Best Glucosamine Nutritional Supplement of 2025

Elisa Drew Avatar
Elisa Drew
Last Updated: Jan 16, 2025

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Glucosamine is a popular nutritional supplement that is commonly used to help alleviate joint pain and inflammation. It is a naturally occurring substance that is found in the fluid around joints, and it plays a vital role in maintaining joint health. Glucosamine supplements are often used by those with osteoarthritis, as it can help to reduce pain and stiffness in the joints. It is also believed to help improve joint mobility and flexibility, making it a popular choice for athletes and fitness enthusiasts. Glucosamine supplements come in various forms, including capsules, tablets, and powders, making it easy to incorporate into your daily routine.

At a Glance: Our Top Picks

Nature's Way Joint Movement Glucosamine Liquid Cover #TOP 1
Nature's Way Joint Movement Glucosamine Liquid
ftb score rating icon 9.8
Kirkland Signature Glucosamine with MSM, 375 Tablets Cover #TOP 2
Kirkland Signature Glucosamine with MSM, 375 Tablets
ftb score rating icon 9.7
Osteo Bi-Flex One Per Day Joint Health Supplement Cover #TOP 3
Osteo Bi-Flex One Per Day Joint Health Supplement
ftb score rating icon 9.5

Top 10 Glucosamine Nutritional Supplement

#TOP 1

Nature's Way Joint Movement Glucosamine Liquid

ST1394
Nature's Way Joint Movement Glucosamine Liquid Cover
Nature's Way Joint Movement Glucosamine Fast Absorbing Liquid, Ultra Strength, Supports Healthy Bones*, Chondroitin, and MSM with Vitamin D3, Berry Flavored, 16 Fl Oz (Packaging May Vary)

Nature's Way Joint Movement Glucosamine is a fast-absorbing liquid that supports healthy bones and muscle function. The formula includes 2,000 mg glucosamine, 1,200 mg chondroitin, MSM, and vitamin D3. It is formulated with MSM, a source of sulfur, glucosamine, a building block of cartilage tissue, and chondroitin, a component of connective tissue. The liquid is easy to take, and it comes in a delicious berry flavor. It is made with wholesome ingredients that are gluten-free, sugar-free, and shellfish-free. Nature's Way is a trusted health partner that offers essential vitamins, minerals, and supplements.

What We Like
Delicious berry flavor
Supports muscle function
Sugar-free option
Fast-absorbing formula
Effective for joint support
What We Don't Like
Flavor could be improved
Not vegetarian-friendly
#TOP 2

Kirkland Signature Glucosamine with MSM, 375 Tablets

249375
Kirkland Signature Glucosamine with MSM, 375 Tablets Cover
Kirkland Signature Glucosamine with MSM, 375 Tablets

The Kirkland Signature Extra Strength Glucosamine Extra Strength HCl with MSM tablets contain 1500mg of Glucosamine HCI and 1500mg of MSM to support healthy joints and cartilage. The supplement is USP Verified, ensuring its quality and purity. It falls under the category of Chondroitin Supplements.

What We Like
Improved mobility in pets
Effective alternative to NSAIDs
Economical option
Long-term user satisfaction
What We Don't Like
Large tablet size
Delivery time issues
#TOP 3

Osteo Bi-Flex One Per Day Joint Health Supplement

Osteo Bi-Flex One Per Day Joint Health Supplement Cover
Osteo Bi-Flex One Per Day, Glucosamine Joint Health Supplement with Vitamin D, Coated Tablets, 60 Count

Osteo Bi-Flex One Per Day Joint Health Supplement is a pharmacist-recommended joint care supplement that contains Joint Shield 5-LOXIN Advanced, a clinically studied herbal extract that can help improve joint comfort in just 7 days. Additionally, this supplement contains glucosamine chondroitin to nourish and strengthen joints for long-term health and Vitamin D for bone health and immune support.

