCl 25 mg, Relieves Symptoms, Antihistamine Tablets, 400 Count

Amazon Basic Care Allergy Relief provides multi-symptom relief for hay fever and upper respiratory allergies. Each tablet contains 25 mg of diphenhydramine HCl, an antihistamine, which can alleviate symptoms such as runny nose, sneezing, itching of the nose or throat, and itchy, watery eyes. The powerful dose of allergy-fighting medicine relieves allergy symptoms for 4-6 hours. These mini-tabs are easy to swallow, making them ideal for travel. Nighttime allergy relief is also available to help you rest. Suitable for adults and children 6 years and older.

What We Like
Easy to swallow
Affordable price
Works like name brands
Effective for allergies
Usable for pets
What We Don't Like
May cause drowsiness
Not for daily sleep aid
#TOP 7

Zyrtec 24 Hour Allergy Relief Tablets Bundle

93 Count
Zyrtec 24 Hour Allergy Relief Tablets Bundle Cover
Zyrtec 24 Hour Allergy Relief Tablets, Indoor & Outdoor Allergy Medicine with 10 mg Cetirizine Hydrochloride Antihistamine, Value Bundle of one, 90 ct Bottle & Three, 1 ct Travel Packs

The Zyrtec Allergy Relief Tablets offer a convenient bundle with a 90-count bottle plus three single-dose travel packs, making it easy for you to manage allergies both at home and on the go. These tablets provide fast, 24-hour relief from common indoor and outdoor allergens like pollen, dust, and pet dander, starting to work within the first hour. They effectively reduce symptoms such as runny nose, sneezing, and itchy, watery eyes, helping you feel more comfortable throughout the day. Suitable for adults and children over six, this medication is designed for long-lasting relief from seasonal and year-round allergies.

What We Like
Good value
Bonus travel pack
Fast relief
Effective for allergies
Quick delivery
What We Don't Like
Price could be lower
#TOP 8

Flonase Allergy Relief Nasal Spray

60000000122889
1 Count (Pack of 1)
Flonase Allergy Relief Nasal Spray Cover
Flonase Allergy Relief Nasal Spray, 24 Hour Non Drowsy Allergy Medicine, Metered Nasal Spray - 72 Sprays - Fall and Seasonal Allergy Relief

Flonase Allergy Relief Nasal Spray is a 24-hour non-drowsy allergy medicine that provides all-in-one relief for seasonal, year-round, indoor, and outdoor allergies. The easy-to-use nasal spray delivers prescription-strength non-drowsy relief for runny nose, sneezing, itchy nose and watery, itchy eyes, as well as nasal congestion relief. Suitable for adults and children 12 years of age and older, simply spray one to two times daily in each nostril for all-day relief that lasts.

What We Like
Fast allergy relief
Effective for sinus congestion
Works when other meds fail
Helpful for chronic conditions
What We Don't Like
Occasional spray mechanism issues
May cause mild nosebleeds
#TOP 9

ValuMeds 24-Hour Allergy Medicine (300-Count)

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ValuMeds 24-Hour Allergy Medicine (300-Count) Cover
ValuMeds 24-Hour Allergy Medicine Antihistamine for Pollen, Hay Fever, Dry, Itchy Eyes, Allergies | Cetirizine HCl 10mg Caplets, Compare to Leading Brand (300 Count)

ValuMeds 24-Hour Allergy Medicine provides fast and reliable support for allergy symptoms such as dry, itchy, watery eyes, a scratchy nose and throat, and sneezing. Its non-drowsy formula is safe for kids and adults, and a single dose can provide 24-hour relief. This medication starts working within an hour of ingestion and can be taken for indoor and outdoor protection.

