Best Liquid Antidiarrheal Medications of 2026

Bonnie Salem Avatar
Bonnie Salem
Last Updated: Jan 16, 2026

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Liquid antidiarrheal medications are a popular over-the-counter solution for those suffering from diarrhea. These medications work by slowing down the movement of the intestines, reducing the frequency of bowel movements and allowing the body to absorb more water and nutrients. Some common active ingredients found in these medications include loperamide and bismuth subsalicylate. It is important to follow the dosage instructions carefully, as overuse of these medications can lead to constipation and other side effects. It is also important to stay hydrated and seek medical attention if diarrhea persists for more than a few days.

At a Glance: Our Top Picks

Pepto Bismol Liquid Cover #TOP 1
Pepto Bismol Liquid
ftb score rating icon 9.9
Imodium A-D Liquid Oral Anti-Diarrheal Medicine Cover #TOP 2
Imodium A-D Liquid Oral Anti-Diarrheal Medicine
ftb score rating icon 9.8
Iberogast Liquid Drops Herbal Digestive Relief Cover #TOP 3
Iberogast Liquid Drops Herbal Digestive Relief
ftb score rating icon 9.6

Top 8 Liquid Antidiarrheal Medications

#TOP 1

Pepto Bismol Liquid

1299292831
Pepto Bismol Liquid Cover
Pepto Bismol Liquid, Upset Stomach Relief, Nausea Relief, Heartburn Relief, Indigestion Relief, Anti Diarrhea Medication for Adults - 5 Symptom Fast Relief, 2x12 oz (Packaging May Vary)

Pepto Bismol Relief is a trusted brand that has been providing fast relief for upset stomachs for over 100 years. Its coating action helps to calm the stomach and soothe the digestive system, effectively relieving symptoms such as nausea, heartburn, indigestion, upset stomach, and diarrhea. With Pepto Bismol Relief, you can experience relief from these uncomfortable symptoms, allowing you to get back to your day without interruption. As the #1 pharmacist recommended brand for upset stomachs, you can trust Pepto Bismol Relief to provide high-quality relief that you can count on.

What We Like
Fast-acting relief
Reliable for upset stomach
Convenient availability
Pleasant flavor
Easy dosing
#TOP 2

Imodium A-D Liquid Oral Anti-Diarrheal Medicine

300450134080
8 Fl Oz (Pack of 1)
Imodium A-D Liquid Oral Anti-Diarrheal Medicine Cover
Imodium A-D Liquid Anti-Diarrheal Medicine with Loperamide HCl to Help Control Symptoms of Diarrhea Due to Acute, Traveler's Diarrhea, Mint Flavor, 8 fl. oz

Imodium A-D liquid oral anti-diarrheal medicine comes in an 8-fluid ounce bottle with mint flavor, designed to work with your body to restore its natural rhythm and balance. Its proven formula helps control symptoms of diarrhea for fast, effective relief. It contains 1 mg of loperamide HCl in every 7.5 milliliters to help control symptoms of diarrhea due to acute, active and Traveler's diarrhea. It is easy to take, and it works faster than the leading prescription medication containing diphenoxylate and atropine.

What We Like
Works fast for effective relief
Proven formula helps control symptoms of diarrhea
Easy-to-take liquid formula with a refreshing mint flavor
#TOP 3

Iberogast Liquid Drops Herbal Digestive Relief

Iberogast
Brown
Iberogast Liquid Drops Herbal Digestive Relief Cover
Iberogast Liquid Drops, Herbal Relief of Stomach Upsets: Occasional Indigestion, Bloating, Gas, Nausea, Upset Stomach; Gluten Free; 6-Herb Blend with Iberis Amara, Peppermint, Licorice; 50mL

The Iberogast Herbal Digestive Relief is a natural herbal supplement designed to ease occasional stomach issues such as indigestion, nausea, bloating, and heartburn. It works by helping to restore normal digestive function, making it easier for your stomach to process food comfortably. The product is backed by clinical studies, so you can trust its effectiveness. Iberogast supports your digestive health in multiple ways: it helps lower excess stomach acid, regulates stomach muscle activity, soothes nerves in your gut, and promotes a healthy gut lining. Taking Iberogast daily can provide you with gentle, natural relief and support for your digestive system.

What We Like
Natural herbal blend
Clinically proven effectiveness
Relieves multiple stomach issues
Supports normal digestive function
Multi-action gut support
#TOP 4

A+Health Loperamide Hcl 2 Mg Softgels

Amazon Basic Care
LOP24
A+Health Loperamide Hcl 2 Mg Softgels Cover
Amazon Basic Care Loperamide Hcl 2 Mg Softgels, Anti-Diarrheal, 24 Count (Pack of 1)

A+Health Loperamide Softgels are an effective solution for controlling diarrhea. These softgels contain Loperamide Hcl 2mg, which is the active ingredient found in Imodium A-D. They are specially designed to help control the symptoms of diarrhea, including Travelers' Diarrhea. Made in the USA using ingredients from various countries, these liquid-filled capsules are easy to swallow, making them suitable for people who have difficulty swallowing. The softgels are suitable for adults and children 12 years and older, with each pack containing 24 softgels. The directions recommend taking 2 softgels after the first loose stool, followed by 1 softgel after each subsequent loose stool, with a maximum of 4 softgels in 24 hours. Stay hydrated by drinking plenty of clear fluids along with the softgels to alleviate diarrhea effectively.