What We Like
Joint pain relief
Improved stamina
Effective for muscle pain
Contains Glucosamine
What We Don't Like
Large pill size
Contains shellfish
#TOP 4

Joint Support Gummies with Glucosamine & Vitamin E - 120 Gummies

NNJointGummies
Joint Support Gummies with Glucosamine & Vitamin E - 120 Gummies Cover
Joint Support Gummies Glucosamine Plus Vitamin E - Nature's Joint Support Supplement for Occasional Discomfort for Back, Knees & Hands - Cartilage & Joint Health & Flexibility Support - 120 Gummies

Get the best cartilage and immune health support with these joint support gummies. Featuring Glucosamine Sulfate, the best form of Glucosamine for interaction with cartilage, and Vitamin E, a powerful antioxidant that supports joints and mobility. Each serving of 2 raspberry-flavored pectin plant-based gummies provides 160mg of Glucosamine Sulfate. These gummies are not only effective but also delicious and convenient. All Nature's Nutrition Products are certified by an independent 3rd party lab.

What We Like
Effective joint relief
Good taste
Convenient gummies
Timely delivery
Affordable price
What We Don't Like
Short shelf life
#TOP 5

Osteo Bi-Flex Triple Strength Glucosamine

12587823
Osteo Bi-Flex Triple Strength Glucosamine Cover
Osteo Bi-Flex Glucosamine Triple Strength Plus Turmeric Supplement with Curcumin for Joint Support and Range of Motion, 60 Day Supply, 120 Coated Tablets, Joint Health Nutritional Supplements

Osteo Bi-Flex Joint Supplements provide comprehensive support for your joints. With a generous 120 tablets per bottle, this glucosamine formula is designed for long-term joint nourishment. It features Joint Shield 5-LOXIN Advanced, an herbal extract that can enhance joint comfort within just a week of use. Additionally, the inclusion of glucosamine chondroitin helps strengthen your joints over time. Plus, the turmeric in this supplement offers antioxidant benefits, helping to protect your joints from oxidative stress. Overall, these supplements are a great choice for anyone looking to maintain joint health and mobility.

What We Like
Effective for knee pain relief
Trusted brand with good reputation
Contains turmeric for added benefits
Large bottle with plenty of tablets
What We Don't Like
Some users found no improvement
Tablets larger than expected
#TOP 6

S RAW SCIENCE Glucosamine Chondroitin MSM Supplement Capsules

S RAW SCIENCE
S RAW SCIENCE Glucosamine Chondroitin MSM Supplement Capsules Cover
Glucosamine Chondroitin MSM Capsules - Joint Support Supplement for Adults, 2800 mg Triple Strength Vitamins: Glucosamine HCL, Chondroitin Sulfate with OptiMSM - Reduces Joint Discomfort, 120 Capsules

S RAW SCIENCE Joint Supplement is a joint health supplement suitable for both men and women. Its unique and effective formula contains Glucosamine and Chondroitin sulfate capsules, which promote joint wellness, comfort, flexibility, and mobility. In addition, it contains MSM and Collagen Peptides, which provide a boost to not only your joints but also your hair, skin, and nails. This super joint support supplement can help you reduce discomfort for joints and improve joint function, making it easier for you to stay active and live a healthy lifestyle. It is ideal for those looking for a knee joint support supplement or something that can help with elbow joint support.

What We Like
Effective joint pain relief
Quick results within a week
Positive customer service experience
Husband noticed significant improvement
What We Don't Like
Not all ingredients effective
Some users prefer other brands
#TOP 7

Kirkland Signature Glucosamine HCI with MSM (Pack of 2)

multivitamins
Kirkland Signature Glucosamine HCI with MSM (Pack of 2) Cover
Kirkland Signature Glucosamine HCI (Pack of 2) Extra Strength with MSM,Tablet (375 Count X 2)

Kirkland Signature Glucosamine HCI with MSM (Pack of 2) is a chondroitin supplement that supports healthy joints and cartilage. It contains 1500 mg of Glucosamine HCI and 1500 mg of MSM. The product is USP verified, ensuring its quality and purity.

