Best Antidiarrheal Medications of 2026

Bonnie Salem Avatar
Bonnie Salem
Last Updated: Jan 16, 2026

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Antidiarrheal medications are designed to alleviate the symptoms of diarrhea, which can be caused by a variety of factors such as food poisoning, infection, or medication side effects. These medications work by slowing down the movement of the digestive tract, allowing the body to absorb more water and nutrients from the stool. Some common types of antidiarrheal medications include loperamide, bismuth subsalicylate, and attapulgite. It is important to note that while these medications can provide relief from diarrhea symptoms, they should not be used for extended periods of time without consulting a healthcare provider.

At a Glance: Our Top Picks

Amazon Basic Care Loperamide Hydrochloride Tablets Cover #TOP 1
Amazon Basic Care Loperamide Hydrochloride Tablets
ftb score rating icon 9.8
Imodium A-D Softgels for Diarrhea Relief Cover #TOP 2
Imodium A-D Softgels for Diarrhea Relief
ftb score rating icon 9.7
IBgard Peppermint Oil Gut Health Capsules Cover #TOP 3
IBgard Peppermint Oil Gut Health Capsules
ftb score rating icon 9.5

Top 10 Antidiarrheal Medications

#TOP 1

Amazon Basic Care Loperamide Hydrochloride Tablets

Amazon Basic Care
GETIEN-Y-GS-1201-390
Light Green
Amazon Basic Care Loperamide Hydrochloride Tablets Cover
Amazon Basic Care Loperamide Hydrochloride Tablets, 2 mg, Anti-Diarrheal, 24 Count (Pack of 1) (Packaging may vary)

Amazon Basic Care Loperamide Hydrochloride Tablets contain 2 mg of Loperamide Hydrochloride, an anti-diarrheal medicine that controls symptoms of diarrhea, including Travelers' Diarrhea. These capsule-shaped tablets can be used by adults and children age 6 years and older.

What We Like
Very effective results
Affordable price
Easy-to-swallow tablets
Convenient blister packaging
What We Don't Like
Sharp blister pack edges
Pills taste bitter if chewed
#TOP 2

Imodium A-D Softgels for Diarrhea Relief

Imodium A D Anti Diarrheal Medicine
Imodium A-D Softgels for Diarrhea Relief Cover
Imodium A-D Fast-Acting Anti-Diarrheal Softgels, Loperamide HCl 2 mg, Travel Essential Diarrhea Relief Medicine for Adults, 24 Count, Anti Diarrhea Pills, Ages 12+, Easy to Swallow

Imodium A-D Softgels are a fast and effective way to control diarrhea symptoms with just one dose. Its proven formula works with your body to slow down your system and restore its natural rhythm, suitable for adults and children 12 years and older. It is the #1 doctor-recommended anti-diarrheal brand for symptom relief and control, working faster than prescription medication. The softgels come in a convenient tear-away packaging, making them easily portable and ideal for on-the-go relief anytime, anywhere.

What We Like
Easy to swallow
Fast relief
Individually wrapped
Highly effective
Convenient for travel
What We Don't Like
Challenging blister packaging
#TOP 3

IBgard Peppermint Oil Gut Health Capsules

IM484
Green
IBgard Peppermint Oil Gut Health Capsules Cover
IBgard Gut Health Supplement, Peppermint Oil Capsules for Abdominal Comfort, 48 Capsules

The IBgard Peppermint Oil Capsules are designed to support your digestive health daily. They help ease common gut issues such as cramping, diarrhea, constipation, bloating, and gas, making you feel more comfortable throughout the day. Using ultrapure peppermint oil, these capsules promote a balanced gut environment and help your digestive system relax, which can improve how your body absorbs nutrients. Recommended by gastroenterologists, this supplement starts working quickly—often within 24 hours—so you can find relief fast. With patented technology, the peppermint oil is delivered exactly where your gut needs it most, giving you targeted support for abdominal comfort.