What We Like
Fast-acting gel capsules
Affordable price
Works like name brand
Easy to swallow
Effective for stomach issues
#TOP 5

Pepto Bismol 5 Symptom Relief

149010000
4 Fl Oz (Pack of 1)
Pepto Bismol 5 Symptom Relief Cover
Pepto Bismol Liquid, Upset Stomach Relief, Nausea Relief, Heartburn Relief, Indigestion Relief, Anti Diarrhea Medication for Adults - 5 Symptom Fast Relief, 4 oz (Packaging May Vary)

Pepto Bismol Stomach Relief is designed to tackle five common stomach issues: nausea, heartburn, indigestion, upset stomach, and diarrhea. Its unique coating action helps calm your stomach and soothes your digestive system, providing quick relief just like Pepto Bismol Liquid. With a century of trusted service, you can rely on Pepto Bismol for effective treatment of upset stomachs. As the #1 recommended brand by pharmacists, you can feel confident in its quality and effectiveness for your digestive discomfort.

What We Like
Effective for multiple symptoms
Fast-acting relief
Trusted for over 100 years
Pharmacist recommended
#TOP 6

Kaopectate Multi-Symptom Relief Caplets

20570
Kaopectate Multi-Symptom Relief Caplets Cover
Kaopectate Multi-Symptom Anti-Diarrheal& Upset Stomach Reliever, 42 Caplets

Kaopectate Multi-Symptom Relief Caplets provide fast, temporary relief from seven types of stomach discomfort, including diarrhea, nausea, indigestion, gas, and more. Its trusted formula includes Bismuth subsalicylate, a proven antacid ingredient that targets the source of your symptoms. With easy, on-the-go relief, you can take Kaopectate caplets anywhere and trust in its medical solutions for your GI discomfort.

What We Like
Fast relief from stomach discomfort
Easy, on-the-go caplets
Trusted formula with Bismuth subsalicylate
#TOP 7

Pepto Bismol Liquid 8 oz

PPAX1194570
Pink
8 Fl Oz (Pack of 1)
Pepto Bismol Liquid 8 oz Cover
Pepto Bismol Liquid, Upset Stomach Relief, Nausea Relief, Heartburn Relief, Indigestion Relief, Anti Diarrhea Medication for Adults - 5 Symptom Fast Relief, 8 oz (Packaging May Vary)

The Pepto Bismol Stomach Relief offers fast help when your stomach feels off, so you don’t have to stop your day. This medicine targets five common stomach issues all at once: nausea, heartburn, indigestion, upset stomach, and diarrhea. It uses one strong ingredient that works effectively whether you’re dealing with one problem or several. Plus, it coats your stomach to ease irritation and calm discomfort, giving you soothing relief you can notice. This makes it a handy choice to keep on hand for quick stomach comfort.

What We Like
Fast relief for five symptoms
Multi-symptom treatment
Single effective ingredient
Soothes and coats stomach
#TOP 8

Pepto-Bismol Regular Strength Liquid 32 oz (2x16 oz)

149003947
Pepto-Bismol Regular Strength Liquid 32 oz (2x16 oz) Cover
Pepto-Bismol Regular Strength Liquid - Total: 32 oz (16 oz X 2)

Pepto-Bismol Liquid comes in two convenient 16-ounce bottles, giving you a total of 32 ounces to keep on hand. This medication helps ease common digestive problems like heartburn and indigestion, so you can feel comfortable after meals. It also soothes upset stomachs and helps reduce nausea, providing quick relief when you’re not feeling your best. Additionally, it works to calm diarrhea, helping you get back to your daily routine faster. With Pepto-Bismol Liquid, you have a trusted solution to handle multiple stomach issues in one easy-to-use product.

What We Like
Dual 16-ounce bottles
Relieves heartburn
Soothes upset stomach
Reduces nausea
Treats diarrhea
Buying Guide Image

Frequently Asked Questions (FAQs)

1. What liquid medicine is good for diarrhea?

Two types of meds relieve diarrhea in different ways: Loperamide (Imodium) slows the movement of food through your intestines, which lets your body absorb more liquid. Bismuth subsalicylate (Kaopectate, Pepto-Bismol) balances out how fluid moves through your digestive tract.

2. Does Imodium come in liquid form?

IMODIUM® A-D Anti-Diarrheal Oral Solution (liquid) is the fastest single ingredient OTC medicine to help stop diarrhea, allowing you to get back to doing the things you love. With 1mg of Loperamide HCl per 7.5 mL, this product helps control the symptoms of diarrhea, including Travelers' Diarrhea.

3. Can you buy liquid Imodium over-the-counter?

You can buy loperamide from pharmacies and supermarkets or you can get it on prescription. Loperamide is available to buy without a prescription for: anyone aged 12 and older with short-term diarrhoea.

4. Is Imodium good for liquid diarrhea?

Imodium is often the go-to treatment for diarrhea and traveler's diarrhea. Loperamide, the active ingredient in Imodium, relieves diarrhea symptoms by slowing the digestive system back down to its normal rhythm.

Editor's Notes

During our liquid antidiarrheal medication research, we found 24 liquid antidiarrheal medication products and shortlisted 8 quality products. We collected and analyzed 231,701 customer reviews through our big data system to write the liquid antidiarrheal medications list. We found that most customers choose liquid antidiarrheal medications with an average price of $10.85.

The liquid antidiarrheal medications are available for purchase. We have researched hundreds of brands and picked the top brands of liquid antidiarrheal medications, including Pepto Bismol, Imodium, Iberogast, Kaopectate. The seller of top 1 product has received honest feedback from 384 consumers with an average rating of 4.7.

Written by
Bonnie Salem Avatar

Bonnie Salem is a stay-at-home mother with two-year-old twins and has spent almost half of her life surrounded by baby products. As a mother and a professional copywriter, she has an insightful and unique eye for researching products suitable for infants. Bonnie Salem is an expert in health and nutrition who lives with her family in New Jersey. She has over 15 years of working experience in an institute of medicine after graduating from the University of Toronto. She is highly interested in personal health and wellness.