Best Argireline Face Serums of 2026

Lisa Bechard Avatar
Lisa Bechard
Last Updated: Jan 16, 2026

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Argireline face serums are a popular choice for those looking to reduce the appearance of fine lines and wrinkles. This powerful ingredient works to relax facial muscles, leading to a smoother, more youthful complexion. These serums are lightweight and easily absorbed, making them a great addition to any skincare routine. With regular use, users may notice a visible improvement in the look of their skin, helping them to achieve a more radiant and youthful appearance.

At a Glance: Our Top Picks

The Ordinary Argireline Solution 10% Cover #TOP 1
The Ordinary Argireline Solution 10%
ftb score rating icon 9.9
Asterwood Argireline Peptide w/Hyaluronic Acid Serum Cover #TOP 2
Asterwood Argireline Peptide w/Hyaluronic Acid Serum
ftb score rating icon 9.8
Asterwood Anti-Aging Serum Cover #TOP 3
Asterwood Anti-Aging Serum
ftb score rating icon 9.6

Top 10 Argireline Face Serums

#TOP 1

The Ordinary Argireline Solution 10%

769915195644
Clear
1 Fl Oz (Pack of 1)
The Ordinary Argireline Solution 10% Cover
The Ordinary Argireline Solution 10%, Serum Good for Reducing the Appearance of Fine Lines, 1 Fl Oz

The Ordinary Argireline Serum is designed to help reduce the appearance of fine lines and wrinkles. This non-injectable solution targets specific areas like your forehead, around the eyes, and smile lines, promoting a smoother and more relaxed look. Its advanced formula contains a potent 10% Argireline peptide solution, which is effective in softening deep-set lines. Being a lightweight, water-based serum, it easily absorbs into your skin, making it perfect for daily application. You can conveniently apply a few drops in the morning and evening for the best results.

What We Like
Reduces fine lines and wrinkles
Lightweight and fast-absorbing
Non-irritating, suitable for sensitive skin
Affordable anti-aging option
Plumps and firms skin
What We Don't Like
A bit watery texture
Slight stickiness for some users
#TOP 2

Asterwood Argireline Peptide w/Hyaluronic Acid Serum

Argireline Serum 1 oz
Argireline Peptide
1 Fl Oz (Pack of 1)
Asterwood Argireline Peptide w/Hyaluronic Acid Serum Cover
Asterwood Argireline Serum with Hyaluronic Acid - Peptide Serum for Face - Wrinkle Reducing, Anti-Aging, Nourishing - Fragrance-Free - 1 Fl Oz

Asterwood Argireline Serum is a powerful facial serum that helps smooth wrinkles, improve elasticity, brighten the skin, and keep it hydrated for a youthful and radiant complexion. The Argireline peptides promote collagen production, reducing the appearance of wrinkles, while the hyaluronic acid keeps the skin moisturized. With its small and convenient size, this serum is perfect for travel, making it easy to maintain your skincare routine wherever you go. It is also a great gift for your loved ones. Moreover, this peptide serum is free of harmful ingredients like fragrance, parabens, oils, and sulfates, ensuring it won't irritate your skin or cause breakouts. Made in the USA, it is safe to use with vitamin C serum, face cream, and face oils. All of Asterwood Naturals' facial skin care products are vegan and cruelty-free.

What We Like
Instant wrinkle smoothing effect
Improves skin texture and tone
Encourages collagen production
Brightens and hydrates skin
Good value for quality
What We Don't Like
Occasional packaging or fill issues
#TOP 3

Asterwood Anti-Aging Serum

Matrixyl 3000 + Argireline + Vitamin C 1
Triple Repair
1 Fl Oz (Pack of 1)
Asterwood Anti-Aging Serum Cover
Asterwood Triple Repair Matrixyl 3000 + Argireline + Hyaluronic Acid + Vitamin C Serum for Face - Anti-Aging, Collagen Boosting, Hydrating - Fragrance-Free - 1 Fl Oz

The Asterwood Face Serum is designed to rejuvenate your skin, providing essential hydration and protection. With its powerful ingredients, it helps prevent wrinkles and loss of collagen, allowing you to maintain a youthful appearance. The serum also repairs damage caused by aging and sun exposure, thanks to a blend of hyaluronic acid, Argireline, and Vitamin C. This combination locks in moisture and stimulates collagen production, making it a great addition to your nighttime skincare routine for revitalized skin.

