Best Left-Handed Computer Mice of 2025

The Logitech Signature M650 L is a wireless mouse designed for left-handed users with larger hands. It features line-by-line precision for documents and fast scrolling for long web pages. The mouse's contoured shape, soft thumb area, and rubber side grips provide long hours of comfort. It connects via Bluetooth Low Energy or the Logi Bolt USB receiver and is compatible with multiple operating systems. The mouse is also customizable with Logitech Options+ software and features SilentTouch technology for 90% less click noise. The battery life is up to 2 years on a single AA battery.

The Logitech Lift Vertical Ergonomic Mouse is designed for small to medium left hands, providing all-day comfort and productivity. Its vertical shape promotes a more natural forearm posture, reducing strain and fatigue. The mouse features customizable buttons, quiet clicks, and easy scrolling for seamless work. It is ergo-certified, ensuring it meets leading ergonomists' criteria. The mouse can be connected wirelessly via Bluetooth Low Energy or Logi Bolt USB and works with various operating systems. It also uses certified post-consumer recycled plastic, making it eco-friendly.

The Perixx PERIMICE-713L Wireless Ergonomic Left Handed Vertical Mouse is designed specifically for left-handed users, providing a natural ergonomic grip that helps reduce muscle strain, making it perfect for those who work long hours on the computer. With its 6-button design, you can easily access multiple functions, increasing your productivity. The mouse offers three levels of sensitivity adjustment, allowing you to customize the DPI settings to your preference. Its wireless 2.4GHz technology provides up to 10 meters of operation range, giving you the freedom to move around. The mouse also features a power-saving function and comes with a USB receiver that can be conveniently stored at the bottom of the mouse. With its certified quality and compatibility with Windows operating systems, the Perixx Left Handed Vertical Mouse is a reliable and user-friendly choice for left-handed individuals.

The Urby Left Handed Mouse offers a user-friendly experience with its included batteries and simple plug-and-play setup. Designed specifically for left-handed users, its compact size is perfect for small to medium hands, ensuring comfort during extended use. This mouse features a stylish glossy and matte finish, moving away from the typical dark color schemes often seen in tech products. With a focus on customer satisfaction, Urby's USA-based support team is ready to assist you, giving you peace of mind with your purchase.

The ELECOM Left Hand Mouse is designed specifically for left-handed users, providing an ergonomic shape that promotes comfortable use. Its unique design positions the left click on the right side, allowing your index finger to easily manage essential functions. You can enjoy a quiet working environment with the silent click feature, perfect for meetings or late-night sessions. Additionally, the customizable buttons let you tailor the mouse to suit your specific needs, enhancing your productivity. This combination of comfort, quiet operation, and personalization makes it a great choice for anyone seeking a left-handed mouse.

The Urby Left Handed Mouse is designed specifically for left-handed users, featuring an ergonomic vertical shape that fits comfortably in small to medium hands. It comes with two AAA batteries for easy plug-and-play setup, allowing you to start using it right away without complicated installations. This mouse offers a stylish glossy and matte finish, departing from the typical black and neon designs. Additionally, it includes a Type C converter, addressing common compatibility issues, and is backed by USA-based customer service for any inquiries you may have.

The WishLotus Left-Handed Mouse is a unique and tailor-made mouse designed for left-handers. It features a transparent logo, matte process, and 800 DPI resolution, making it precise, flexible, and comfortable to use. The mouse is easy to use with its plug-and-play feature and requires no computer setup. The optical mouse with Agilent's original chip adds weight in the bottom of the mouse, providing better hand feel and stable performance.

This wireless mouse features an ergonomic vertical design that encourages a comfortable, healthy grip for less wrist strain. The thumb rests and grips are designed to fit the contour of your palm for maximum comfort, making this mouse perfect for small hands or those with RSI. It's easy to use, simply plug in the USB receiver and adjust the DPI to your needs. The automatic sleep function saves energy and the mouse is compatible with a variety of operating systems.

The Perixx Perimice-719L Left Handed Wireless Vertical Mouse is designed with small hands in mind, featuring wireless 2.4 GHz technology with a 10-meter operating range, an ergonomic design that encourages a natural handshake position to prevent repetitive strain injuries, and silent-click buttons that make it perfect for use in public places. The optical sensor and built-in DPI switch button allow you to switch between 800/1200/1600 DPI, and it is a plug-and-play mouse with a nano USB receiver. Compatible with Windows 7, 8, and 10, the package includes the PERIMICE-719, receiver, and a 12-month limited warranty.

The Urby Left Handed Mouse is designed with your comfort in mind. It comes with two AAA batteries included, allowing for a hassle-free wireless setup—just plug it in and play. This lightweight vertical mouse is perfect for medium to larger left hands, ensuring a comfortable grip during use. Unlike many other gaming mice, this model features a unique glossy and matte finish, steering clear of the typical black and neon designs. Plus, with USA-based customer service in California, you can count on support whenever you need it.