Best Hypoallergenic Mattress Encasements of 2026

The HOSPITOLOGY PRODUCTS Mattress Encasement is a waterproof and hypoallergenic mattress cover that fits any Queen standard mattress depth from 12" to 18". The extra-soft polyester knit fabric is breathable and cool, with a waterproof membrane that won't trap heat. This encasement can help improve sleep quality by reducing common substances that can disrupt respiratory function. It is machine washable and comes with a 5-year limited warranty.

Protect your mattress with the Queen SureGuard Mattress Encasement. The six-sided premium mattress protector is 100% waterproof, bed bug proof, hypoallergenic, and blocks perspiration, bed wetting, liquids, and stains. It keeps your mattress clean and fresh, blocking dust, dirt, and dander on all sides. The super fine zipper with Invisi-Zip and SureSeal technology completely seals off the mattress from bed bugs. It is also soft and noiseless, made from 100% cotton terry top that wicks away moisture and retains the feel of your mattress. It is free from toxic chemicals and is machine washable and dryable. The encasement is GREENGUARD Gold certified and fits 13 to 16 inches deep.

The HOSPITOLOGY PRODUCTS Mattress Encasement is designed to fit any King-size mattress with a standard depth of 12" to 18". It features a 100% waterproof barrier on all six sides, ensuring protection against bed bugs and dust mites while also being lab-tested. The extra-soft polyester knit fabric is breathable and won't trap heat, helping to improve sleep by reducing respiratory disruption. It is machine washable and comes with a 5-year limited manufacturer's warranty.

The HOSPITOLOGY Mattress Encasement for Twin beds offers a zippered cover that fits mattresses with a depth of 6" to 8". Its 100% waterproof barrier on all sides is lab-tested to protect against bed bugs and dust mites. The extra-soft polyester fabric is breathable, ensuring a cool and comfortable sleep. By reducing common substances that can disrupt your respiratory function, this encasement can help improve your sleep quality. Additionally, it's machine washable for easy maintenance.

Protect your investment with this six-sided zippered encasement which is waterproof, noiseless, and durable. It is soft, stretchable, and breathable, making it easy to install and machine washable. Keep your mattress shielded from liquids, dust, pet hair, and contaminants with this hypoallergenic premium quality encasement. The Velcro zipper seal ensures that nothing gets in and the polyurethane inner lining blocks liquids and moisture from getting in.

Protect your investment with Four Seasons Essentials Queen Mattress Protector. It has a six-sided zippered encasement that completely covers your mattress, making it waterproof and hypoallergenic. The Velcro zipper seal ensures that nothing gets in, and it's easy to install. The stretchable, breathable fabric is soft and noiseless, providing comfort while keeping liquids and contaminants out. This durable and long-lasting mattress protector is machine washable for easy cleaning and lasting use.

The Four Seasons Split King Encasement offers a complete solution to protect your mattress from all sides with its zippered design, making it easy to secure and keep clean. Its waterproof layer shields your mattress from spills and accidents, ideal for homes with kids or pets. If you suffer from allergies, this hypoallergenic cover helps block dust, pet hair, and other irritants to improve your sleep quality. Plus, the fabric is soft, breathable, and quiet, so you stay comfortable without any noisy crinkling under your sheets. This encasement combines protection and comfort for a better night's rest.

The Four Seasons Mattress Protector offers complete protection for your twin mattress with a zipper that fully encloses all sides. This design keeps pets and allergens from damaging your mattress, giving you peace of mind. Its waterproof lining prevents spills and accidents from soaking through, keeping your mattress dry and clean. The hypoallergenic material helps reduce exposure to dust and other irritants, making it easier for you to breathe and sleep comfortably. Plus, the zipper makes it easy to put on and take off without struggle, saving you time and effort during setup.

The HOSPITOLOGY PRODUCTS Box Spring Encasement is a Queen size (60” x 80”) that fits box spring depths of 9"- 11". The stretchable 100% polyester knit fabric makes installation easy and the box spring cover is independently lab-tested. The encasement can help improve sleep by reducing common substances that can reach the sleeper and disrupt respiratory function. The product is also machine washable and dryable.

The SureGuard Twin Box Encasement offers complete protection for your box spring. Its waterproof design shields against spills and stains, keeping your bed fresh and dry. The advanced zipper system blocks bed bugs entirely, giving you peace of mind and a healthier sleep environment. This cover is also hypoallergenic, helping to keep dust mites, mold, pollen, and pet dander away, which is great if you suffer from allergies. Plus, its soft, stretchy fabric fits snugly without noise, making your bed comfortable and free from harsh chemicals. Overall, this cover keeps your box spring clean, safe, and comfortable with ease.