What We Like
Immediate IBS symptom relief
Natural peppermint oil formula
Gentle on stomach
Reduces cramping and discomfort
Easy-to-take capsules
What We Don't Like
Peppermint aftertaste
Pricey for some users
#TOP 4

Pepto Bismol Chewable Tablets 30 ct

03977BX
Pepto Bismol Chewable Tablets 30 ct Cover
Pepto Bismol Chewable Tablets, Upset Stomach Relief, Nausea Relief, Heartburn Relief, Indigestion Relief, Anti Diarrhea Medication for Adults - 5 Symptom Relief, 30 ct

Pepto Bismol Chewables offer quick relief when your stomach starts feeling off. This product helps ease nausea, heartburn, indigestion, and general upset stomach, so you can get back to your day without discomfort. It uses one strong ingredient that targets multiple stomach issues at once, making it a reliable choice when you’re facing more than one symptom. Plus, it soothes your stomach lining by coating it, which helps calm irritation and makes you feel better faster. The chewable mint tablets are easy to take anywhere, giving you convenient relief whenever you need it.

What We Like
Fast-acting relief
Chewable convenience
Multi-symptom effectiveness
Portable for travel
No water needed
What We Don't Like
Chalky taste
Wrapper can be tricky
#TOP 5

Imodium Multi-Symptom Relief Caplets

Sex Toys Dildo
Sex Toys Dildo
Imodium Multi-Symptom Relief Caplets Cover
Imodium Multi-Symptom Relief Caplets with Loperamide Hydrochloride & Simethicone, Anti-Diarrheal Medicine for Treatment of Diarrhea, Gas, Bloating, Cramps & Pressure, Easier to Open, 24 ct

Imodium Multi-Symptom Relief Caplets provide 24 count of effective relief against diarrhea and its related symptoms. It contains loperamide HCl and simethicone to slow down the system and restore natural balance, reducing bloating, gas, pressure, and cramps. This branded medication is suitable for adults and children over 12 years old and can be used both at home and on-the-go.

What We Like
Fast-acting relief
Easy-to-swallow tablets
Travel-friendly packaging
Gentle on stomach
Doctor-recommended
What We Don't Like
Packaging sometimes hard to open
Pills may split when pressed out
#TOP 6

Imodium A-D Diarrhea Relief Caplets

300450295323
Imodium A-D Diarrhea Relief Caplets Cover
Imodium A-D Diarrhea Relief Caplets with Loperamide HCl, Anti-Diarrheal Medicine to Help Control Symptoms of Diarrhea Due to Acute, Traveler's Diarrhea, HSA/FSA Eligible, 24 ct

Imodium A-D Diarrhea Relief Caplets with Loperamide HCl is an anti-diarrheal medicine that can help control and treat diarrhea symptoms for effective relief. Its proven formula works with your body to slow down your system and restore its natural rhythm and balance, allowing you to continue doing the things you love. Each caplet contains 2 milligrams of loperamide hydrochloride to help control symptoms of diarrhea due to acute, active and Traveler's diarrhea. The caplets are available in convenient tear-away packaging, suitable for use both at home and on-the-go, and are ideal for adults and children ages 6 and up.

What We Like
Fast-acting diarrhea relief
Gentle on stomach
Trusted, reliable brand
Convenient for travel
Effective for IBS symptoms
What We Don't Like
Difficult packaging
#TOP 7

Pepto Bismol Liquid

1299292831
Pepto Bismol Liquid Cover
Pepto Bismol Liquid, Upset Stomach Relief, Nausea Relief, Heartburn Relief, Indigestion Relief, Anti Diarrhea Medication for Adults - 5 Symptom Fast Relief, 2x12 oz (Packaging May Vary)

Pepto Bismol Relief is a trusted brand that has been providing fast relief for upset stomachs for over 100 years. Its coating action helps to calm the stomach and soothe the digestive system, effectively relieving symptoms such as nausea, heartburn, indigestion, upset stomach, and diarrhea. With Pepto Bismol Relief, you can experience relief from these uncomfortable symptoms, allowing you to get back to your day without interruption. As the #1 pharmacist recommended brand for upset stomachs, you can trust Pepto Bismol Relief to provide high-quality relief that you can count on.