What We Like
Improves skin glow
Reduces fine lines
Good value for money
Fast absorption
Works well with other products
What We Don't Like
Possible batch inconsistency
Might be drying for some
#TOP 4

Eva Naturals Matrixyl 3000 Serum

ENM3S
2 Fl Oz (Pack of 1)
Eva Naturals Matrixyl 3000 Serum Cover
Eva Naturals Matrixyl 3000 & Argireline Peptide Serum for Face – Anti-Aging Collagen Booster with Vitamin C & Hyaluronic Acid – Reduces Appearance of Fine Lines, Smooths, Hydrates & Firms - 2 Fl Oz

Eva Naturals Matrixyl 3000 Serum is a powerful peptide serum designed to boost collagen, prevent wrinkles, protect the skin, and improve elasticity. The collagen-boosting formula promotes firmer and more youthful-looking skin. By preventing wrinkles and stimulating collagen production, it helps maintain a youthful appearance. The addition of Vitamin C provides antioxidant protection and reduces dark spots for a healthy, radiant complexion. Furthermore, it improves skin elasticity, reducing signs of aging and resulting in even skin tone and texture. This serum offers convenient solutions for maintaining youthful and radiant skin.

What We Like
Lightweight, non-greasy texture
Quick absorption
Hydrating and moisturizing effect
Gentle for sensitive skin
Improves skin texture and tone
What We Don't Like
Slightly sticky for some users
Occasional mild scent issue
#TOP 5

SKIN DEVA Argireline Serum with Matrixyl 3000 and Hyaluronic Acid

B07FDN2FV6
1 Fl Oz (Pack of 1)
SKIN DEVA Argireline Serum with Matrixyl 3000 and Hyaluronic Acid Cover
SKIN DEVA 20% Argireline Serum with Matrixyl 3000 Pure Hyaluronic Acid Serum For Face Deep Wrinkle Reducer Anti Aging Tones Skin and Stimulates Collagen Peptides Serum For Face

SKIN DEVA Argireline Serum is a facial serum that reduces wrinkles and tones the skin. It consists of Argireline, Matrixyl 3000, and Hyaluronic Acid which penetrate deeper layers of skin to increase collagen production and synthesis. This non-greasy water-based serum keeps your skin hydrated all day long, reducing wrinkles, crow's feet, cutaneous photodamage, and making your skin tight.

What We Like
Visible fine line reduction
Lightweight and fast-absorbing
Hydrating and plumping effect
No pilling with other skincare
High concentration argireline
What We Don't Like
May cause mild irritation
Slightly tacky texture
#TOP 6

Asterwood Matrixyl 3000 Serum

Matrixyl 3000 + Argireline Serum 1 oz
1 Fl Oz (Pack of 1)
Asterwood Matrixyl 3000 Serum Cover
Asterwood Matrixyl 3000 + Argireline Serum for Face - Multi Peptide Serum with Hyaluronic Acid - Anti-Aging, Wrinkle Reducing, Collagen Boosting - Fragrance-Free - 1 Fl Oz

The Asterwood Anti-Aging Serum is designed to enhance your skin's resilience and youthful glow. With its advanced formula, it provides deep hydration, helping to combat wrinkles and promote collagen production. This serum works to repair skin damage while ensuring your complexion remains smooth and firm. Suitable for all skin types, it is gentle and free from harmful ingredients, making it an excellent addition to your nighttime skincare routine. Just a few drops can help rejuvenate your skin, providing the care it needs to look its best.

What We Like
Deep hydration
Lightweight texture
Reduced fine lines
Gentle for sensitive skin
Convenient single product
What We Don't Like
Occasional inconsistent texture
Might cause dryness for some
#TOP 7

HBM Huibo Medical 20% Argireline Serum

1 Fl Oz (Pack of 1)
HBM Huibo Medical 20% Argireline Serum Cover
PAPABA 20% Argireline Serum with Matrixyl 3000 Pure Hyaluronic Acid For Face,With Vitamin C,Deep Wrinkle Reducer Anti Aging Tones Skin and Stimulates Collagen Peptides Serum For Face

Experience remarkable results with the HBM Argireline Serum. Reduce wrinkles, increase collagen production, and achieve smooth, young skin with the powerful peptide complex of Matrixyl 3000 and argireline. The hyaluronic acid brings refreshing glow and locks in essential moisture, keeping your skin hydrated all day long. This non-greasy water-based serum is a must-have in your daily routine for reducing wrinkles, crow's feet, and cutaneous photodamage, ultimately tightening your skin.