What We Like
Affordable alternative to name brands
Effective allergy relief
Fast-acting, long-lasting results
Easy-to-swallow pills
No drowsiness or stomach issues
What We Don't Like
Requires time to see full effect
#TOP 10

Claritin 24 Hour Allergy Medicine, 100 Count

B078BBYNLC
White
Claritin 24 Hour Allergy Medicine, 100 Count Cover
Claritin Allergy Medicine for Adults, 24-Hour Non-Drowsy Loratadine 10mg Pills, Antihistamine, 100 Tablets

Claritin 24 Hour Allergy Medicine provides a powerful, non-drowsy relief for indoor and outdoor allergies, including symptoms such as sneezing, runny nose, itchy/watery eyes, and itchy throat/nose. With 10mg of loratadine per tablet, it effectively blocks the effects of histamines from over 200 different allergens, including pets, pollen, dust, and mold. This #1 doctor recommended non-drowsy oral allergy brand does not require a prescription, making it easy to find relief.

What We Like
Non-drowsy allergy relief
All-day effectiveness
Gentle on stomach
Easy to administer to pets
Good value
What We Don't Like
Relief duration may vary
Buying Guide Image

Allergy Medicine Buying Guide: What You Need to Know

Introduction

Allergies can be a pesky and uncomfortable annoyance for many people. Luckily, there are a wide variety of allergy medications available to help alleviate symptoms. However, with so many options on the market, it can be overwhelming to choose the right one. In this article, we'll discuss some factors to consider when selecting allergy medicine to help you find the best option for your needs.

Types of Allergy Medications

Before we dive into the specifics of choosing allergy medicine, it's important to understand the different types of allergy medications available.

Antihistamines

One of the most common types of allergy medications are antihistamines. These drugs work by blocking the effects of histamine, a chemical that is released by your body in response to an allergen. This can help to reduce symptoms such as sneezing, itching, and runny nose.

Decongestants

Another common type of allergy medication is decongestants. These drugs help to relieve nasal congestion by narrowing the blood vessels in the nose. This can help to reduce swelling and make it easier to breathe.

Corticosteroids

Corticosteroids are another type of allergy medication that can be effective in reducing symptoms. These drugs work by reducing inflammation in the body, which can help to alleviate symptoms such as congestion and swelling.

Immunotherapy

For people with severe allergies or allergies that are not well-controlled by other medications, immunotherapy may be an option. This type of treatment involves gradually exposing the body to increasing amounts of an allergen in order to build up immunity to it.

Factors to Consider

Now that we've covered the different types of allergy medications available, let's discuss some factors to consider when choosing the right allergy medicine for you.

Type and Severity of Allergies

One of the most important factors to consider when choosing allergy medicine is the type and severity of your allergies. For example, if you have seasonal allergies, an over-the-counter antihistamine may be sufficient to alleviate your symptoms. However, if you have more severe allergies or allergies that are not well-controlled by other medications, you may need a prescription medication or immunotherapy.

Possible Side Effects

Another factor to consider when choosing allergy medicine is the potential side effects. Some allergy medications may cause drowsiness, dry mouth, or other side effects, so it's important to read the label carefully and discuss potential side effects with your doctor.

Age and Other Medical Conditions

It's also important to consider your age and any other medical conditions you may have when choosing allergy medicine. For example, some allergy medications may not be suitable for children or people with certain medical conditions. Your doctor can help you to determine the best option for your needs.

Cost

Finally, it's important to consider the cost of allergy medication when choosing the right option for you. Some allergy medications may be more expensive than others, so it's important to weigh the cost against the potential benefits.

Conclusion

In conclusion, there are many factors to consider when choosing allergy medicine. It's important to consider the type and severity of your allergies, the potential side effects, your age and other medical conditions, and the cost of the medication. By taking these factors into account, you can find the right allergy medicine to help alleviate your symptoms and improve your quality of life.

Frequently Asked Questions (FAQs)

1. What medicine helps allergies fast?

When it comes to fast relief from allergies, antihistamines are commonly used. These medications work by blocking histamine, the chemical responsible for causing allergy symptoms like sneezing, itching, and runny nose. Some examples of antihistamines include cetirizine (Zyrtec Allergy), fexofenadine (Allegra Allergy), and loratadine (Claritin, Alavert).

