Best Mushrooms Supplements for Immune Support of 2025

Elisa Drew Avatar
Elisa Drew
Last Updated: Jan 9, 2025

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Mushroom supplements are gaining popularity as an effective way to boost the immune system. These supplements are made from a variety of mushrooms, including shiitake, maitake, and reishi, which are known for their immune-boosting properties. They contain beta-glucans, which stimulate the immune system by increasing the production of white blood cells. Mushroom supplements also contain polysaccharides, which have anti-inflammatory properties and can help to reduce inflammation in the body. These supplements are a natural and safe way to support the immune system and protect against illness.

At a Glance: Our Top Picks

Host Defense MyCommunity Capsules Cover #TOP 1
Host Defense MyCommunity Capsules
ftb score rating icon 9.8
Genius Mushroom Supplement Cover #TOP 2
Genius Mushroom Supplement
ftb score rating icon 9.7
DEAL SUPPLEMENT Organic Mushroom 10-in-1 Defense Capsules Cover #TOP 3
DEAL SUPPLEMENT Organic Mushroom 10-in-1 Defense Capsules
ftb score rating icon 9.5

Top 10 Mushrooms Supplements for Immune Support

#TOP 1

Host Defense MyCommunity Capsules

NCMC120
Host Defense MyCommunity Capsules Cover
Host Defense MyCommunity Capsules - 17 Species Blend Mushroom Supplement for Immune Support - Herbal Aid with Lion's Mane, Reishi. Chaga, Cordyceps, Turkey Tail & More - 120 Capsules (60 Servings)*

Host Defense MyCommunity Capsules are a powerful mushroom supplement designed to support your immune system. With 17 different mushrooms, including Lion's Mane, Reishi, Turkey Tail, Chaga, Cordyceps, and Amadou mushroom mycelium, these capsules provide high-intensity immune support and help fend off free radical damage. They can be taken once daily with food or on an empty stomach as a dietary supplement, making them a simple and convenient addition to your daily health regimen. Plus, they are sustainably cultivated, certified organic, and made with USA-grown mushrooms.

What We Like
Boosts immune system
Effective in combating colds and illnesses
Easy to swallow and flavorless

Genius Mushroom Supplement

GEN1006/100/101
Cream
Genius Mushroom Supplement Cover
Genius Mushroom Supplement - Lions Mane, Cordyceps, Reishi - Brain Nootropic for Energy, Focus, Overall Wellness, & Immune Support - 90 Capsules

Genius Mushroom Supplement is a unique blend of three of the most researched mycological species on the planet. This organic formula enhances mental clarity, immune function, natural energy, and more. It is a caffeine-free energy supplement that elevates energy levels naturally via ATP production with Cordyceps Sinensis. The Lions Mane provides a safe alternative to highly questionable nootropics and smart drugs hitting the market nowadays. This species is a proven brain booster, great for work and studying. The Reishi mushroom extract elevates immune support to another level. It has been used for centuries as an immune booster to stay healthy and avoid the common cold. Reishi has also been shown to improve mood and potentially act as a detoxifying liver cleanse. There isn't another formula on the market that delivers like this.

What We Like
Boosts immune system
Enhances brain function
Natural energy support

DEAL SUPPLEMENT Organic Mushroom 10-in-1 Defense Capsules

TS0417-B700ML-M1835
DEAL SUPPLEMENT Organic Mushroom 10-in-1 Defense Capsules Cover
Organic 10-in-1 Mushroom Supplement 8,000mg Per Serving, 240 Capsules – Lions Mane, Turkey Tail, Reishi, Cordyceps & More Mushroom Complex – Immune, Energy & Nootropic Brain Support – Non-GMO

DEAL SUPPLEMENT Mushroom Defense Capsules offer a unique blend of 10 organic mushrooms grown in the US. This ultimate adaptogenic complex provides concentrated immune, energy, and brain support. With 240 capsules per bottle, each serving gives you a powerful 8,000mg herbal equivalent. The mushrooms, including Lions Mane and Chaga, have been trusted for centuries for their adaptogens, antioxidants, and vitamins. Plus, the product is Non-GMO and free from common allergens, ensuring quality and safety.