What We Like
Noticeable wrinkle reduction
Skin tightening effect
Good value for money
Quick visible results
Non-irritating formula
What We Don't Like
Slight stickiness for some users
Mixed results for effectiveness
#TOP 8

Asterwood Triple Repair Anti-Aging Serum

Matrixyl 3000 + Argireline + Vitamin C 2
Triple Repair
2 Fl Oz (Pack of 1)
Asterwood Triple Repair Anti-Aging Serum Cover
Asterwood Triple Repair Matrixyl 3000 + Argireline + Hyaluronic Acid + Vitamin C Serum for Face - Anti-Aging, Collagen Boosting, Hydrating - Fragrance-Free - 2 Fl Oz

The Asterwood Triple Repair Serum is designed to help you achieve firmer and younger-looking skin by combining powerful ingredients like Matrixyl 3000, Argireline peptides, and Vitamin C. This serum works to reduce wrinkles and smooth expression lines, targeting common trouble spots like crow’s feet and laugh lines. It also supports your skin’s natural collagen production and improves hydration, thanks to Vitamin C and Hyaluronic Acid, giving you a radiant and healthy complexion. Plus, it’s gentle enough for daily use, free from harsh chemicals, making it a convenient and effective addition to your skincare routine.

What We Like
Noticeable skin glow
Improves firmness and smoothness
Great value for price
Absorbs quickly
Works well with other products
What We Don't Like
Occasional drying for some users
Batch-to-batch consistency issues
#TOP 9

Asterwood Triple Repair Serum for Face

Matrixyl 3000 + Argireline + Vitamin C 8
Triple Repair
8 Fl Oz (Pack of 1)
Asterwood Triple Repair Serum for Face Cover
Asterwood Triple Repair Matrixyl 3000 + Argireline + Hyaluronic Acid + Vitamin C Serum for Face - Anti-Aging, Collagen Boosting, Hydrating - Fragrance-Free - 8 Fl Oz

Looking for a high-quality anti-aging face serum? Try Asterwood Triple Repair Serum for Face - a perfect blend of Matrixyl 3000, Argireline, and Hyaluronic Acid with Organic Vitamin C. It strengthens your skin's defense, prevents wrinkles and collagen loss, and repairs damage caused by aging and sun exposure. It is safe for all skin types, free of harmful ingredients, and made in the USA. Use it as a part of your nighttime skincare routine and enjoy the hydrating and anti-aging benefits.

What We Like
Noticeable skin glow
Improves firmness and smoothness
Great value for price
Reduces fine lines
Works well with other products
What We Don't Like
Occasional product consistency variation
Might cause dryness for some
#TOP 10

DERMA CLINICALS Matrixyl 3000 + Argireline Serum

8 Fl Oz (Pack of 1)
DERMA CLINICALS Matrixyl 3000 + Argireline Serum Cover
Matrixyl 3000 + Argireline, Vitamin C, Hyaluronic Acid Serum, Anti-Aging Face Serum, Anti-Wrinkle Serum for face, Multi Peptide Firming Serum - 8oz

DERMA CLINICALS Anti-Aging Serum combines powerful ingredients to help you maintain youthful skin. Matrixyl 3000 supports collagen production, which helps repair and renew your skin, reducing signs of aging like fine lines. Argireline acts like a natural botox, relaxing facial muscles to smooth out wrinkles and soften your expression. Vitamin C is a strong antioxidant that protects your skin from damage, brightens your complexion, and boosts collagen to improve firmness. Together, these ingredients work to hydrate, firm, and refresh your skin, making it easier for you to achieve a smooth, radiant look.

What We Like
Hydrates and plumps skin
Reduces fine lines
Lightweight, fast-absorbing texture
Affordable and long-lasting
Suitable under makeup
What We Don't Like
Minimal effect on wrinkles
Buying Guide Image

Frequently Asked Questions (FAQs)

1. What cannot be used with Argireline?

Argireline should not be used with direct acids like L-ascorbic acid (Vitamin C) or ethylated ascorbic acid (EAA). It is important to avoid combining Argireline with these ingredients to prevent any potential adverse reactions.

2. Is Argireline better than retinol?

Argireline is considered more effective than retinol, vitamin C, and hyaluronic acid in reducing wrinkle depth and volume. It also has fewer side effects and is suitable for all skin types. Argireline stimulates collagen production and protects the skin from damage, making it a beneficial ingredient in anti-aging skincare routines.

3. What works better than Argireline?

While Argireline is effective, Snap-8 has been shown to be 30% more effective than Argireline in reducing wrinkle depth. Snap-8 also provides better results in reducing the depth of wrinkles. However, Argireline is still considered an excellent alternative to botulinum toxin and works by releasing neurotransmitters at the terminal end of snap-25.

4. What are the risks of Argireline?

Argireline is generally safe to use, but individuals with sensitive skin may experience stinging, redness, and dry flaky skin at the application sites. It is advised not to apply peptide-containing products, including Argireline, to sunburned or irritated skin to avoid further irritation.

