Best Ergonomic Computer Mice of 2025

The Logitech Lift Vertical Ergonomic Mouse is a great fit for small to medium right hands, with a softly textured grip and snug thumb rest for level-above cosiness. It features easy-to-reach customisable buttons, whisper-quiet clicks and a SmartWheel for smooth, seamless scrolling. Connect via Bluetooth Low Energy or Logi Bolt USB to Windows, macOS, iPadOS, Chrome OS, or Linux, and enjoy up to 2 years battery life.

The Anker Wireless Vertical Ergonomic Optical Mouse is the perfect choice for those who spend long hours using a computer. Its ergonomic design encourages a healthy, neutral wrist and arm position, reducing overall strain. With 800/1200/1600 DPI resolution optical tracking technology, it provides precise tracking on a wide range of surfaces. The added next/previous buttons make web browsing more convenient. Additionally, it enters power-saving mode after 8 minutes idle, saving battery life. The package includes one Anker Wireless Vertical Ergonomic Optical Mouse, one 2.4G USB receiver, and one instruction manual.

The TECKNET Wireless Mouse is an ergonomic mouse with a contoured shape and soft rubber grip for all-day comfort. It features a Plug & Play USB Nano receiver, 5 adjustable DPI levels, Tru-Wave Technology, a smart auto-sleep mode, and up to 24 months of battery life. It is compatible with Windows, Mac OS, and Linux, and comes with 36 months of support.

The Anker Ergonomic Optical USB Wired Vertical Mouse is designed with scientific ergonomic principles that encourage a healthy wrist and arm position, reducing overall strain. Its 1000/1600 DPI Resolution Optical Tracking Technology provides more sensitivity than standard optical mice. The added next/previous buttons offer convenience when webpage browsing, making it the superior choice for internet surfers, gamers, and people who work long hours at the computer. With a 1.5m/4.9ft USB cable length, the product is compact and easy to use.

The TECKNET Vertical Mouse offers seamless connectivity options, allowing you to switch between Bluetooth and 2.4GHz modes effortlessly. This means you can connect to multiple devices without sacrificing USB ports, making it perfect for modern laptops. With six adjustable DPI settings, you can customize sensitivity for different tasks, enhancing your workflow. The silent operation ensures you can work in quiet environments without disturbing others. Designed for ergonomics, this mouse promotes a natural wrist position, reducing strain during extended use, making it an ideal choice for anyone who spends long hours on the computer.

The Logitech MX Vertical Wireless Mouse is designed with a unique 57-degree angle, placing your hand in a natural handshake position to reduce muscular strain by 10%. Its hyper-efficient 4000 DPI high-precision sensor provides precise tracking that requires 4x less hand movement compared to a traditional mouse with a 1000 DPI sensor. With cross-computer control, you can navigate seamlessly on three computers and copy-paste text, images, and files from one to the other using Logitech FLOW. The mouse can be connected via included wireless USB unifying receiver or Bluetooth smart technology or the included USB-C charging cable. The rechargeable battery lasts for 4 months on a full charge, and you can get 3 hours of use from a 1-minute quick charge.

The ProtoArc Bluetooth Mouse is designed with your comfort in mind. Its ergonomic shape includes an extended wrist rest, promoting a natural hand position that helps reduce fatigue during long hours of use. You can easily connect this mouse to up to three devices simultaneously, making it perfect for multitaskers. With adjustable DPI levels, you gain enhanced precision for various tasks, while the rechargeable battery ensures you won't run out of power unexpectedly. Enjoy a quieter workspace with its silent clicking feature, allowing you to focus without distractions.

The Logitech Ergo M575 Wireless Trackball is a wireless trackball with a sculpted ergonomic shape that reduces fatigue in your hand and arm. The smooth and responsive thumb control can be used anywhere, making it perfect for tight desk spaces. With two ways to connect - via Bluetooth Low Energy or the included USB receiver - the ERGO M575 provides a powerful, reliable signal from up to 10 m away. The plastic parts in this trackball include post-consumer recycled plastic - 50% for Graphite and 21% for Off-white - to give a second life to end-of-life plastic.

The Amazon Basics Ergonomic Wireless PC Mouse is a compact mouse that provides adjustable DPI (600, 1000, 1600, 2400, or 3600 DPI) for preferred sensitivity. The advanced optical sensor allows it to work on most surfaces, and it has a clickable metallic scroll wheel, back/forward thumb buttons for easily navigating web pages, and 2.4 GHz wireless connection with a 33-foot range. It has an ergonomic shape with rubberized sides for a comfortable hold, and it's compatible with Windows 7, 8, and 10. The mouse uses 1 AA battery (included) and has a sleek black color.

The Logitech ERGO M575 Wireless Trackball Mouse is an ergonomically designed mouse that offers smooth thumb control, precise tracking, and perfect for tight workspaces. It has two ways to connect and multi-OS capabilities, convenient controls, and up to 24-month of use from a single AA battery. It also features post consumer recycled plastic parts and FSC-certified paper for responsible packaging.