Best Hypoallergenic Bed Pillow Protectors of 2025

Denise Buck Avatar
Denise Buck
Last Updated: Jan 9, 2025

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Hypoallergenic bed pillow protectors are a must-have for anyone who suffers from allergies or asthma. These protectors are designed to keep allergens such as dust mites, pollen, and pet dander from getting into your pillow, which can trigger allergic reactions and make it difficult to breathe. Made from high-quality materials, these protectors are soft, comfortable, and easy to clean. They are available in a range of sizes to fit any pillow, and are an affordable way to protect your health and get a good night's sleep. Whether you're looking for protection from allergens or simply want to keep your pillow clean and fresh, hypoallergenic bed pillow protectors are a smart choice.

At a Glance: Our Top Picks

Four Seasons Essentials Pillow Protectors Cover #TOP 1
Four Seasons Essentials Pillow Protectors
ftb score rating icon 9.9
Set of 2 SureGuard Pillow Protectors - Waterproof, Bed Bug Proof, Hypoallergenic Cover #TOP 2
Set of 2 SureGuard Pillow Protectors - Waterproof, Bed Bug Proof, Hypoallergenic
ftb score rating icon 9.8
Set of 4 Standard Pillow Protectors Cover #TOP 3
Set of 4 Standard Pillow Protectors
ftb score rating icon 9.6

Top 10 Hypoallergenic Bed Pillow Protectors

#TOP 1

Four Seasons Essentials Pillow Protectors

FSE-PES-001
White
Standard
Four Seasons Essentials Pillow Protectors Cover
Standard Pillow Protectors (Set of 2) – Zippered Waterproof Pillow Covers Hypoallergenic Dust and Allergen Proof Pillowcase Encasement

The Four Seasons Essentials Standard Pillow Protectors Set is an essential addition to your bedding collection. The set includes 2 Standard Size Pillow Protectors measuring 21" (Width) x 27" (Length). The 100% waterproof pillow protectors have a polyurethane inner lining that blocks liquids and moisture to keep your pillow dry and protected. The stretchable, breathable fabric keeps contaminants out without compromising on comfort. The hypoallergenic cover helps you breathe easy by sealing out dust, pet hair, and other allergens. The zipper closure completely seals off the pillow, making it easy to use and maintain.

What We Like
100% waterproof pillow protector
Soft, breathable and completely noiseless
Hypoallergenic cover to keep allergens away
Easy to use and maintain with the zipper closure
#TOP 2

Set of 2 SureGuard Pillow Protectors - Waterproof, Bed Bug Proof, Hypoallergenic

PILPRO-2PKS
White
Standard
Set of 2 SureGuard Pillow Protectors - Waterproof, Bed Bug Proof, Hypoallergenic Cover
Set of 2 Standard Size SureGuard Pillow Protectors - 100% Waterproof, Bed Bug Proof, Hypoallergenic - Premium Zippered Cotton Terry Covers

The Set of 2 Standard Size SureGuard Pillow Protectors offers 100% waterproof protection against perspiration, saliva, liquids, and stains, making it a great choice for those with allergies or who suffer from nighttime sweating. It also effectively blocks bed bugs and common allergens such as dust mites, mold, pollen, and pet dander. The soft and noiseless 100% cotton terry surface wicks away moisture and retains the feel of your pillow. This product is machine washable and GREENGUARD Gold certified, ensuring that it meets strict chemical emissions standards.

What We Like
100% waterproof protection
Effective bed bug and allergen blocking
Soft and noiseless cotton terry surface
Machine washable
GREENGUARD Gold certified
#TOP 3

Set of 4 Standard Pillow Protectors

MES-PPST-4PK
White
Standard
Set of 4 Standard Pillow Protectors Cover
Standard Pillow Protectors (Set of 4) – Hypoallergenic Pillow Cover Waterproof Dust Allergen Proof Zippered Encasement

The Set includes 4 Standard Size Pillow Protectors measuring 21" x 27". The breathable and stretchable fabric ensures comfort by keeping liquids, contaminants, and allergens away from the pillow. It is completely noiseless and waterproof to prevent spills and accidents from getting to your pillow. The zippered protector is made of high-quality polyester and waterproof polyurethane that seals off the pillow completely.