What We Like
Effective in reducing joint pain
Improves joint lubrication
Positive impact on knee health
Good value for healthy lifestyle
Long-term user satisfaction
What We Don't Like
Poor packaging experience
#TOP 8

Amazing Formulas Glucosamine Sulfate 1000mg 120 Capsules Supplement

9063
1 Count (Pack of 1)
Amazing Formulas Glucosamine Sulfate 1000mg 120 Capsules Supplement Cover
Amazing Formulas Glucosamine Sulfate 1000 mg Capsules Supplement | Non-GMO | Gluten Free | Made in USA (Unflavored)

The Amazing Formulas Glucosamine Sulfate Supplement comes in 120 capsules with 1000mg of Glucosamine Sulfate per serving. The supplement is Non-GMO and Gluten-Free. It is manufactured in accordance with GMP Standards and is third-party tested for purity and potency. The product is proudly made in the USA.

What We Like
Effective for joint pain
Helps with arthritis symptoms
Long-term positive results
Affordable price
Stomach-friendly
What We Don't Like
Large capsule size
Inconsistent capsule fill
#TOP 9

NOW Glucosamine & MSM (GreenGrown® Glucosamine)

3130
Cream
NOW Glucosamine & MSM (GreenGrown® Glucosamine) Cover
NOW Foods Supplements, Glucosamine & MSM (GreenGrown® Glucosamine), Vegetarian, 120 Veg Capsules

NOW Glucosamine & MSM is a vegetarian-friendly joint support supplement that combines two well-known ingredients - glucosamine and MSM. Glucosamine is essential for the formation of cartilage tissue, providing joint mobility and comfort. MSM, on the other hand, supports overall joint health. This supplement is made without gluten, dairy, nuts, and soy, making it suitable for various dietary needs. Additionally, it is non-GMO and vegan/vegetarian. With NPA A-rated GMP certification, you can trust the quality and efficacy of this product. NOW Glucosamine & MSM is a reliable choice for those seeking joint support and overall joint health.

What We Like
Vegetarian formula for shellfish allergies
Effective for joint pain relief
Good value compared to competitors
Positive impact on mobility
Helps reduce reliance on pain medications
What We Don't Like
Some users report less effectiveness
Vegetarian tablets might be less potent
#TOP 10

NOW Glucosamine 1000

3237
Off White
NOW Glucosamine 1000 Cover
NOW Foods Supplements, Glucosamine '1000', with UL Dietary Supplement Certification, 1 g Per Capsule, 60 Veg Capsules

NOW Joint Support is a dietary supplement designed to support healthy joint function and cartilage formation. It contains the highest grade glucosamine and is certified by UL Dietary Supplement. With 1g per capsule and 60 veg capsules per bottle, this supplement is a convenient way to maintain joint health. The manufacturer has recently changed the product ingredient to a vegetarian capsule, and Amazon offers replacements for non-vcap shipments. Adding NOW Joint Support to your daily routine can help improve joint mobility, reduce stiffness, and support overall joint health.

What We Like
Cost-effective supplement
High-quality ingredients
Effective for joint health
Easy to administer
Long-term user satisfaction
What We Don't Like
Chondroitin may cause discomfort
Limited product variations
Buying Guide Image

Frequently Asked Questions (FAQs)

1. Is it OK to take glucosamine everyday?

It is generally considered safe to take glucosamine every day, but it is advisable to consult with a healthcare provider. The recommended dosage for osteoarthritis is typically around 1,500 milligrams per day, taken in divided doses.

2. Does glucosamine really work for joints?

The effectiveness of glucosamine for improving joint health is debated. Some studies have not found significant evidence that glucosamine provides major benefits for joint health or the prevention of arthritis progression. However, individual responses may vary, and some people may still experience positive effects on joint health and flexibility.

3. Is turmeric better than glucosamine?

Turmeric and glucosamine have different focuses when it comes to joint health. Glucosamine is primarily aimed at improving joint health, while turmeric is considered a multi-purpose 'superfood.' Both can be safe for daily supplementation and have their own ways of supporting joint health and flexibility.

4. Are there any benefits to taking glucosamine?

Glucosamine is a building block for tendons, ligaments, cartilage, and joint fluid. Taking glucosamine supplements may potentially increase cartilage and joint fluid, and help prevent their breakdown. However, the extent of these benefits may vary among individuals.

5. Is glucosamine hard on the liver?

There have been isolated case reports suggesting that glucosamine may cause liver injury. However, the specific role of glucosamine in liver injury has not been fully established, and it is believed to be very rare if it occurs at all.

