Best Hypoallergenic Bed Pillow Protectors of 2026

Denise Buck Avatar
Denise Buck
Last Updated: Jan 13, 2026

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Hypoallergenic bed pillow protectors are a must-have for anyone who suffers from allergies or asthma. These protectors are designed to keep allergens such as dust mites, pollen, and pet dander from getting into your pillow, which can trigger allergic reactions and make it difficult to breathe. Made from high-quality materials, these protectors are soft, comfortable, and easy to clean. They are available in a range of sizes to fit any pillow, and are an affordable way to protect your health and get a good night's sleep. Whether you're looking for protection from allergens or simply want to keep your pillow clean and fresh, hypoallergenic bed pillow protectors are a smart choice.

At a Glance: Our Top Picks

Amazon Basics Pillow Protector Case - Body, White Cover #TOP 1
Amazon Basics Pillow Protector Case - Body, White
ftb score rating icon 9.9
SureGuard Pillow Protectors Cover #TOP 2
SureGuard Pillow Protectors
ftb score rating icon 9.8
Four Seasons Essentials Pillow Protectors Cover #TOP 3
Four Seasons Essentials Pillow Protectors
ftb score rating icon 9.6

Top 5 Hypoallergenic Bed Pillow Protectors

Amazon Basics Pillow Protector Case - Body, White

Amazon Basics
AB-ALE-PC-WHT-BD
White
Body Pillow
Amazon Basics Pillow Protector Case - Body, White Cover
Amazon Basics Body Pillow Pillowcase with Zipper, 100% Cotton Hypoallergenic, Pillow Protector, White (55 x 21 Inches), Pillows Not Included

The Amazon Basics Pillow Protector is a hypoallergenic pillowcase designed with 100% cotton and a tight weave to minimize exposure to dust and allergens while providing breathability and cool comfort. The zipper closure fully encloses the pillow, creating a clean tailored look and making it easy to remove and wash. Suitable for body pillows, this pillowcase measures 21 by 55 inches and is machine washable. It is made in Green by OEKO-TEX, an independent certification system that ensures textiles meet high safety and environmental standards. Protect your pillow from allergens and ensure a comfortable sleep with the Amazon Basics Pillow Protector.

What We Like
Soft cotton fabric
Secure zipper closure
Good allergen protection
Excellent fit
Easy to clean
#TOP 2

SureGuard Pillow Protectors

PILPRO-2SMS
White
Standard
SureGuard Pillow Protectors Cover
Set of 2 Standard Size SureGuard Pillow Protectors - 100% Waterproof, Bed Bug Proof, Hypoallergenic - Premium Zippered Cotton Covers - Smooth

SureGuard Pillow Covers are the perfect solution to protect your pillows and ensure a clean and fresh sleeping environment. These premium zippered cotton covers are 100% waterproof, providing total protection against perspiration, liquids, and stains. With their super fine zipper and Invisi-Zip technology, they are also bed bug proof, completely sealing off your pillow from these unwanted pests. The hypoallergenic feature blocks dust mites, mold, mildew, pollen, and pet dander, making it ideal for those with allergies. The soft and noiseless 100% cotton surface wicks away moisture, retaining the feel of your pillow. SureGuard Pillow Covers are also free from toxic chemicals, ensuring a safe and healthy sleep. Machine washable and dryer friendly, these standard size pillow covers come in a set of two. Independently lab tested and GREENGUARD Gold certified, they offer a 10-year quality guarantee, providing you with peace of mind.

What We Like
Soft fabric, especially after washing
Good zipper quality
Excellent pillow protection
Perfect fit for pillows
Quiet, no crinkling noise
#TOP 3

Four Seasons Essentials Pillow Protectors

FSE-PES-001
White
Standard
Four Seasons Essentials Pillow Protectors Cover
Standard Pillow Protectors (Set of 2) – Zippered Waterproof Pillow Covers Hypoallergenic Dust and Allergen Proof Pillowcase Encasement

The Four Seasons Essentials Standard Pillow Protectors Set is an essential addition to your bedding collection. The set includes 2 Standard Size Pillow Protectors measuring 21" (Width) x 27" (Length). The 100% waterproof pillow protectors have a polyurethane inner lining that blocks liquids and moisture to keep your pillow dry and protected. The stretchable, breathable fabric keeps contaminants out without compromising on comfort. The hypoallergenic cover helps you breathe easy by sealing out dust, pet hair, and other allergens. The zipper closure completely seals off the pillow, making it easy to use and maintain.