What We Like
Comes in a set of 4
100% waterproof and noiseless
Keeps allergens and contaminants away from the pillow
#TOP 4

HOSPITOLOGY PRODUCTS Pillow Encasement

SDSP02S
Standard
HOSPITOLOGY PRODUCTS Pillow Encasement Cover
HOSPITOLOGY PRODUCTS Pillow Encasement- Zippered Bed Bug Dust Mite Proof Hypoallergenic - Sleep Defense System - Standard - Waterproof - Set of 2 - 20" H x 26" W

Protect your pillows with HOSPITOLOGY PRODUCTS Pillow Encasement - Set of 2 Standard Size (20” x 26”). Made of extra-soft polyester knit fabric, the encasement is cool, comfortable, and waterproof. It helps improve sleep quality by reducing common substances that can reach the sleeper and disrupt respiratory function. The encasement is machine washable and comes with a 5-Year Limited Manufacturer's Warranty.

What We Like
100% waterproof
Extra-soft polyester knit fabric
Breathable waterproof membrane won't retain heat

National Allergy Cotton Pillow Protector - Queen Size - White - 2 Pack

10002PK2
2 Pack
Queen (21x31)
National Allergy Cotton Pillow Protector - Queen Size - White - 2 Pack Cover
National Allergy Premium 100% Cotton Zippered Pillow Protector - Queen Size - White - 2 Pack - 300 Thread Count - Hypoallergenic Bed Pillowcase with Zipper - Breathable Encasement Cover

The National Allergy Premium 100% Cotton Zippered Pillow Protector is a set of two pillowcases recommended by doctors. Made of 100% breathable cotton, the tight weave ensures only air can get through. The zipper system has an auto-locking function to ensure the pillow stays protected, while the added barrier creates a fabric shield under the zipper closure. The pillow protector is durable, quiet, and machine washable, making it easy to clean and maintain.

What We Like
Recommended by doctors
Tight weave ensures breathability and protection
Auto-locking zipper and added barrier provide extra protection
Durable, quiet, and machine washable
#TOP 6

Guardmax Waterproof Pillow Protector Standard Size

Guardmax
White
Guardmax Waterproof Pillow Protector Standard Size Cover
Guardmax Waterproof Pillow Protector Standard Size - Zippered Bed Bug Pillow Protector 6 Pack - Hypoallergenic Pillow Case Cover Protects from BedBug, Dust Mite, and Liquid Spills - (20 X 26)

Guardmax Pillow Protector is a waterproof, bed bug-resistant, hypoallergenic pillowcase cover that safeguards against liquid spills and stains. The zipper enclosure, utilizing Guardmax Patented Technology, effectively seals out bed bugs. Its hypoallergenic design protects against dust mites and allergens, promoting healthier skin contact. The patented zippered feature ensures no pests escape once zipped up. Enjoy a soft, comfortable, noiseless pillow encasement that is also wrinkle-free, making it easy to maintain and wash in the machine.

What We Like
Waterproof & Bed Bug-Resistant
Hypoallergenic & Zippered
Soft, Comfortable & Noiseless
#TOP 7

Waterproof Pillow Covers Standard Size (2 Pack)

FBA_COMINHKG110484
White
Standard
Waterproof Pillow Covers Standard Size (2 Pack) Cover
Waterproof Pillow Protector Standard (2-Pack) - Zippered, Hypoallergenic, Dust Mite & Bed Bug Proof, Allergy Pillow Covers

The Everlasting Comfort Premium Waterproof Pillow Covers Standard Size (2 Pack) are designed to protect your pillows against liquid threats and common irritants. Made with high-quality materials and a dual-layer protective membrane, these pillowcase protectors are wear and tear-resistant and prolong the life of your pillows. The breathable waterproof pillow covers keep you cool and comfortable and are noiseless for an uninterrupted sleep. Our full encasement pillow covers protect all sides of your pillows, keeping your sleeping environment safe and healthy.

