Best Ergonomic PC Gaming Mice of 2025

The Razer Basilisk V3 Gaming Mouse is a top-of-the-line device that offers gamers a wide range of features that can be customized to suit their needs. This mouse is ergonomically designed with a thumb rest and optimally positioned buttons for quick and easy access. With 11 programmable buttons, users can assign macros and secondary functions to execute essential actions. Its 11 Razer Chroma RGB lighting zones allow users to customize each zone from over 16.8 million colors and countless lighting effects. Additionally, its Optical Mouse Switches Gen 2 ensure crisp, responsive execution at a blistering 0.2ms actuation speed for up to 70 million clicks. The mouse also features a Focus+ 26K DPI Optical Sensor for pixel-precise accuracy.

The Redragon wireless gaming mouse is fully programmable, allowing you to remap buttons, set complex macro functions, change RGB backlit effects, adjust DPI in a wide range, and customize settings via the Redragon driver. With 9 adjustable RGB backlit modes, rapid fire button, high precision sensor, and ultra-long battery life, this mouse is perfect for gaming and working. It also comes with a 24-month warranty and professional after-sales service.

The Redragon M602-RGB Wired Gaming Mouse is a must-have for serious gamers. Its high-precision sensor and gaming-grade micro switches deliver pinpoint accuracy, extreme responsiveness, and greater durability. With up to 7200 DPI, 10G acceleration, and 7 programmable buttons, this mouse gives you an edge over your competition. Its ergonomic design ensures comfort and reduced click fatigue, while the 7 different backlight modes provide total personalization. The built-in weight tuning, anti-skid scroll wheel, and durable smooth TEFLON feet pads offer ultimate gaming control. Compatible with Windows and Mac OS, this mouse is a great addition to any gaming computer or laptop.

The Redragon M908 Impact RGB LED MMO Mouse is a professional gaming mouse with up to 12400 DPI, 5 adjustable DPI levels, and a high-precision Pixart PAW3327 Sensor. It also features 18 programmable buttons, 16.8 million RGB LED color options, and comes with an 8-piece weight tuning set. The mouse is designed for comfort and precision, with durable smooth TEFLON feet pads and a 6ft braided-fiber cable with gold-plated USB connector. Compatible with Windows and Mac OS systems.

The Redragon M612 Predator RGB Gaming Mouse has 5 redefinable DPI levels, 11 programmable buttons, and 5 decent backlit modes. The skin-friendly frosted coating provides a comfortable grip experience, and the ergonomic design minimizes fatigue even after hours of use. The mouse can be customized for both gaming and work purposes, with customizable tactical keybinds and a rapid fire button. The dynamic RGB backlit vibe adds to the gaming experience, making it a great accessory for any gaming space.

The MOJO Gaming Mouse is designed to enhance your gaming and working experience with its ergonomic vertical shape, ensuring comfort for your hands, wrists, and elbows. Featuring silent buttons, you can enjoy gaming late into the night without disturbing others around you. With 12 customizable buttons and dedicated gaming software, you can easily set up profiles, macros, and adjust the DPI settings to match your gameplay needs. The advanced PMW 3325 gaming sensor allows for precise movements with adjustable DPI from 1000 to 10000, making it ideal for both casual and competitive gamers.

The TRELC Ergonomic Gaming Mouse is designed to reduce wrist strain, muscle pain, Carpal Tunnel Syndrome and tendinitis with its natural handshake grip. It features a 5 Direction Rocker that helps gamers achieve their best performance in different types of games. With the intelligent macro defining function, users can customize all 11 buttons, and preset RGB Led Light can be customized to increase the game atmosphere. Additionally, the high configuration with 5 level DPI and PMW3325 photoelectric chip ensures superior gameplay.

The SOLAKAKA Gaming Mouse offers impressive features for gamers and office users alike. With 6 adjustable DPI settings up to 12800, you can easily tailor the sensitivity to match your gaming style or work requirements. The mouse also includes four modes, allowing you to switch between office and gaming settings effortlessly. Additionally, you can customize the buttons and lighting effects through macro programming, giving you complete control over your gaming experience. Its ergonomic honeycomb shell design ensures comfort during long sessions, reducing fatigue and enhancing breathability.

The ZLOT Gaming Mouse features an ergonomic vertical design that helps reduce wrist strain, making it ideal for long gaming sessions. Its advanced Pixart PMW3325 IR sensor offers five adjustable DPI levels, allowing you to customize your sensitivity based on your gaming needs. You’ll also appreciate the customizable RGB lighting that adds a stylish touch to your setup. With 11 programmable buttons, this mouse lets you tailor your commands for a more efficient gaming experience. Overall, it combines comfort and functionality to enhance your gameplay.

The UtechSmart Venus Pro RGB Wireless MMO Gaming Mouse is a perfect combination of comfort and performance. With 16 programmable buttons, you can easily customize complex button macro coding to improve your gaming skills and reduce response time. The ergonomic design ensures that you can comfortably hold the mouse for long gaming sessions. The mouse has a high precision optical sensor which offers up to 16000 DPI with 5 DPI switchable stages and 1000 Hz polling rate. The dual modes with ultra-speed wireless technology provide stable and fast data transmission with 10-meter reception boundary. The mouse comes with fully customizable RGB lighting up to 16 Million colors and 4 programmable RGB modes. Lastly, the endurable battery lifetime offers up to 70 hours of wireless mode, allowing you to enjoy long gaming sessions without worrying about charging.