What We Like
Fast-acting relief
Reliable for upset stomach
Convenient availability
Pleasant flavor
Easy dosing
What We Don't Like
Unremarkable taste
#TOP 8

Pepto Bismol Liquicaps, Multi-Symptom Relief of Upset Stomach, 48 Liquicaps

Pepto Bismol Liquicaps, Multi-Symptom Relief of Upset Stomach, 48 Liquicaps Cover
Pepto Bismol Liquicaps, Upset Stomach Relief, Nausea Relief, Heartburn Relief, Indigestion Relief, Anti Diarrhea Medication for Adults - 5 Symptom Fast Relief, No Flavor, 48 ct

Pepto Bismol Liquicaps provide fast and effective multi-symptom relief from nausea, heartburn, indigestion, upset stomach, and diarrhea. Its coating action calms and soothes your stomach and digestive tract.Pepto Bismol Liquicaps are a convenient way to get on-the-go relief from your upset stomach symptoms. As a part of the P&G family, Pepto Bismol has high quality standards for all our products.

What We Like
Fast and effective multi-symptom relief
Convenient for on-the-go relief
Calms and soothes stomach and digestive tract
High quality standards as a part of the P&G family
#TOP 9

A+Health Loperamide Hcl 2 Mg Softgels

Amazon Basic Care
LOP24
A+Health Loperamide Hcl 2 Mg Softgels Cover
Amazon Basic Care Loperamide Hcl 2 Mg Softgels, Anti-Diarrheal, 24 Count (Pack of 1)

A+Health Loperamide Softgels are an effective solution for controlling diarrhea. These softgels contain Loperamide Hcl 2mg, which is the active ingredient found in Imodium A-D. They are specially designed to help control the symptoms of diarrhea, including Travelers' Diarrhea. Made in the USA using ingredients from various countries, these liquid-filled capsules are easy to swallow, making them suitable for people who have difficulty swallowing. The softgels are suitable for adults and children 12 years and older, with each pack containing 24 softgels. The directions recommend taking 2 softgels after the first loose stool, followed by 1 softgel after each subsequent loose stool, with a maximum of 4 softgels in 24 hours. Stay hydrated by drinking plenty of clear fluids along with the softgels to alleviate diarrhea effectively.

What We Like
Fast-acting gel capsules
Affordable price
Works like name brand
Easy to swallow
Effective for stomach issues
What We Don't Like
Foil wrapper can be tricky
#TOP 10

Pepto Bismol Chewable Tablets

Pepto Bismol Chewable Tablets Cover
Pepto Bismol Chewable Tablets, Upset Stomach Relief, Nausea Relief, Heartburn Relief, Indigestion Relief, Anti Diarrhea Medication for Adults - 5 Symptom Relief, 90 Chewable Tablets (3x30 ct)

Pepto Bismol Chewable Tablets, also known as Pepto Bismol Chewables, are a fast and effective solution for multiple stomach-related symptoms. Whether you're dealing with nausea, heartburn, indigestion, upset stomach, or diarrhea, these chewable tablets provide quick relief. Recommended by pharmacists as the number one brand for upset stomachs, Pepto Bismol Chewables calm and soothe your stomach while providing relief for a range of digestive issues. The convenient chewable form allows for on-the-go relief, making it easy to manage your upset stomach symptoms wherever you are. With high-quality standards as part of the P&G family, Pepto Bismol Chewables are a reliable choice for anyone seeking fast and effective relief.