What We Like
100% waterproof to shield against liquid threats
Hypoallergenic and resistant to common irritants
Breathable waterproof pillow covers keep you comfortable
Wear and tear-resistant to prolong the life of your pillows
Noiseless for an uninterrupted sleep
#TOP 8

Right Choice Bedding Cotton Pillow Protectors with Zipper

Right Choice Bedding
White
Standard
Right Choice Bedding Cotton Pillow Protectors with Zipper Cover
Right Choice Bedding Cotton Pillow Protectors with Zipper - Hypoallergenic Pillow Covers, Zip Up Pillowcase Standard Size 20x26 (Set of 2)

Right Choice Pillow Protectors by Right Choice Bedding offer top-quality protection for your pillows. The 100% cotton fabric is soft and breathable, providing a comfortable sleep experience. The zippered design ensures full coverage, keeping your pillow secure. With a 200-thread count fabric, these protectors are durable and soft, enhancing your sleep quality. Say goodbye to noisy protectors and enjoy a quiet night's sleep.

What We Like
100% cotton fabric
Zippered for full coverage
200-thread count fabric
#TOP 9

CoolShields Waterproof Pillow Protector

White
Standard
CoolShields Waterproof Pillow Protector Cover
CoolShields Waterproof Pillow Protector Zippered (2 Pack) Standard, Hypoallergenic Pillow Cover for a Better Sleep, Premium Pillowcase Encasement

The CoolShields Pillow Protector offers a reliable solution for keeping your pillows clean and fresh. Its waterproof design features a special inner lining that prevents spills, sweat, and other liquids from seeping through, extending the life of your pillows. With hypoallergenic properties, you can rest easy knowing that the protector helps reduce allergens, making it ideal for sensitive sleepers. The noiseless and soft Tencel fabric enhances your comfort by absorbing noise from movement, ensuring you enjoy a peaceful night’s sleep. Plus, the durable zip and double-stitched seams provide added security, keeping your pillows well-protected.

What We Like
Waterproof protection from spills
Hypoallergenic for sensitive users
Noiseless, soft Tencel fabric
Durable zip and stitching
#TOP 10

AVARNO Waterproof Pillow Protectors (4 Pack)

AVARNO
White
Queen(20"X30")
AVARNO Waterproof Pillow Protectors (4 Pack) Cover
AVARNO 4 Pack Waterproof Pillow Protectors with Zipper Queen Size Zippered Pillow Case Protectors Hypoallergenic Bed Pillow Covers Encasement Smooth Downproof Feather Proof Machine Washable

The AVARNO Pillow Protectors provide excellent protection for your pillows, ensuring they stay in great condition. They are 100% waterproof, guarding against spills and sweat, which helps extend the life of your pillows. With a high-quality zipper, these protectors keep dust, hair, and stains out, providing a clean sleeping environment. If you have allergies, you’ll appreciate that these covers are hypoallergenic, featherproof, and downproof, making them ideal for sensitive individuals. This combination of features ensures your pillows remain fresh and protected, giving you peace of mind while you sleep.

What We Like
100% waterproof protection
High-quality zipper
Hypoallergenic design
Machine washable
Buying Guide Image

Frequently Asked Questions (FAQs)

1. What does a hypoallergenic pillow case do?

"Hypoallergenic pillowcases help with keeping the dust mites out of your pillow so that the inside of it is not full of dust mite feces, which is what we are allergic to," New York-based allergist Payel Gupta, MD, FAACI, tells Health.

2. Are pillow protectors worth it?

Pillow protectors help promote healthy sleep and contribute to a healthy sleeping environment in several ways. Moisture in your bedding can quickly lead to mold and mildew. A protector also stops dust mites and can also help prevent the spread of bed bugs.

Editor's Notes

During our hypoallergenic bed pillow protector research, we found 24 hypoallergenic bed pillow protector products and shortlisted 10 quality products. We collected and analyzed 243,720 customer reviews through our big data system to write the hypoallergenic bed pillow protectors list. We found that most customers choose hypoallergenic bed pillow protectors with an average price of $16.86.

The hypoallergenic bed pillow protectors are available for purchase. We have researched hundreds of brands and picked the top brands of hypoallergenic bed pillow protectors, including Four Seasons Essentials, SureGuard Mattress Protectors, HOSPITOLOGY PRODUCTS, National Allergy, Guardmax. The seller of top 1 product has received honest feedback from 1,117 consumers with an average rating of 4.9.

Written by
Denise Buck Avatar

Denise Buck is an excellent content writer. She has the ability to look for great deals on Home & Kitchen appliances and office products on the Internet for various customers, then she can write a complete buying guide to help you find products that fit your budget and the best bargains.