2. Is it better to take Zyrtec at night or in the morning?

Cetirizine, also known as Zyrtec, can be taken at any time of the day. It is generally non-sedating for most people, so they prefer taking it in the morning. However, some individuals may experience drowsiness as a side effect. If cetirizine makes you drowsy, it is best to take it in the evening.

3. How do I stop allergies ASAP?

To get quick relief from allergies, antihistamines are effective in alleviating symptoms like sneezing, itching, a stuffy or runny nose, and watery eyes. Examples of oral antihistamines include cetirizine (Zyrtec Allergy), fexofenadine (Allegra Allergy), and loratadine (Claritin, Alavert). Additionally, corticosteroid nasal sprays can help improve nasal symptoms.

4. How do you get rid of allergies ASAP?

There are several ways to alleviate allergies quickly. These include using antihistamines, nasal steroid sprays, decongestants, and prescription allergy medications. Vitamin C can also help. Other measures include using humidifiers and dehumidifiers, switching to HEPA filters for heating and cooling systems, and considering the use of air purifiers.

Editor's Notes

During our allergy medicine research, we found 27 allergy medicine products and shortlisted 10 quality products. We collected and analyzed 1,328,405 customer reviews through our big data system to write the allergy medicine list. We found that most customers choose allergy medicine with an average price of $13.56.

The allergy medicine are available for purchase. We have researched hundreds of brands and picked the top brands of allergy medicine, including Alcon, Benadryl, Zyrtec, Flonase, ValuMeds. The seller of top 1 product has received honest feedback from 186 consumers with an average rating of 4.5.

Written by
Bonnie Salem Avatar

Bonnie Salem is a stay-at-home mother with two-year-old twins and has spent almost half of her life surrounded by baby products. As a mother and a professional copywriter, she has an insightful and unique eye for researching products suitable for infants. Bonnie Salem is an expert in health and nutrition who lives with her family in New Jersey. She has over 15 years of working experience in an institute of medicine after graduating from the University of Toronto. She is highly interested in personal health and wellness.

Allergy Medicine Comparison Table

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#TOP5
#TOP6
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#TOP8
#TOP9
#TOP10
Brand Alcon Amazon Basic Care Amazon Basic Care Benadryl Amazon Basic Care Amazon Basic Care Zyrtec Flonase ValuMeds Claritin
Product Benefits Eye Care Allergy Control Allergy Control Allergy Control Allergy Control Allergy Control Allergy Control Allergy Control Allergy Control Allergy Control
Specific Uses For Product Allergy, Itch Relief Allergy Allergy Temporarily relieves these symptoms due to hay fever or other upper respiratory allergies: Runny nose Sneezing Itchy, watery eyes Itching of the nose or throat Temporarily relieves these symptoms due to the common cold: Runny nose Sneezing Allergy Allergy Relief, Fever, Runny Nose, Cold, Itchy Throat, itchy/watery eyes, sneezing, and itchy nose Allergy Allergy Allergy Allergy
Item dimensions L x W x H 2 x 1.25 x 3.75 inches 2.1 x 2.1 x 4.25 inches 1.75 x 3.5 x 4.75 inches 1.69 x 3.31 x 1.75 inches 3.56 x 1.63 x 3.81 inches 1.87 x 1.87 x 3.94 inches 7.8 x 6.3 x 2.8 inches 1.88 x 5.53 x 4.97 inches - 3.76 x 1.55 x 3.08 inches
Item Weight 0.09 Ounces - - 1.6 ounces 1.07 ounces 0.19 Ounces 0.31 Pounds - - 0.01 Ounces
FTB Score
ftb score rating icon 9.9
ftb score rating icon 9.8
ftb score rating icon 9.6
ftb score rating icon 9.5
ftb score rating icon 9.4
ftb score rating icon 9.2
ftb score rating icon 9.2
ftb score rating icon 9.1
ftb score rating icon 9.1
ftb score rating icon 9.1
Where to Buy