Best Squalane Face Serums of 2025

The Ordinary Retinol Serum is a powerful anti-aging treatment that helps you achieve smoother and more youthful skin. With a potent 1% retinol concentration, it effectively targets fine lines, wrinkles, and uneven texture. This formula not only improves your skin's tone but also nourishes it with squalane, which combats dryness often caused by retinol. Ideal for those who have already built a tolerance to lower-strength retinoids, this serum is perfect for users ready to take their skincare routine to the next level. Just remember to apply it in the evening and protect your skin with sunscreen during the day.

The Biossance Hydrating Face Serum offers you instant and lasting hydration, making it perfect for dry skin. With its unique blend of hyaluronic acid, polyglutamic acid, and squalane oil, it helps to plump and firm your skin, giving you a more youthful appearance. This serum also works to combat fine lines and wrinkles, thanks to vegan copper peptides that enhance your skin's elasticity. Additionally, the inclusion of Paracress Extract helps to lift and firm your skin right after application, providing immediate visible improvements.

Eva Naturals Retinol Serum with 1% Squalane is a powerful anti-aging serum that minimizes wrinkles, prevents sun damage, and fades dark spots. The 1% retinol formula reduces fine lines, wrinkles, sun spots, and hyperpigmentation while firming the skin. With hydrating squalene, it replenishes the skin's moisture barrier and provides long-lasting hydration for a healthy glow. This silky lightweight night serum absorbs quickly, boosts collagen, and improves skin tone. Suitable for all skin types, it's cruelty-free, paraben-free, fragrance-free, and alcohol-free, making it one of the best face serums available.

DERMA E Ultra Hydrating Dewy Skin Serum is a natural facial serum that plumps skin with moisture and nutrients. Clinically proven, it rejuvenates skin by supporting natural barrier protection and long-lasting moisture for up to 72 hours. The all-natural formula contains anti-aging Squalane, Hyaluronic Acid, Ceramides, and Mica, making skin softer, smoother, and more radiant. It's perfect for daily use to achieve glowing skin, and it's compatible with other DERMA E moisturizers. DERMA E is a 100% vegan and cruelty-free brand, offering clean beauty products with no harmful chemicals or additives.

Biossance Squalane + Lactic Acid Resurfacing Night Serum is a gentle yet powerful AHA exfoliant that dissolves dead skin cells. The product minimizes signs of aging, giving you a smoother, softer texture, visibly diminished fine lines, and a brighter complexion. Made with vegan lactic acid, squalane, and clover, the serum is a natural and proven solution to renew your skin. The serum is part of your daily nontoxic skincare routine, and it is vegan, cruelty-free, and made without parabens or synthetic fragrances or PEG.

The Findley Face Serum is designed to hydrate and firm your skin, giving you a radiant and youthful appearance. Infused with Vitamin C, this serum not only locks in moisture but also provides powerful antioxidant protection, helping to keep your skin looking fresh. Along with Rose Oil, it works to reduce fine lines and wrinkles, making your skin appear smoother and more vibrant. Additionally, the inclusion of Squalane ensures that your skin feels calm and soothed, while also addressing dark spots and improving texture. Experience the benefits of revitalized skin with this nourishing formula.

The MIZEEYE Retinol Serum is designed to deeply moisturize your skin, helping to combat dryness and enhance its overall texture. With its lightweight formula, this serum effectively reduces fine lines and acne, providing essential nutrients and hydration. It also works to minimize pores and excess oil, keeping your skin fresh and comfortable. Suitable for all skin types, this serum offers long-lasting moisture, making your skin smoother and more elastic. For optimal results, simply apply a few drops daily and massage until fully absorbed.

The ITK Hydrating Serum is designed to visibly enhance your skin’s moisture and plumpness. With its lightweight formula, this serum combines Hyaluronic Acid, Squalane, and Niacinamide to deeply hydrate and brighten your complexion. You’ll find that Niacinamide works to reduce dark spots, while Hyaluronic Acid helps to maintain optimal moisture levels in your skin. Squalane is included to soothe redness, making this serum perfect for sensitive and dry skin types. Plus, it's dermatologist-tested, ensuring it’s suitable for everyone.

The Aromixe Plumping Serum features a unique formula that provides quick and lasting hydration, making it perfect for anyone looking to boost their skin's moisture levels. This lightweight serum absorbs easily into the skin without leaving a sticky residue. It also incorporates copper peptides, which support the production of collagen and elastin, helping you achieve firmer and smoother skin. Additionally, the multi-acid blend of hyaluronic acid, polyglutamic acid, and sugarcane squalane works together to deeply hydrate and plump your skin, making it an ideal choice for both morning and evening skincare routines.

The Findley Vitamin C Serum combines the power of hydration and protection for your skin. With its Vitamin C content, you can enjoy a moisturizing experience that revitalizes your complexion. The addition of squalane helps to lock in moisture, ensuring your skin stays hydrated throughout the day. You’ll also appreciate the pleasant rose scent, which adds a lovely aroma to your skincare routine. This unisex formula is suitable for all skin types, making it a versatile choice for anyone looking to enhance their skincare game.