What We Like
Organic 10-in-1 Blend
Immune & Energy Support
Brain Nootropic Health

Real Mushrooms 5 Defenders Capsules

RM-5D45C
Brown
Real Mushrooms 5 Defenders Capsules Cover
Real Mushrooms 5 Defenders Capsules - Organic Mushroom Extract w/Chaga, Shiitake, Maitake, Turkey Tail, & Reishi - Mushroom Supplement for Focus, & Immune Support - Vegan, Non-GMO, 90 Caps

Real Mushrooms 5 Defenders Capsules is an organic mushroom extract supplement that contains five types of mushrooms to support your immune system. It's made from 100% mushrooms, not mycelium grown on grain, and is rich in beta-glucans, triterpenes, and nutrients. It's also gluten-free, non-GMO, and vegan, making it easy for anyone to consume. The capsules are measured for beta-glucans and verified by 3rd-party labs. Adults can take 2 capsules daily or add them to their meals or drinks as needed. Real Mushrooms products are carefully sourced and processed for potency and efficacy.

What We Like
Contains five types of mushrooms for natural immune support
100% pure mushroom extract with no grains, additives, or fillers
Measured for beta-glucans and verified by 3rd-party labs
Easy to consume for anyone as it's gluten-free, non-GMO, and vegan
Carefully sourced and processed for potency and efficacy
#TOP 5

DailyNutra Mushroom Defense Formula

DN-MushroomD-Single
DailyNutra Mushroom Defense Formula Cover
DailyNutra Mushroom Defense Formula - Immune Support Supplement | Organic Mushrooms, Hot Water Extracted - Reishi, Chaga, Maitake, Shiitake & Turkey Tail (90 Capsules)

DailyNutra Mushroom Defense Formula is a potent blend of five medicinal mushroom extracts that works to strengthen your immune system and promote deep healing. The blend includes Reishi, Chaga, Maitake, Shiitake, and Turkey Tail mushrooms, which are known for their ability to fortify the immune system. The supplements are made from organic, premium mushrooms that are hot water extracted from high-potency fruiting bodies. They are all-natural, vegetarian, gluten-free, and free of fillers, preservatives, or synthetics. The product comes with a 100% satisfaction guarantee.

What We Like
Potent blend of five medicinal mushroom extracts to strengthen your immune system
Organic, premium mushrooms with no added starch or grains
All-natural formula made from plant-based extracts, vegetarian, gluten-free, and free of fillers, preservatives, or synthetics
#TOP 6

Gaia Herbs Immune Mushroom Blend

90C35040
Gaia Herbs Immune Mushroom Blend Cover
Gaia Herbs Immune Mushroom Blend - Immune Support Mushroom Supplement for Year-Round Health* - with Reishi, Cordyceps, Turkey Tail, Shiitake, and Chaga Mushrooms - 40 Vegan Capsules (40-Day Supply)

Gaia Herbs Immune Mushroom Blend is a mushroom supplement that can help maintain overall good health. The blend includes five potent immune-supporting mushrooms including Reishi, Cordyceps, Turkey Tail, Shiitake, and Chaga. With 2,500mg of dried mushrooms per serving, the 100% Mushroom Extract is free from fillers, grains, or starch. It is vegan, gluten-free, and proudly made in NC, USA. This formula can help your body build its immune defenses to support your well-being all year long.

What We Like
100% Mushroom Extract with no fillers
Includes potent immune-supporting mushrooms
Vegan and gluten-free

Wild & Organic Immune Mushroom Supplement Complex

4 Fl Oz (Pack of 1)
Wild & Organic Immune Mushroom Supplement Complex Cover
Wild & Organic Immune Mushroom Tincture - Mushroom Complex 8-in-1 Immune Support Supplement - Lions Mane Supplement w/Turkey Tail, Reishi, Shiitake Mushrooms - Mushroom Supplement Liquid - 4 oz

Introducing the Wild & Organic Mushroom Drops, a powerful 8-in-1 organic mushroom extract complex designed to support your immune system. This vegan supplement contains extracts from agaricus, chaga, turkey tail, lion's mane, reishi, maitake, agarikon, and shiitake mushrooms, all packed with antioxidants and protein. With a natural formula delivering 682mg per 0.7ml serving, these mushroom tinctures are non-GMO and sugar-free. The liquid format makes it easier to take than capsules or pills, and it can be quickly absorbed since there are no solid components to digest. As a family-owned business based in California, Wild & Organic ensures quality by locally making and testing their tincture drops according to industry standards. Rest assured, your satisfaction is their top priority, and they offer a hassle-free return or refund if the product doesn't meet your expectations.