6. Does glucosamine really rebuild cartilage?

Glucosamine supplements have shown potential in delaying the breakdown of and repairing damaged cartilage, based on animal studies. However, further research is needed to establish its effectiveness in rebuilding cartilage in humans.

7. Which is better for joint pain turmeric or curcumin?

There is no consensus on whether it is better to take turmeric or curcumin supplements for joint pain. Most studies use extracted turmeric with a high concentration of curcumin or curcumin alone. Both turmeric and curcumin have shown potential in reducing joint inflammation, as well as providing other health benefits.

Editor's Notes

During our glucosamine nutritional supplement research, we found 24 glucosamine nutritional supplement products and shortlisted 10 quality products. We collected and analyzed 123,550 customer reviews through our big data system to write the glucosamine nutritional supplement list. We found that most customers choose glucosamine nutritional supplement with an average price of $19.43.

The glucosamine nutritional supplement are available for purchase. We have researched hundreds of brands and picked the top brands of glucosamine nutritional supplement, including Nature's Way, KIRKLAND, Osteo Bi-Flex, Nature's Nutrition, S RAW SCIENCE. The seller of top 1 product has received honest feedback from 385 consumers with an average rating of 4.7.

Written by
Elisa Drew Avatar

Elisa Drew is a really professional copywriter specializing in baby products with five years of experience working as a pediatrician once. She has published a series of baby books purchased by over thirty thousand people in the United States.

Glucosamine Nutritional Supplement Comparison Table

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Brand Nature's Way KIRKLAND Osteo Bi-Flex Nature's Nutrition Osteo Bi-Flex S RAW SCIENCE KIRKLAND Amazing Nutrition NOW Foods NOW Foods
Flavor Berry Unflavored Unflavored Curcuma,Curcumin Unflavored Unflavored Unflavored Unflavored Vegetarian Unflavored
Unit Count 16 Fluid Ounces 375.0 Count 60 Count 120 Count 120 Count 120 Count 750.0 Count 1 Count 120 Count 60 Count
Item Form Liquid Tablet Tablet Gummy Tablet Capsule Tablet Capsule Capsule Capsule
Item Weight 1 Pounds 1.62 Pounds 0.22 Pounds 0.93 Pounds 8.62 Ounces 5.29 Ounces 1 Pounds 0.3 Pounds 0.12 Kilograms 3.68 ounces
Product Benefits Nutritional Support Cushion joints and supports movement, promotes healthy cartilage Joint Health Supplement Joint Support Supplement Bone & Joint Support Bone and Joint Vitamins, Inflammation Management, Joint Support, Unique & Effective Formula Bone & Joint Support Dietary Supplement Bone & Joint Support Bone & Joint Support
Item dimensions L x W x H 9 x 3 x 6.25 inches 4 x 4 x 7 inches 2.5 x 2.5 x 4.75 inches - 3.2 x 3.2 x 5.3 inches 4 x 2 x 2 inches 6 x 5 x 3.3 inches 3.15 x 2.36 x 1.57 inches 2.7 x 2.7 x 4.65 inches 1.95 x 1.95 x 4.3 inches
Diet Type Gluten Free Gluten Free Gluten Free Vegan - Gluten Free Gluten Free Gluten Free Vegan Halal
Primary Supplement Type Vitamin D3 B-Complex Glucosamine - Glucosamine Joint Shield 5-Loxin Advanced Turmeric - GLUCOSAMINE Glucosamine Glucosamine glucosamine
Special Ingredients Glucosamine Glucosamine Hydrochloride, Methylsulfonylmethane Glucosamine; Joint Shield 5-Loxin Advanced - Glucosamine; Joint Shield 5-Loxin Advanced, Turmeric Chondroitin Glucosamine Glucosamine - Glucosamine
FTB Score
ftb score rating icon 9.8
ftb score rating icon 9.7
ftb score rating icon 9.5
ftb score rating icon 9.3
ftb score rating icon 9.2
ftb score rating icon 9.1
ftb score rating icon 9.1
ftb score rating icon 9.0
ftb score rating icon 8.8
ftb score rating icon 8.8
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