Best Spray Weed Killers of 2025

Roundup Weed Killer is a powerful solution that eliminates tough weeds and grasses down to the root. It works quickly, becoming rainproof in just 30 minutes and showing visible results within hours. You can plant new vegetation within 1 to 30 days after applying. This product is suitable for use in various areas like flower beds, around trees, on walkways, driveways, fences, and foundations. The Pump ‘N Go 2 Sprayer makes application easier with an extendable wand for precise spraying without the need to bend over.

Roundup 365 Weed Killer offers an effective solution for tackling weeds and grasses for an entire year. With its powerful formula, you can eliminate tough weeds like clover and poison ivy while also preventing new growth. This product is rainproof in just 30 minutes, ensuring that your hard work won't be washed away. You'll see visible results within hours, giving you quick satisfaction. The included Pump 'N Go 2 Sprayer allows for easy application, letting you spray continuously for up to 10 minutes without straining your back.

Ortho WeedClear Weed Killer for Lawns Ready-To-Spray is a liquid weed killer that kills over 250 common weeds, including dandelions, clover, poison ivy, chickweed, and dollarweed. It contains three proven ingredients that target common lawn weeds, so it won't harm your grass (when used as directed). Visible results can be seen in hours, and it is rainproof in 1 hour upon drying. It is easy to use, just connect your garden hose to the sprayer and set the nozzle to your desired setting.

JUST FOR PETS Weed Killer Spray is a natural and pet-friendly solution to weed problems. The product includes natural ingredients and is glyphosate-free, making it safe for pets and plants. It requires no mixing, just spray as directed, and it eliminates weeds fast. The company is community-minded, donating a portion of each sale to animal shelters nationwide.

Earth's Ally Weed Control Spray is a natural herbicide that kills common weeds like broadleaf, crabgrass, dandelion, clover, ivy, and chickweed to the roots. It uses sea salt instead of harsh synthetic chemicals, providing a pet-safe alternative. With visible results in 3 hours on a dry, sunny day, this spray is easy to use with its garden sprayer. Safe for people, pets, and the planet, it's ideal for high foot-traffic areas like patios, driveways, and sidewalks. Plus, it's bee-safe, independently tested to protect pollinators.

Green Gobbler 20% Vinegar Weed & Grass Killer is a natural and organic weed and grass killer that is certified for organic use. It is four times stronger than traditional table vinegar and is glyphosate-free. It is perfect for residential, commercial, industrial and agricultural use and is ready to use right out of the container. It eliminates and desiccates weeds and grasses in just a matter of hours and customers report full desiccation in less than 24 hours.

Ortho Weed Killer is designed to tackle even the most stubborn weeds and grasses, ensuring they are eliminated right down to the root. This means you won't have to worry about them returning. It works quickly, absorbing on contact to start killing weeds immediately and is rainproof just 15 minutes after you apply it. For the best results, use it when weeds are actively growing and temperatures are over 60°F. You can easily apply it in various areas, including flower beds, around trees, and on hard surfaces like patios and driveways, thanks to the convenient trigger sprayer.

Spectracide Weed & Grass Killer Refill is a fast-acting formula that kills weeds and grasses on driveways, walkways, and around trees and flower beds. It is rainfast and kills the root, so you can replant new flowers, trees, and shrubs the same weekend. It is also compatible with the AccuShot continuous power sprayer (sold separately).

Ortho WeedClear Lawn Weed Killer Ready to Spray is a ready-to-use weed killer that kills all major broadleaf weeds, including dandelion, chickweed and crabgrass. It is rainproof in 1 hour and delivers visible results in hours, after just one application. It is suitable for grasses including Bermudagrass, Buffalograss, Tall Fescue, Fine Fescues, Kentucky Bluegrass, Ryegrass, and Zoysiagrass, and can treat up to 5,000 sq. ft. with a garden hose. Customers have found it to be effective on a variety of broadleaf weeds, though it may require multiple applications for full eradication.

The BioAdvanced Weed Killer is designed for effective weed control in your garden. With its root kill action, it targets unwanted plants right at the source, ensuring they don’t come back. You can expect to see visible results in just three hours, letting you know the product is working quickly. Additionally, it becomes rainproof within ten minutes, so you don’t have to worry about unexpected weather ruining your efforts. Plus, it only kills the areas you spray, allowing for precise application and protecting your desired plants.