What We Like
Soft and quiet fabric
Waterproof and stain protection
Hypoallergenic and allergy relief
Sturdy zipper closure
Fits standard and queen pillows
#TOP 4

HOSPITOLOGY PRODUCTS Pillow Encasement

SDSP02S
White
HOSPITOLOGY PRODUCTS Pillow Encasement Cover
HOSPITOLOGY PRODUCTS Pillow Encasement- Zippered Bed Bug Dust Mite Proof Hypoallergenic - Sleep Defense System - Standard - Waterproof - Set of 2 - 20" H x 26" W

Protect your pillows with HOSPITOLOGY PRODUCTS Pillow Encasement - Set of 2 Standard Size (20” x 26”). Made of extra-soft polyester knit fabric, the encasement is cool, comfortable, and waterproof. It helps improve sleep quality by reducing common substances that can reach the sleeper and disrupt respiratory function. The encasement is machine washable and comes with a 5-Year Limited Manufacturer's Warranty.

What We Like
100% waterproof
Extra-soft polyester knit fabric
Breathable waterproof membrane won't retain heat
#TOP 5

National Allergy 100% Cotton Zippered Pillow Protectors 2 Pack

AMZ10001PK2
2 Pack
Standard (21x27)
National Allergy 100% Cotton Zippered Pillow Protectors 2 Pack Cover
National Allergy Premium 100% Cotton Zippered Pillow Protector - Standard Size - White - 2 Pack - 300 Thread Count - Hypoallergenic Bed Pillowcase with Zipper - Breathable Encasement Cover

The National Allergy Cotton Pillow Protectors offer advanced protection by fully encasing your pillows in breathable 100% cotton fabric, helping you sleep soundly. The unique zipper system keeps your pillow completely sealed, preventing dirt and allergens from getting inside. The tightly woven cotton fabric lets air circulate while blocking tiny particles, keeping you cool and comfortable all night. Plus, the soft, noiseless material ensures you won’t be disturbed by rustling noises as you move. These protectors provide a comfortable and secure barrier that helps maintain pillow freshness and hygiene for a better sleep experience.

What We Like
Breathable 100% cotton
Secure zipper closure
Tightly woven fabric
Noiseless material
Buying Guide Image

Frequently Asked Questions (FAQs)

1. What does a hypoallergenic pillow case do?

"Hypoallergenic pillowcases help with keeping the dust mites out of your pillow so that the inside of it is not full of dust mite feces, which is what we are allergic to," New York-based allergist Payel Gupta, MD, FAACI, tells Health.

2. Are pillow protectors worth it?

Pillow protectors help promote healthy sleep and contribute to a healthy sleeping environment in several ways. Moisture in your bedding can quickly lead to mold and mildew. A protector also stops dust mites and can also help prevent the spread of bed bugs.

Editor's Notes

During our hypoallergenic bed pillow protector research, we found 24 hypoallergenic bed pillow protector products and shortlisted 5 quality products. We collected and analyzed 421,910 customer reviews through our big data system to write the hypoallergenic bed pillow protectors list. We found that most customers choose hypoallergenic bed pillow protectors with an average price of $17.66.

The hypoallergenic bed pillow protectors are available for purchase. We have researched hundreds of brands and picked the top brands of hypoallergenic bed pillow protectors, including SureGuard Mattress Protectors, Four Seasons Essentials, HOSPITOLOGY PRODUCTS, National Allergy. The seller of top 1 product has received honest feedback from 384 consumers with an average rating of 4.7.

Written by
Denise Buck Avatar

Denise Buck is an excellent content writer. She has the ability to look for great deals on Home & Kitchen appliances and office products on the Internet for various customers, then she can write a complete buying guide to help you find products that fit your budget and the best bargains.