Best Hypoallergenic Pillowcases of 2025

The Amazon Basics Pillow Protector is a hypoallergenic pillowcase made of 100% cotton with a tight weave design that minimizes exposure to dust and other common allergens, while providing breathable and cool comfort. The zipper closure fully encloses the pillow, creating a clean tailored look. This pillow protector is easy to clean, as it is machine washable and tumble dry safe on low heat, making it a convenient addition to any bedding set. Additionally, it is certified by Made in Green by OEKO-TEX, which ensures that textiles meet high safety and environmental standards. With dimensions of 21 x 27 inches, this pillowcase is suitable for standard size pillows.

Experience the incredible comfort of the Bare Home Pillowcase Set. Made with premium quality and double brushed microfiber, these pillowcases are exceptionally soft and durable. The unique Hydro-Brush process ensures long-lasting softness, making them the perfect companion for your pillow. Not only are they stain, fade, and wrinkle resistant, but they are also certified to meet high safety and environmental standards. With a standard size of 20" x 30", these pillowcases are easy to care for and can be machine washed and tumble dried. Plus, with Bare Home's 30-night guarantee, you can rest assured that if you don't love them, you can send them back. Upgrade your bedding with the Bare Home Pillowcase Set and enjoy a luxurious and comfortable sleep every night.

Arkwright Microfiber Pillowcases are the perfect bedding essentials for hosts of hotels, motels, rental properties, or even large families. Made from technologically advanced microfiber, these pillowcases are soft, lightweight, and durable. The breathable fabric ensures a comfortable sleeping experience, while the wrinkle-resistant and quick-drying properties make them easy to maintain. The pristine white color stays bright and fresh with simple care instructions. With a long lifespan and easy-care washing, these pillowcases are a cost-effective choice. Stock up on Arkwright Microfiber Pillowcases and enjoy the convenience of bulk buying while providing your guests or family members with a comfortable and luxurious sleeping environment.

HOMTEC Standard Pillowcases are crafted from 100% natural cotton with a 200-thread-count percale weave construction. These breathable and soft pillowcases are perfect for a restful night's sleep. The open type closure makes it easy to put in or take out the pillow. With a size of 20” x 30”, these pillowcases are suitable for standard or queen size pillows. The HOMTEC Standard Pillowcases are BSCI and OEKO-TEX certified, ensuring high safety and environmental standards. They are also easy to care for with machine wash and tumble dry. The high-quality cotton fabric becomes softer with every wash. With a full 5-year warranty and guarantee, these pillowcases make great gift ideas for various occasions.

The WishSmile Cooling Pillowcases are designed for those who struggle with heat during sleep. The fabric offers an instant cool sensation, perfect for hot sleepers, helping to regulate body temperature and minimize night sweats. You’ll also enjoy the luxurious softness of the fabric, which feels like silk against your skin. Additionally, these pillowcases come with an envelope closure that prevents hair tangling and keeps the pillow securely in place. They are easy to care for too, as they are machine washable and dry-friendly, ensuring convenience for your busy lifestyle.

The Warmstar Pillow Cases offer a blend of comfort and safety for your sleep. Made from 100% organic cotton, these pillowcases are soft and silky, providing a luxurious feel against your skin. Their breathable fabric helps regulate your body temperature throughout the night, ensuring a comfortable sleep experience. Additionally, these hypoallergenic pillowcases are perfect for those with allergies or sensitive skin, as they minimize exposure to dust and allergens. With durable construction and an envelope design, they keep your pillows securely in place while adding a touch of elegance to your bedding.

The Arkwright Pillow Cases are designed for both comfort and convenience, making them ideal for hospitality use. The unique blend of 55% cotton and 45% polyester ensures durability while remaining soft against your skin. You’ll appreciate the color-coded hems and care labels that simplify laundry sorting, helping you quickly identify sheet sizes. These pillowcases come in a bulk pack, allowing you to save money while stocking up for vacation rentals or hotels. Plus, they are built to withstand repeated washing, so you can enjoy increased comfort with every cycle without sacrificing quality.

Experience the luxurious smoothness and beauty benefits of the Spasilk Satin Pillowcase. Made from 100% pure charmeuse satin, this hypoallergenic pillowcase is recommended by dermatologists for its ability to reduce hair breakage and minimize facial wrinkles. The satin surface helps your hair glide smoothly, preventing tangles and knots, while also dissipating static electricity and retaining moisture to prevent dryness. With its envelope style and flap closure, this white pillowcase stays in place all night long. Machine washable and breathable, it is perfect for those looking to enhance their hair and skin beauty. Choose from Queen size - 20” x 30”, Queen - 2 pack, or King - 20” x 40” for the perfect fit.

ZIMASILK 100% Mulberry Silk Pillowcase is the perfect sleep fabric that is clinically proven to be the fabric of choice for those who are skin-conscious. It's soft, smooth, and both sides are made of premium grade 6A silk with 600 thread count, making it the highest grade organic silk. It is hypoallergenic and best for sensitive skin or minimizing wrinkles, acne, hair loss, and bed head. It also has more than 35 colors available, perfect for gift-giving during Thanksgiving, Christmas, and New Year festivals. Experience the luxury of ZIMASILK for 180 days with its guarantee of quality and risk-free shopping.

The Arianaut Khaki Pillow Cases are designed for comfort and convenience. Made from 100% brushed microfiber, these pillowcases offer a soft, breathable surface that helps keep you cool and dry throughout the night. They are also hypoallergenic, making them a great choice for those with sensitivities. With a wrinkle and fade-resistant finish, these cases maintain their fresh look, ensuring your bed stays neat and inviting. The envelope closure design provides an easy way to protect your pillows without the worry of zippers, allowing for a peaceful sleep experience.