Best Hypoallergenic Mattress Protectors of 2025

SafeRest Twin Mattress Protector is a waterproof, noiseless, and soft mattress protector made of cotton terry material that will not change the feel of your mattress. It protects your mattress against fluids and moisture, allowing you to sleep in silence with its breathable and wrinkle-free surface with membrane back coating. This bedding essential is perfect for kids, adults, and pets of all ages.

The Novted Mattress Protector offers advanced protection for your queen-sized bed. Infused with silver ions, it helps combat harmful substances and unpleasant odors, ensuring a healthier sleep environment. Its durable waterproof layer effectively shields against spills and stains, maintaining your mattress's cleanliness for years. Made from a soft bamboo rayon blend, this protector promotes a quiet and comfortable night's rest while dissipating heat. With a deep pocket design, it fits snugly on various mattress heights, making it easy to use and care for. Enjoy effortless maintenance with machine washability, simplifying your life while keeping your sleep space fresh.

The LUCID Premium Waterproof Mattress Protector is a must-have addition to your bed. This mattress protector is 100% waterproof, repelling all liquids including bodily fluids, perspiration, urine, and accidental spills. It provides machine washable protection, making it easy to clean and maintain. The hypoallergenic cotton terry surface and polyurethane backing ensure a comfortable and noiseless sleep while keeping allergy-causing dust and bacteria away from your mattress. The fitted sheet style with deep pockets is designed to fit mattresses up to 22 inches deep, providing a secure and snug fit. The ultra-thin design is breathable, quiet, and sleeps cool without altering the feel of your mattress. With the LUCID Premium Waterproof Mattress Protector, you can enjoy a clean, hygienic, and comfortable sleep environment for you and your loved ones.

Protect your mattress and sleep comfortably with the Linenspa Waterproof Mattress Protector. This fitted-sheet-style mattress protector is designed to keep your mattress surface safe and fresh. It features a 100% waterproof barrier that safeguards your mattress against liquids, spills, and accidents, preventing stains and messes. The soft and breathable brushed polyester finish ensures a quiet and cozy sleep experience without changing the feel of your mattress. The Linenspa Waterproof Mattress Protector is easy to care for, as it is machine washable and dryer safe. With a 10-year warranty, you can rest assured knowing that this mattress protector is backed by quality and durability.

The SureGuard Mattress Protector offers exceptional protection for your queen-sized mattress. With its 100% waterproof design, it shields against spills, sweat, and stains, ensuring your mattress stays fresh and clean. You’ll appreciate its soft, noiseless cotton surface that wicks away moisture, allowing you to enjoy the comfort of your mattress without any unwanted sounds. Additionally, this protector is durable and easy to care for—simply toss it in the washing machine when needed. With its fitted sheet style and stretchable skirt, it fits snugly on any mattress depth, providing peace of mind while you sleep.

BOSANE Premium 100% Waterproof Queen Mattress Protector is made with a 30% thicker waterproof layer than its competitors. It is hypoallergenic and safe, proven by the OEKO-TEX STANDARD 100 certificate, made of bamboo fiber and polyester, with no chemical bleach, vinyl or benzene. Featuring an advanced 3D air mesh design and breathable membrane, this quiet and breathable mattress protector is machine washable and tumble dry friendly. It also comes with a 5-year hassle-free after-sale service.

The Ohgeni Waterproof Mattress Protector offers exceptional protection and comfort for your sleep. With its advanced waterproof backing, you can rest easy knowing that spills or accidents won't damage your mattress. The soft top layer quickly absorbs moisture, keeping your sleeping surface dry and comfortable. Made from Rayon derived from bamboo, this protector ensures a quiet night's sleep without any crinkling sounds. Plus, it’s safe for everyone in your family, having passed rigorous safety tests. Enjoy a cool and restful sleep with its breathable design that promotes airflow.

The LINENSPA Mattress Protector offers comprehensive protection for your mattress. With its 100% waterproof design, you can rest easy knowing spills and accidents won't damage your mattress. The soft, breathable fabric ensures a quiet night's sleep without altering the feel of your mattress. Additionally, the protector covers all four sides, safeguarding against dust mites and allergens, keeping your sleep environment clean and healthy. Fitting mattresses up to 14 inches thick, it stays securely in place, adding convenience to your bedding routine.

The Four Seasons Mattress Protector offers comprehensive protection for your mattress. Its six-sided zippered encasement ensures that your mattress is completely covered, preventing pests and allergens from invading. You can rest easy knowing that it's waterproof, thanks to its special inner lining that blocks spills and accidents from seeping in. The soft and noiseless fabric keeps your sleep comfortable, so you won’t hear any crinkling noises while you rest. Plus, installation is a breeze with its full zipper design, making it simple to wrap your mattress securely.

The OhGeni Mattress Protector offers you complete waterproof protection, safeguarding your mattress from spills and stains. With its advanced dual-layer design, you can enjoy a plush terry cloth surface backed by durable TPU, ensuring your mattress remains dry and dust-free. This protector also enhances your comfort with its soft, breathable, and noiseless materials, promoting a peaceful night's sleep. Additionally, its deep-pocket design stretches to fit mattresses from 6 to 18 inches, giving you a secure and snug fit for full coverage.