Best Hypoallergenic Pillowcases of 2026

The Bare Home Microfiber Pillowcases come in a set of two standard-sized cases, perfect for refreshing your bedroom look. Made with a special Hydro-Brush technique, these pillowcases offer a soft and durable feel, making your sleep more comfortable night after night. They are designed to resist stains, fading, and wrinkles, so you spend less time worrying about upkeep and more time relaxing. Plus, they meet strict safety and environmental standards, giving you peace of mind. Caring for them is easy too — just machine wash cold and tumble dry on low, saving you time and effort.

The Amazon Basics Pillow Protector is a hypoallergenic pillowcase made of 100% cotton with a tight weave design that minimizes exposure to dust and other common allergens, while providing breathable and cool comfort. The zipper closure fully encloses the pillow, creating a clean tailored look. This pillow protector is easy to clean, as it is machine washable and tumble dry safe on low heat, making it a convenient addition to any bedding set. Additionally, it is certified by Made in Green by OEKO-TEX, which ensures that textiles meet high safety and environmental standards. With dimensions of 21 x 27 inches, this pillowcase is suitable for standard size pillows.

Protect your pillows from dust and allergens while enjoying breathable and cool comfort with the Amazon Basics 100% Cotton Hypoallergenic Pillow Protector. The vinyl-free pillowcase is designed with a tight weave to minimize exposure to common allergens. The zipper closure fully encloses the pillow and creates a clean tailored look. The machine-washable pillow protector is easy to clean and maintain. Measuring 21 by 31 inches, this pillowcase is suitable for both queen and standard size pillows. Made in Green by OEKO-TEX, this pillow protector meets high safety and environmental standards.

HOMTEC Standard Pillowcases are crafted from 100% natural cotton with a 200-thread-count percale weave construction. These breathable and soft pillowcases are perfect for a restful night's sleep. The open type closure makes it easy to put in or take out the pillow. With a size of 20” x 30”, these pillowcases are suitable for standard or queen size pillows. The HOMTEC Standard Pillowcases are BSCI and OEKO-TEX certified, ensuring high safety and environmental standards. They are also easy to care for with machine wash and tumble dry. The high-quality cotton fabric becomes softer with every wash. With a full 5-year warranty and guarantee, these pillowcases make great gift ideas for various occasions.

The Amazon Basics Pillow Protector is a hypoallergenic pillowcase designed with 100% cotton and a tight weave to minimize exposure to dust and allergens while providing breathability and cool comfort. The zipper closure fully encloses the pillow, creating a clean tailored look and making it easy to remove and wash. Suitable for body pillows, this pillowcase measures 21 by 55 inches and is machine washable. It is made in Green by OEKO-TEX, an independent certification system that ensures textiles meet high safety and environmental standards. Protect your pillow from allergens and ensure a comfortable sleep with the Amazon Basics Pillow Protector.

ZIMASILK 100% Mulberry Silk Pillowcase is the perfect sleep fabric that is clinically proven to be the fabric of choice for those who are skin-conscious. It's soft, smooth, and both sides are made of premium grade 6A silk with 600 thread count, making it the highest grade organic silk. It is hypoallergenic and best for sensitive skin or minimizing wrinkles, acne, hair loss, and bed head. It also has more than 35 colors available, perfect for gift-giving during Thanksgiving, Christmas, and New Year festivals. Experience the luxury of ZIMASILK for 180 days with its guarantee of quality and risk-free shopping.

The Beckham Cooling Pillowcases are designed to keep you comfortable all night long. Made from soft, breathable fabric, they allow air to flow freely, helping you stay cool even if you tend to get hot while sleeping. The smooth surface reduces friction, which means less bedhead and fewer skin creases, making it gentle on sensitive skin too. With an easy-to-use envelope closure, these pillowcases securely hold your pillows without the hassle of buttons or zippers. Plus, they match well with other bedding items to create a fresh, hotel-like look in your bedroom. Enjoy a cooler, more restful sleep every night.

The Organic Cotton Mart Pillowcases offer a natural and comfortable sleep experience with their 100% organic cotton fabric that helps regulate your body temperature, keeping you cool through the night. You’ll appreciate the hypoallergenic nature of these pillowcases, making them gentle on sensitive skin and perfect for a healthy rest. They are made following strict organic farming standards, so you avoid exposure to harmful chemicals or dyes, plus you support eco-friendly and fair trade practices. These pillowcases are also durable and easy to care for, as they can be machine-washed and dried without losing quality. Enjoy a cozy and sustainable bedding upgrade with these breathable and long-lasting pillowcases.

The Nestl Soft Pillowcases offer a truly comfortable sleep with their high-quality double brushed microfiber fabric, which feels soft and gentle against your skin. These pillowcases are designed to be lightweight and breathable, helping you stay cool throughout the night. The queen/standard size fits most pillows and features a neat back envelope closure, giving your bed a polished look. Plus, they are easy to care for—simply machine wash in cold water and tumble dry on low without worrying about fading, shrinking, or wrinkles. With these pillowcases, you get both comfort and convenience to improve your sleep experience.

The ZPECC White Pillowcases offer a convenient set of four standard-sized covers that fit 20 by 26-inch pillows perfectly. Made from OEKO-TEX STANDARD 100 certified microfiber fabric, these pillowcases are gentle on your skin and safe for allergy sufferers, ensuring a comfortable and breathable sleeping experience. Thanks to precise automated stitching, each pillowcase maintains consistent sizing and quality with a practical envelope closure for easy pillow insertion and removal. These versatile cases also serve as a great base for DIY projects like painting or embroidery, letting you personalize your bedroom decor effortlessly.