Best Squalane Face Serums of 2026

The Ordinary Retinol 0.5% is a face serum designed for users with some experience using retinol. Its moderate-strength formula helps reduce fine lines and wrinkles, making your skin look smoother and more youthful. This serum also works to even out your skin’s texture and tone, tackling common signs of aging caused by collagen and elastin loss. Infused with squalane, it nourishes and hydrates your skin, which helps prevent dryness often linked to retinol use. If you’ve built tolerance to gentler retinols, this product offers a balanced step before moving to stronger options.

The Ordinary Retinol Serum is a powerful anti-aging treatment that helps you achieve smoother and more youthful skin. With a potent 1% retinol concentration, it effectively targets fine lines, wrinkles, and uneven texture. This formula not only improves your skin's tone but also nourishes it with squalane, which combats dryness often caused by retinol. Ideal for those who have already built a tolerance to lower-strength retinoids, this serum is perfect for users ready to take their skincare routine to the next level. Just remember to apply it in the evening and protect your skin with sunscreen during the day.

The Ordinary Gentle Retinol is a mild formula designed to help reduce fine lines, wrinkles, and uneven skin tone, making your skin look smoother and more youthful. It includes squalane, which nourishes and hydrates your skin, helping to prevent the dryness that sometimes comes with retinol use. This serum is perfect if you’re new to retinol, offering a gentle start before moving on to stronger versions. Additionally, it works to improve your skin’s texture and tone, addressing signs of aging caused by the natural loss of collagen and elastin. It’s a simple way to care for your skin and maintain a healthy glow.

BYOMA Hydrating Serum is a hydrating facial serum designed to boost and repair your skin's barrier. With its powerful combination of ceramides, squalane, and glycerin, this serum delivers instant hydration and long-lasting results. It helps minimize trans-epidermal water loss, reducing redness, dryness, and flakiness, and promotes healthier daily skin function. Your skin will feel instantly smooth, soft, and nourished. This lightweight serum replenishes moisture levels, leaving your skin glowing and bouncy, while strengthening your skin's barrier function. It is dermatologist tested and approved, alcohol and fragrance-free, and suitable for all skin types. BYOMA Hydrating Serum is the ultimate skin-compatible solution, driven by science and powered by actives.

The L'Oreal Collagen Glow Serum is designed to deeply hydrate your skin for up to 72 hours, thanks to its blend of 8% pure collagen, glycerin, and squalane. This combination helps keep your skin bouncy and radiant, giving you an instant glow with its smooth, milky texture. The collagen in the serum is carefully purified to maintain its moisture-boosting effects, while squalane nourishes your skin, and glycerin locks in hydration. You’ll notice immediate hydration and brightness, with dry fine lines reducing in just one week and plumper, healthier-looking skin after four weeks. This lightweight, non-greasy formula absorbs quickly and works well on its own or under makeup.

Biossance Plumping Serum is a facial serum that provides immediate and lasting hydration to your skin. Its proprietary Rapid Plumping Complex floods your skin with three super-hydrators for supreme moisture, creating a bounce in a bottle. This non-sticky, silky blue elixir glides onto your skin and is absorbed, supplying more hydration than traditional hyaluronic acid serums that can't maintain moisture. It's perfect for your daily skincare routine, and you can use it morning and night. As part of Biossance's commitment to high standards for your skin and the environment, all products are vegan, cruelty-free, and made without paraben or synthetic fragrances or PEG.

The Biossance Firm & Lift Serum is designed to help you achieve firmer and more lifted skin by deeply hydrating and reducing the appearance of fine lines and wrinkles. It uses a special mix of ingredients like Gravetye Giant to give your skin a youthful, sculpted look. This serum also protects your skin from environmental damage, helping to keep it calm, even-toned, and resilient against pollution. Plus, it provides intense moisture with Hyaluronic Acid, leaving your skin plump and glowing. If you have sensitive or mature skin, the serum’s soothing ingredients help reduce redness and irritation, making your skin feel nourished and balanced every day.

The Purifect Squalane Face Serum is a hydrating formula designed to refresh and smooth your skin. It uses 96% plant-based squalane to deeply moisturize and improve your skin’s texture, helping to soften rough and dry areas. With antioxidant-rich Vitamin E and collagen-supporting Arginine, this serum boosts your skin’s firmness and elasticity, reducing fine lines for a healthier, youthful look. Made with gentle plant ingredients like lavender and sunflower seed oil, it’s safe for sensitive skin and free from harsh chemicals. You can easily add it to your daily routine, applying it morning and night for a radiant, hydrated complexion.

Eva Naturals Retinol Serum with 1% Squalane is a powerful anti-aging serum that minimizes wrinkles, prevents sun damage, and fades dark spots. The 1% retinol formula reduces fine lines, wrinkles, sun spots, and hyperpigmentation while firming the skin. With hydrating squalene, it replenishes the skin's moisture barrier and provides long-lasting hydration for a healthy glow. This silky lightweight night serum absorbs quickly, boosts collagen, and improves skin tone. Suitable for all skin types, it's cruelty-free, paraben-free, fragrance-free, and alcohol-free, making it one of the best face serums available.

The TruSkin Vitamin C-Plus Super Serum is a highly concentrated age-defying serum that promotes and prolongs a youthful and healthy-looking complexion. The advanced formula is powered by a synergistic blend of Vitamin C, Retinol, Niacinamide, Botanical Hyaluronic Acid, Salicylic Acid, and nourishing plant extracts, making it great for all skin types. The silky smooth formula is gentle and easy to incorporate into your skin care routine, and it is cruelty-free and manufactured in the USA. Plus, it comes with a 90-day money-back refund.