Best Hypoallergenic Mattress Encasements of 2025

The HOSPITOLOGY PRODUCTS Mattress Encasement is a waterproof and hypoallergenic mattress cover that fits any Queen standard mattress depth from 12" to 18". The extra-soft polyester knit fabric is breathable and cool, with a waterproof membrane that won't trap heat. This encasement can help improve sleep quality by reducing common substances that can disrupt respiratory function. It is machine washable and comes with a 5-year limited warranty.

Protect your mattress with the Queen SureGuard Mattress Encasement. The six-sided premium mattress protector is 100% waterproof, bed bug proof, hypoallergenic, and blocks perspiration, bed wetting, liquids, and stains. It keeps your mattress clean and fresh, blocking dust, dirt, and dander on all sides. The super fine zipper with Invisi-Zip and SureSeal technology completely seals off the mattress from bed bugs. It is also soft and noiseless, made from 100% cotton terry top that wicks away moisture and retains the feel of your mattress. It is free from toxic chemicals and is machine washable and dryable. The encasement is GREENGUARD Gold certified and fits 13 to 16 inches deep.

Protect your investment with Four Seasons Essentials Queen Mattress Protector. It has a six-sided zippered encasement that completely covers your mattress, making it waterproof and hypoallergenic. The Velcro zipper seal ensures that nothing gets in, and it's easy to install. The stretchable, breathable fabric is soft and noiseless, providing comfort while keeping liquids and contaminants out. This durable and long-lasting mattress protector is machine washable for easy cleaning and lasting use.

The SureGuard Box Spring Encasement is a premium zippered cover that provides six-sided protection for your box spring. It is 100% waterproof, offering protection against everyday liquids and stains. The super fine zipper with Invisi-Zip and SureSeal technology ensures that the encasement is bed bug proof, keeping your box spring safe from infestations. In addition, it is hypoallergenic, blocking dust mites, mold, mildew, pollen, and pet dander. The smooth stretch-knit surface of the encasement fits your box spring like a glove, providing a soft and noiseless sleeping experience. The SureGuard Box Spring Encasement is machine washable and dryer safe, making it easy to clean and maintain. With its 10-year quality guarantee and GREENGUARD Gold certification, this encasement offers both peace of mind and a fresh, clean sleeping environment.

The PlushDeluxe Premium Mattress Encasement is a six-sided waterproof bed cover that protects your mattress from dust, moisture, dirt, stains, and small critters. It has a snug and secure fit with a zippered closure hidden under a discreet flap. The mattress protector is made of terry fabric that stays noiseless even while you toss and turn. It is gentle on your skin, hypoallergenic, and made without dyes or additives that can cause itching or irritation.

The Zippered Queen Mattress Protector is a premium quality cover that completely encases your mattress on all sides, equipped with a Velcro zipper seal to ensure that nothing gets in. The 100% waterproof mattress protector has a polyurethane inner lining that blocks liquids and moisture from getting in, while the stretchable, breathable fabric keeps liquids and contaminants out without compromising comfort. With easy installation, machine washable for lasting use, and built to fit any Queen size mattress that is 8” to 11” deep, this mattress protector is an essential investment to protect your mattress from spills, dust, and pet hair.

The Twin XL Size Mattress Encasement is a six-sided zippered mattress protector that completely encases your mattress while providing waterproof and allergy relief. The hypoallergenic construction and impenetrable cover help you stay healthy and breathe easy while the stretchable, breathable fabric keeps liquids and allergens out without compromising comfort. The full zipper wraps all the way around the mattress and makes it easy to put on and take off. Made of high-quality polyester and polyurethane, this durable and long-lasting mattress encasement is machine washable for easy cleaning and lasting use.

Protect your investment with the Mattressentials Zippered Protector. This premium quality mattress encasement completely encases your mattress on all sides, keeping it safe from troublesome pets, spills, and accidents. The waterproof feature blocks liquids and moisture, ensuring your mattress stays dry and protected. Say goodbye to allergens and dust with the allergen relief feature, which shields you from irritating allergens and helps you breathe easy. The soft and noiseless fabric provides comfort without compromising on protection. Installing the Mattressentials Zippered Protector is a breeze with its easy-to-use full zipper. Sleep worry-free knowing that your mattress is shielded and protected.

This mattress protector has a six-sided zippered encasement with Velcro zipper seal, which completely encases your mattress, protects it from pets, spills, and allergens. The waterproof feature blocks liquids and moisture while the hypoallergenic construction shields you from irritating allergens. The soft and noiseless cotton terry surface provides comfort and breathability, and the full zipper makes it easy to install. The cover is machine washable and durable for long-lasting use.

The Guardmax Mattress Protector is designed to keep your mattress safe from spills and pests. Its 100% waterproof feature ensures that no liquid, whether it's a drink or an accident, can seep through, giving you peace of mind. Additionally, the bed bug proof design is a major advantage, as it effectively seals your mattress, preventing these unwanted guests from getting in. The zippered closure is made for durability, ensuring it won’t snag or break easily. Plus, you’ll appreciate the soft, breathable fabric that provides comfort while protecting your mattress.