Best Argireline Face Serums of 2025

"As a 30-year-old Asian female, I was eager to try The Ordinary Argireline Solution 10% after hearing it called 'Botox in a bottle' by dermatologists. After my first use, I felt a subtle tightening effect—my skin was firmer yet stayed hydrated, which I truly appreciated. I'm excited to see how it helps with fine lines over time. So far, it's a fantastic addition to my skincare routine!"

"I've been using this faithfully for over a year now. As a 32-year-old woman who started my skincare journey at 30, I've seen dramatic improvements in my skin. Like others, I noticed that my skin looked better immediately, and it has only grown more radiant with continued use. I mix it with Matrixyl, and that combination is something I swear by. I use it morning and evening every day, and a bottle usually lasts me about 3 months. Consistency is key for this to work!"

"I had some forehead lines I wanted to smooth out, so after reading about Argireline Serum in a health magazine and seeing rave reviews, I decided to give it a shot. I was surprised to find that the serum was just a watery, runny liquid. I used it sometimes twice a day for a month, but I didn't see any great transformation—no plumping or smoothing. At this point, I’m not expecting much to happen. It’s been a bit of a disappointment, especially after all the hype!"

"I've ordered this several times and have finally pinpointed that this product is responsible for my skin’s glow. I’m reordering, but I’ll skip the vitamin C since I’m adding copper peptides at night. This thin serum is packed with peptides and has significantly improved my under-eye circles. I’m 58 and this product has been a game changer for my skin."

"I’ve been using this for two weeks and I can feel the difference. My skin is smoother and feels hydrated, with a slight glow. I truly believe this should be in every woman’s skincare routine."

"We’ve been using this for over a year, and it helps maintain moisture, especially overnight. While it hasn’t completely eliminated lines, it has definitely made our skin supple and refreshed. We keep ordering!"

"I've been using the Argireline Serum with Matrixyl 3000 and Hyaluronic Acid for a few weeks, and I'm genuinely impressed. This serum is a game-changer for reducing fine lines and hydrating my skin. I've noticed a reduction in fine lines around my eyes and forehead within a week. My skin feels firmer and plumper, and it looks fresh and dewy all day long."

"As someone approaching forty, I can confidently say this is my favorite wrinkle serum. It goes on light, even though it's thick, and there's no greasy feeling afterward. It glides on smoothly and absorbs well without any irritation, helping to calm my redness from rosacea. I truly appreciate my new glow thanks to this product!"

"I’ve consistently used this serum alongside tretinoin and have noticed significant improvements. My skin feels supple, and fine lines are diminishing! I’ll definitely be a repeat customer, especially since I found it for a fraction of the price advertised elsewhere."

"I use this product twice a day and my face feels very moisturized. I mix it with my sunscreen and notice no scent when applying."

"At 55, I've noticed a 50% decrease in sagging and wrinkles on my neck after a month of use. I'm also incorporating derma needling for better results!"

"I loved this product so much that I immediately ordered more. It leaves my skin feeling soft and hydrated throughout the day and doesn't interfere with my makeup."

"This product is amazing! I recently tried a Matrixyl and Argireline serum, and I am really impressed! The formula is lightweight and absorbs quickly without any greasy residue. I’ve noticed a subtle tightening effect on my skin, especially around my forehead and eyes, which is fantastic. Plus, it’s fragrance-free, making it ideal for my sensitivities. Just a tip, if the serum arrives open, it can spoil, so inspect it upon delivery. Luckily, mine was in perfect condition!"

"I've been using this product morning and night for a month and can see a visible difference in my skin. I started using it right before my vacation when I wasn't getting enough sleep or eating well, and to my surprise, my skin looked better than before my trip! It has improved my skin’s brightness and smoothness significantly, and I’m definitely continuing with this product due to its great price point."

"I love this product! It's moisturizing and smoothing, and it really improves my skin's tone and elasticity. I've signed up for automatic delivery to make sure I never run out!"

"I'm 18 and had pretty deep smile lines. After seeing all the positive reviews, I decided to give this a shot. These pictures show a month of improvement in my skin; my wrinkles have vanished, and my face feels smoother and more moisturized. This is definitely worth the price—and surprisingly, I wasn't even using it daily!"

"I appreciate this serum for its wrinkle-reducing effects. I primarily apply it on my forehead to soften those lines. It really works and is potent. I started using this brand after seeing a dermatologist recommend it on Facebook."

"I've been testing this for a few weeks now. I noticed a difference on the first day, but as time went on, the improvements became more evident. It feels slightly tacky but not unpleasant, and overall, I consider this a fantastic buy."

"I noticed that it improves my skin texture and reduces the appearance of my crow's feet. While it doesn't provide the full filling effect that some claim, it does seem to work for me."

"After doing a lot of research, I found that argireline is hit or miss for many people. Personally, I saw instant results after using it, especially on my nasolabial folds and neck. It gave my skin a plumping and smoothing effect."

"Initially, I was thrilled to see my nasolabial folds smoothed out, but when I smiled, I noticed a deep crease appearing below my nose. It seems to create compensatory effects in other areas of the face, which is something to watch for."

"After using this product for two months, I noticed an instant relaxing effect on my smoker's wrinkles and expression lines. I switched to another brand for added vitamin C due to my mature skin, but this product really does the trick! When I stop using it, my wrinkles worsen quickly. The price is right, so I’ll keep using it. Very good quality, I highly suggest it!"

"I've been using this serum for a few years now, and I saw a difference just a few months after starting. It’s truly a great product for mature skin; it has diminished fine lines and dark spots. I intend to continue using it as part of my daily routine."

"I just began using this serum for marionette lines and crepey skin around my jowls. I can feel it tightening the areas I’ve addressed. I’ll keep using it for 90 days to measure my progress, but so far, I’m optimistic!"

"As someone with SLE, my skin is often inflamed and damaged, but this product has healed deep scars and made my skin feel bouncy."

"I've noticed this serum is effective against lines and wrinkles. It doesn't take much to see improvements on my forehead and around my mouth."

"I appreciate the light texture of this sleek serum. It's easy to incorporate into my morning or nighttime skincare routine. I use the dropper on damp skin, and it absorbs quickly before my moisturizer. Although it's too soon to see changes, I'm excited for results from such an esteemed brand!"

"I LOVE THIS SERUM! It helps me combat those small wrinkles on my face, and I even believe it's aiding my deeper lines. Although I don't use it daily, the bottle suggests twice a day. At 56 years old, I've just begun my skincare journey, and I'm thrilled to have discovered this!"

"I think it's a decent product. I'm still waiting to notice results, but I appreciate that it's not too thick or sticky. It goes on nicely."

"I'm on my second bottle now and will definitely order again. It absorbs quickly without any stickiness, making it a great addition to my skincare routine."