5. Is Argireline safe to use under eyes?

Yes, Argireline is safe to use around the eyes. It promotes collagen production and improves the function of collagen, which helps smooth out wrinkles caused by repeated muscle movement in areas like the forehead and around the eyes. Argireline is suitable for anyone looking to address fine lines in these areas.

6. Can I use vitamin C and Argireline together?

It is generally not recommended to directly mix ascorbic acid (pure Vitamin C) with peptides like Argireline. Vitamin C may not combine well with skincare ingredients such as niacinamide and retinoids. However, depending on your skin's sensitivity and tolerance, you may use both Vitamin C and Argireline separately in your skincare routine.

7. Which is better Matrixyl or Argireline?

Matrixyl and Argireline serve different purposes in anti-aging skincare. Matrixyl improves skin structure and reduces wrinkles, while Argireline focuses on specific areas prone to dynamic wrinkles caused by facial expressions. Both ingredients can be beneficial when used together in a comprehensive anti-aging skincare regimen.

Editor's Notes

During our argireline face serum research, we found 48 argireline face serum products and shortlisted 10 quality products. We collected and analyzed 160,179 customer reviews through our big data system to write the argireline face serums list. We found that most customers choose argireline face serums with an average price of $19.52.

The argireline face serums are available for purchase. We have researched hundreds of brands and picked the top brands of argireline face serums, including The Ordinary, Asterwood, Eva Naturals, SKIN DEVA, PAPABA. The seller of top 1 product has received honest feedback from 384 consumers with an average rating of 4.7.

Written by
Lisa Bechard Avatar

Lisa Bechard is a skin therapist with 12 years of working experience in the beauty industry and also an experienced beauty writer who has expertise in skincare, medical aesthetics and cosmetic surgery, and wellness. Her writing skills are excellent and all her content is very persuasive and insightful.

Argireline Face Serums Comparison Table

#TOP1
#TOP2
#TOP3
#TOP4
#TOP5
#TOP6
#TOP7
#TOP8
#TOP9
#TOP10
Brand The Ordinary Asterwood Asterwood Eva Naturals SKIN DEVA Asterwood PAPABA Asterwood Asterwood DERMA CLINICALS
Skin Type - All All, Combination, Dry, Normal, Sensitive All, Combination, Dry, Mature Skin, Sensitive Combination, Dry, Normal, Oily All All All, Combination, Dry, Normal, Sensitive All, Combination, Dry, Normal, Sensitive All
Product Benefits - Anti Wrinkle, Fine Line Treatment, Firming, Hydrating, Repairing, Tightening Anti Wrinkle, Anti-Aging, Brightening, Even Toning, Rejuvenating, Repairing Firming Anti-Aging Anti Wrinkle, Fine Line Treatment, Firming, Hydrating, Repairing, Tightening Hydrating Anti Wrinkle, Anti-Aging, Brightening, Even Toning, Rejuvenating, Repairing Anti Wrinkle, Anti-Aging, Brightening, Even Toning, Rejuvenating, Repairing Anti-aging,Anti-wrinkle,Brightening,Firming,Hydrating,Tightening
Scent - Fragrance Free Unscented Matrixyl Peptide no Fragrance Fragrance Free no Unscented Unscented Aloe
Special Ingredients - Argireline Peptide, Hyaluronic Acid Argireline, Hyaluronic Acid, Matrixyl 3000, Vitamin C Acetyle Hexapeptide-8, Aloe Vera, Hyaluronic Acid, Matrixyl 3000 (Tripeptide-1 + Tetrapeptide-7), Vitamin C (Sodium Ascorbyl Phosphate) Argireline, Hyaluronic Acid, Matrixyl 3000 Argireline, Hyaluronic Acid, Matrixyl 3000 alpha_hydroxy, collagen, glycolic_acid, hyaluronic_acid, vitamin_a Argireline, Hyaluronic Acid, Matrixyl 3000, Vitamin C Argireline, Hyaluronic Acid, Matrixyl 3000, Vitamin C antioxidants, collagen, hyaluronic_acid, vitamin_c
Use for - Face, Neck Face, Neck Face Face Face, Neck Face Face, Neck Face, Neck -
FTB Score
ftb score rating icon 9.9
ftb score rating icon 9.8
ftb score rating icon 9.6
ftb score rating icon 9.6
ftb score rating icon 9.4
ftb score rating icon 9.3
ftb score rating icon 9.3
ftb score rating icon 9.2
ftb score rating icon 9.2
ftb score rating icon 9.2
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