What We Like
Fast relief
Travel friendly
Great value
Convenient chewable form
Effective for multiple symptoms
What We Don't Like
Taste not for everyone
Rare packaging issues
Buying Guide Image

Frequently Asked Questions (FAQs)

1. What is the best medication for diarrhea?

Two types of meds relieve diarrhea in different ways: Loperamide (Imodium) slows the movement of food through your intestines, which lets your body absorb more liquid. Bismuth subsalicylate (Kaopectate, Pepto-Bismol) balances out how fluid moves through your digestive tract.

2. What are the most common Antidiarrheals?

Loperamide is the most commonly used antidiarrheal and has been shown to decrease fecal urgency, borborygmi, and diarrhea. Other agents commonly used are cholestyramine, which is a resin that binds bile acids, and ondansetron,46 which is a serotonin receptor antagonist.

3. Is Pepto or Imodium better for diarrhea?

All in all, Imodium A-D and Pepto-Bismol are both safe and effective over-the-counter treatments for diarrhea in most people. A few notable differences may affect which drug you choose. For example: Pepto-Bismol can treat several other related symptoms, such as heartburn, nausea, and indigestion.

Editor's Notes

During our antidiarrheal medication research, we found 26 antidiarrheal medication products and shortlisted 10 quality products. We collected and analyzed 590,158 customer reviews through our big data system to write the antidiarrheal medications list. We found that most customers choose antidiarrheal medications with an average price of $11.27.

The antidiarrheal medications are available for purchase. We have researched hundreds of brands and picked the top brands of antidiarrheal medications, including Imodium, IBgard, Pepto Bismol. The seller of top 1 product has received honest feedback from 384 consumers with an average rating of 4.7.

Written by
Bonnie Salem Avatar

Bonnie Salem is a stay-at-home mother with two-year-old twins and has spent almost half of her life surrounded by baby products. As a mother and a professional copywriter, she has an insightful and unique eye for researching products suitable for infants. Bonnie Salem is an expert in health and nutrition who lives with her family in New Jersey. She has over 15 years of working experience in an institute of medicine after graduating from the University of Toronto. She is highly interested in personal health and wellness.

Antidiarrheal Medications Comparison Table

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#TOP10
Brand Amazon Basic Care Imodium IBgard Pepto Bismol Imodium Imodium Pepto Bismol Pepto Bismol Amazon Basic Care Pepto Bismol
Product Benefits Anti-Diarrhea, Gluten Free Anti-Diarrhea Constipation control Digestive Relief Anti-Diarrhea, Gas Relief 24-count package of Imodium A-D Caplets with loperamide HCl to help control and treat diarrhea symptoms for effective relief Digestive Health, Heart Health, Nausea Relief, Stomach Pain Relief, anti - Digestive Health Relief From Nausea
Item dimensions L x W x H 1.13 x 3.13 x 3.5 inches 3.56 x 1.38 x 3.31 inches 1.81 x 3.07 x 5.11 inches 2.6 x 0.91 x 3.86 inches 1.5 x 3.84 x 3.15 inches 1.38 x 3.31 x 3.56 inches 2.63 x 5.25 x 6.88 inches - 3.88 x 3.28 x 0.88 inches -
Specific Uses For Product Diarrhea Diarrhea - Diarrhea, Digestion, Nausea Bloating, Diarrhea, Gas Relief Diarrhea Diarrhea, Heartburn, Indigestion, Nausea, Stomach Upset - Diarrhea Nausea
Item Weight - - - 1.4 Ounces 0.04 Kilograms - 1.6 Pounds - 0.04 Pounds 4.66 ounces
FTB Score
ftb score rating icon 9.8
ftb score rating icon 9.7
ftb score rating icon 9.5
ftb score rating icon 9.4
ftb score rating icon 9.4
ftb score rating icon 9.2
ftb score rating icon 9.1
ftb score rating icon 9.1
ftb score rating icon 8.9
ftb score rating icon 8.9
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