Best Joint & Muscle Pain Relief Medications of 2025

"I've tried many other pain patches, but these are truly excellent. I experience shoulder pain occasionally, and after applying a patch at night, I wake up without any pain. The medicinal smell is strong, but they heat up and start working almost immediately. I don’t buy anything else!"

"My orthopedic PA recommended the SalonPas cream for my leg pain, and it worked well. When I discovered the patches, I thought it was an excellent decision. I use them for my knee and shoulder, and I no longer wake up at night due to pain. I did give it a four-star rating because sometimes the patches don’t stick well."

"I work in an office, and my piriformis syndrome and carpal tunnel issues have been really bad. I've tried many patches that helped, but none worked as well as these. I typically use three on my hip and two on my wrist, and I experience minimal to no pain. The fact that 60 patches come in a box is a huge plus for me!"

"I started taking this product just two days ago, and I’m amazed at how much better my joints feel. I’m truly a believer!"

"I've been on my second month of the four capsules a day. They’re easy to take with no aftertaste. I've felt some relief from inflammation and plan to continue this routine."

"I've been taking Omega XL for a few months now. My lower back pain isn’t completely gone, but it’s definitely less than before. The small capsules are easy to swallow, and there's no medicinal taste."

"I suffer from chronic back pain and have tried many brands. This one works great, offering more value for the price. Yes, it has a slight menthol smell, but it's not overwhelming. It stays in place during the day and night, making it a great size for my shoulder or back."

"My mom has delicate skin, and these patches are fantastic. They stick better than the expensive brands and don't damage her skin when replaced. I cut each patch in half for her shoulders, and despite being very sticky, they stay put without the edges rolling up. I'm really pleased with the value!"

"I had some knee issues and found these patches to be effective. They provide pain relief throughout the night, and I can even split one patch for both knees. They are easy to separate and truly help me sleep better!"

"I've found these patches to be incredibly effective for my lower back and hip pain! The patches stay securely on my skin, and they really provide the extra help I need for pain relief. Great value for the money!"

"Using these patches, I've experienced significant pain relief. They adhere better than most patches I've tried, which is a huge advantage. However, I do find the scent to be a bit overpowering."

"I've been a long-time user of this brand and I must say, the quality is impressive. This time, coming from Japan, they feel even better. I'm really happy with this product!"

"I’ve used this cream for a week and it’s nearly eliminated my foot pain! After two surgeries, I’ve struggled with pain, but this has helped tremendously!"

"Although it's not a miracle cure, this product makes me feel a little better and it doesn’t have an off-putting smell."

"Penetrex has been amazing for my chronic elbow pain. After two years of trying various treatments, I've finally started to feel like I'm healing after only two weeks of use!"

"This product was a lifesaver for me! I pinched a nerve in my shoulder, and this gem was the only thing that offered me relief and allowed me to sleep. I highly recommend it!"

"I use this for my daughter's growing pains. She loves the cooling/heating sensation, as it feels like the medicine is working quickly. It's genuinely effective and has good durability."

"When I first opened it, I was surprised by how cold it was. My son, who has a bad back, said it works excellently during his long hours as a truck driver. There's also no irritation to the skin, which is a plus!"

"I've been using this product for years, and it consistently delivers results. I can't imagine my routine without it!"

"For me, this joint health supplement is the only one that truly works. It has made a noticeable difference."

"After trying various options, I found this one that almost eliminated my knee pain within weeks. I take one in the morning and one at night, and it really helps!"

“I bought Theraworx Relief for muscle cramps and leg soreness, and it definitely works as advertised. It provides quick relief for muscle spasms and soreness, especially after workouts or long days. However, the strong odor is hard to ignore. If you're sensitive to smells, this might be a dealbreaker, but if you can get past it, the relief it offers is definitely worth it.”

“I have used this product for years. If I exercise or drink coffee, I am prone to leg or hand cramps, especially at two or three in the morning. I rub this quality foam on my cramping legs. It's so easy to apply, and very effective in stopping the cramps immediately!”

“I've used this for a while, and it does work, but I have always used it sparingly because it contains parabens. I was excited to see the product image shows an ingredients list that no longer includes parabens. When I received the product, the ingredient list is different than the product picture shows, and it still contains parabens.”

"I was initially skeptical, but desperate enough to try these. They not only stop my leg cramps, but they work quickly!"

"I love everything about this product! I plan to use it for life. It works wonders for me, though I can't promise the same for others."

"These pills are a game-changer! I always keep some with me and another container under my pillow. They're lifesavers that truly deliver results!"

"This cream cracks me up! I’ve been using it for about two months and it really helps with my knee pain. It doesn’t completely eliminate the pain or stiffness, but I find it worth it."

"My husband has struggled with knee pain and has tried many products. Unfortunately, this one wasn’t as effective as he hoped. It’s easy to apply and not greasy, but the slight relief we felt was mostly from just rubbing it in."

"I just received the cream and applied it because my knee is really hurting today. Within two minutes, I felt no relief, and after 30 minutes, my pain is still there. I’m not sure if this reaction is normal or if I'm allergic."