What We Like
Powerful 8-in-1 Mushroom Complex
Natural and Vegan Formula
Easier to Take and Absorb
#TOP 8

Premium Kinoko Platinum AHCC Supplement

812259003370
Brown
Premium Kinoko Platinum AHCC Supplement Cover
Quality of Life Premium Kinoko Platinum AHCC Herbal Supplement, 750mg of AHCC per Capsule, for Immune Support, Liver Function, Maintains Natural Killer Cell Activity, 1 Pack, 60 Veggie Capsules

Quality of Life's Premium Kinoko Platinum AHCC Supplement is a proprietary blend of mushrooms that aims to support immune health, maintain natural killer cell activity, and liver function. Clinically proven in over 30 human clinical trials, the AHCC mushroom extract is rich in Alpha Glucans, a type of polysaccharide with potent immune-enhancing effects. The supplement is manufactured in a GMP certified facility that adheres to Good Manufacturing Practices, ensuring superior quality. It is a vegetarian supplement and is recommended for adult use.

What We Like
Clinically proven in over 30 human clinical trials
Rich in Alpha Glucans, a type of polysaccharide with potent immune-enhancing effects
Manufactured in a GMP certified facility that adheres to Good Manufacturing Practices
#TOP 9

Host Defense Lion's Mane Capsules

NCHE120
Host Defense Lion's Mane Capsules Cover
Host Defense Mushrooms Lion's Mane - Brain Health Support Supplement - Mushroom Supplement to Support Focus & Memory Function - Immune & Nervous System Support Supplement - 120 Capsules (60 Servings)*

Host Defense Lion's Mane Capsules are mushroom supplements that support cognitive function and immune health. With Lion's Mane mushroom mycelium, it clears the mental fog and boosts memory. It provides cerebral and nervous system support, optimizes immune system health, and can be taken with or without food. The vegetarian capsules are simple and convenient for daily use. The mushrooms are sustainably cultivated, certified organic, and U.S. grown.

What We Like
Supports cognitive function and immune health
Clears mental fog and boosts memory
Convenient and simple for daily use
Vegetarian capsules
Sustainably cultivated, certified organic, and U.S. grown mushrooms
#TOP 10

Host Defense Stamets 7 Capsules - Daily Immune Support

NCS7120
Host Defense Stamets 7 Capsules - Daily Immune Support Cover
Host Defense Stamets 7-7 Species Blend - Mushroom Supplement for Immune Support - Includes Royal Sun Blazei, Cordyceps, Reishi, Maitake, Lion's Mane, Chaga & Mesima - 120 Capsules (60 Servings)*

Host Defense Stamets 7 Capsules are a daily immune support mushroom supplement designed to enhance natural blood sugar modulation, respiratory and digestive health, and help your body adapt to stress. The 7 mushroom blend includes Lion's Mane, Reishi, Cordyceps and Chaga mushrooms. The vegetarian capsules can be taken once daily with food or on an empty stomach, providing a simple and convenient way to add organic mushroom mycelium into your daily health regimen. The sustainably cultivated, certified organic and USA grown mushrooms are safe and smart ingredients.

What We Like
Daily immune support
Enhances natural blood sugar modulation, respiratory and digestive health, and helps your body adapt to stress
Easy to take once daily with food or on an empty stomach
Simple and convenient way to add organic mushroom mycelium into your daily health regimen
Sustainably cultivated, certified organic and USA grown mushrooms
Buying Guide Image
Editor's Notes

During our mushrooms supplement for immune support research, we found 24 mushrooms supplement for immune support products and shortlisted 10 quality products. We collected and analyzed 210,558 customer reviews through our big data system to write the mushrooms supplements for immune support list. We found that most customers choose mushrooms supplements for immune support with an average price of $27.33.

The mushrooms supplements for immune support are available for purchase. We have researched hundreds of brands and picked the top brands of mushrooms supplements for immune support, including Host Defense, The Genius Brand, DEAL SUPPLEMENT, Real Mushrooms, DailyNutra. The seller of top 1 product has received honest feedback from 15,177 consumers with an average rating of 4.9.

Written by
Elisa Drew Avatar

Elisa Drew is a really professional copywriter specializing in baby products with five years of experience working as a pediatrician once. She has published a series of baby books purchased by over thirty thousand people in the United States.