Best Arthritis Pain Relief Medications of 2025

"I was initially skeptical, but after applying it last night, almost all the pain in my hand was gone by morning. It’s truly amazing! My doctor confirmed its safety, and I'm thrilled it works. I'm especially grateful that Amazon offers a generic version at a much lower price."

"This product works wonders for my shoulder pain. I felt relief in just 5 minutes and enjoyed a pain-free day."

"I've used various topical pain relievers over the years, but this Amazon brand has caused me the least problems. It’s incredibly effective for pain that other products haven’t alleviated."

"I was skeptical at first and even gave up after a few days. But when I tried again, on day 4, I noticed a huge difference. I have almost no pain compared to the constant burning I felt. I would recommend this product 100%!"

"After doing extensive yard work, my right hand was in terrible shape. It was swollen and painful, making it impossible to do simple tasks. I ordered this topical out of desperation, and it arrived quickly. I was amazed that within 30 to 45 minutes, I could actually move my hand and do things without too much pain. The relief was wonderful, and I'm so happy with this purchase!"

"Voltaren is hands down the best arthritis cream I've ever used. I couldn’t resist the Amazon deal, so I bought one for myself and one for my brother!"

"I've used this product for years. It works the same and smells the same as the prescription. I'm relieved it's not $19 like the generic brand I used to buy."

"I need a complete knee replacement, but until then, I rely on this daily for stiffness. A heating pad followed by this cream keeps me pain-free for hours."

"This product was recommended by my doctor, and it works great! No prescription needed now. I even bought some for my sister."

"I've been using Voltran cream for years for my lower back pain, and it really works well for me. I keep it on subscription so I never run out."

"After I sprained my ankle on ice, I ordered Voltaren a few days later, and it worked wonderfully. It helped relieve my pain significantly as I recovered."

"This is the first product that actually brought relief to my bone-on-bone knees. Just a tiny bit, three times a day, and I've been able to walk and stand comfortably!"

"I used this once and it helped my pain in my legs and arms. I would recommend this."

"Applying it is easy. I prefer it over Bengay, and it lasts a long time."

"My orthopedic doctor suggested I try this gel for my knee pain. While it didn't work for me, it was worth a shot. I've heard many people say it helps them a lot."

"I've tried many creams for my severe back pain. This one works great, is not greasy or messy, and also lasts a long time."

"A doctor recommended this for my son’s sore feet. He worked as a valet and experienced a lot of pain. It worked well for him, so he suggested it for my sore hands, likely from too much time on the computer. I also bought it for my granddaughter, who has been struggling with her hands due to excessive phone use and her job as a barber. This cream has helped her too. It’s becoming a family staple for pain relief. While it's somewhat pricey, it's worth it. I use it as needed, and it lasts quite a while. I appreciate the travel size included. It does have an alcohol smell, but it’s lightweight and dries in a minute. There’s a bit of stickiness, but I just wet my fingertips. Overall, I'm very satisfied with this product and will keep purchasing it."

"I suffer from severe tendonitis in both elbows. After trying numerous topical gels and creams without any noticeable results, I found this product. It's on the pricey side, but it absolutely works wonders. I love that it’s a mostly clear gel that dries quickly, leaves no residue, and has a pleasant scent. I can't emphasize enough how effectively it reduced my elbow pain, even after the very first use."

"I’ve been doing extensive yard work and overexerted my right hand, leading to swollen joints and muscles. I was in so much pain that I couldn’t even straighten my fingers. I tried ice and heat, but nothing helped. Unable to take ibuprofen due to my medications, I ordered this topical solution out of desperation. It arrived quickly, and I tried it this morning. It took about 30 to 45 minutes to kick in, but I’m amazed that I can actually move my hand now. I can type, write, and open things with much less pain. It still hurts a bit, but the relief is incredible, and I can MOVE again. I’m very pleased with this purchase."

“I have psoriatic arthritis and apply creams daily for pain and stiffness. I usually use regular Arnica, but decided to try this one. I’m not completely certain if the devil's claw makes a difference, but it still works just as well as regular Arnica. If I don’t notice a difference, I might switch back to the cheaper option.”

“My mom used to buy CBD cream for pain, but it got too pricey. A friend suggested trying the Arnica cream, and we did. My mom finds it just as effective as the CBD cream. We’re now on our third tub!”

“This arnica roll-on and cream are fantastic! I have tendinitis in my shoulder, and I use this every night before bed. It truly works great!”

"At first, I was uncertain about this product, but it turned out to be fantastic! My husband and I have experienced great results. My back pain has significantly lessened, making my life much more manageable. I highly recommend it!"

"I absolutely love this cream! I apply it to my hands, knees, and any other areas that hurt. It starts working immediately without any heat or cooling effect or unpleasant smell. I'll definitely be ordering it again!"

"I was a bit skeptical since I couldn't feel it working, and there was no smell or sensation of heat or cold, but surprisingly, it really does relieve pain. It's quite effective!"

"I regularly use acetaminophen for headaches and discomfort, and it never fails. It’s always in my medicine cabinet, and I’m careful not to exceed the recommended dose due to liver concerns. This giant size is perfect for sharing with my sister, so I won’t run out of my go-to analgesic. I’ll provide an update on the extended release after more use."

"I’m a registered nurse, and I never buy brand name medications. The generic version works just as well and saves so much money. I recommend it to my colleagues too."

"At 75, I can’t use Advil, so I rely on acetaminophen. I’m mindful of the 650mg dosage and how often I take it, especially with other medications containing acetaminophen. It’s a good buy, and I will definitely purchase it again."

"When I first started using this cream, it was only available by prescription. I'm thrilled that I can now order it from Amazon, and the three-pack lasts me for months. The effectiveness, ease of use, and pain relief for my shoulder and arm pain are excellent, plus it has a very pleasant smell."

"This product is just like the branded arthritis cream, but at a much better price. The delivery was amazing, as I received it the same day I ordered. I have no idea how you manage that!"

"I appreciated being able to purchase this in bulk at a reasonable price. It not only saves me a trip to the store but also costs about 50% less than the typical retail price. I'm all for generic medicine!"