Best Hypoallergenic Baby Formula of 2026

Elisa Drew Avatar
Elisa Drew
Last Updated: Jan 19, 2026

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Hypoallergenic baby formula is a specially designed formula for infants who have allergies or intolerances to cow's milk protein. This type of formula is made with hydrolyzed proteins, which means they are broken down into smaller pieces that are easier for babies to digest. Hypoallergenic formulas are also fortified with nutrients, such as iron, calcium, and vitamin D, to support the growth and development of infants. These formulas come in both liquid and powder forms and are available in a variety of brands. It is important to consult with a pediatrician before switching to a hypoallergenic formula to ensure it is the best option for the baby's needs.

At a Glance: Our Top Picks

Enfamil Nutramigen Hypoallergenic Baby Formula Cover #TOP 1
Enfamil Nutramigen Hypoallergenic Baby Formula
ftb score rating icon 9.8
Enfamil Nutramigen Hypoallergenic Formula Cover #TOP 2
Enfamil Nutramigen Hypoallergenic Formula
ftb score rating icon 9.7
Similac Alimentum Infant Formula Cover #TOP 3
Similac Alimentum Infant Formula
ftb score rating icon 9.5

Top 10 Hypoallergenic Baby Formula

Enfamil Nutramigen Hypoallergenic Baby Formula

Enfamil Nutramigen Hypoallergenic Baby Formula Cover
Enfamil Nutramigen Hypoallergenic Baby Formula with Iron, Lactose Free, Colic Relief from Cow's Milk Allergy Starts in 24 Hours, Brain Building DHA, Probiotic LGG for Immune Support, 27.8 Oz Can

Enfamil Nutramigen Formula is a gentle, lactose-free powder baby formula designed to help ease your little one's colic, providing fast relief within 48 hours. It features the superstar LGG probiotic, supporting your baby's digestive health. With nourishing brain development components like omega-3 DHA and ARA, it aids in your baby's brain growth. Additionally, it offers immunity support, helping your baby adapt to standard milk formula. Trusted by pediatricians, this formula is a top choice for managing cow's milk allergy, ensuring a happier, better-rested baby and mom.

What We Like
Relieves dairy allergy symptoms
Improves baby comfort and health
Effective for colic and allergies
High product quality
Best available deal
What We Don't Like
Higher price point
Occasional shipping damage

Enfamil Nutramigen Hypoallergenic Formula

Enf-9533
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Enfamil Nutramigen Hypoallergenic Formula Cover
Enfamil Nutramigen Hypoallergenic Baby Formula with Iron, Lactose Free, Colic Relief from Cow's Milk Allergy Starts in 24 Hours, Brain Building DHA, Probiotic LGG for Immune Support, 19.8 Oz Can

Enfamil Nutramigen Formula is designed to help ease your baby's colic caused by cow's milk allergies. It provides gentle relief, often reducing excessive crying in less than a day, making for a happier baby and a more restful parent. This formula features LGG probiotic, which supports your baby's digestive health, ensuring they feel their best. Additionally, it's hypoallergenic with hydrolyzed proteins, minimizing the risk of allergic reactions, and it's lactose-free, perfect for babies with lactose intolerance. With Nutramigen, you can feel confident knowing you're giving your little one a soothing solution.

What We Like
Effective for reflux
Relieves digestive issues
Helps milk protein allergy
No constipation
Improves baby's comfort
What We Don't Like
High price
Strong smell
#TOP 3

Similac Alimentum Infant Formula

Similac Alimentum Infant Formula Cover
Similac Alimentum With 2'-FL HMO Hypoallergenic Infant Formula, for Food Allergies and Colic Due to Protein Sensitivity, Baby Formula Powder, 19.8-oz Value Can

Similac Alimentum Formula by Similac is a hypoallergenic powder baby formula designed for infants with food allergies and colic. It contains a special milk protein that helps reduce allergic reactions in babies sensitive to cow's milk protein. This formula starts alleviating colic symptoms within 24 hours for most babies. Additionally, it is the first formula to include 2'-FL HMO, an immune-nourishing ingredient. Moreover, it is EBT eligible, making it accessible for purchase with SNAP benefits in select stores.

What We Like
Hypoallergenic formula
Relieves tummy troubles
Supports growth and health
Convenient ready-to-feed bottles
Easy on sensitive stomachs
What We Don't Like
Higher price
Powder less convenient
#TOP 4

Enfamil Nutramigen Hypoallergenic Baby Formula

300871239418
1 Can (12.6 oz)
Enfamil Nutramigen Hypoallergenic Baby Formula Cover
Enfamil Nutramigen Hypoallergenic Baby Formula with Iron, Lactose Free, Colic Relief from Cow's Milk Allergy Starts in 24 Hours, Brain Building DHA, Probiotic LGG for Immune Support, 12.6 Oz Can

Enfamil Nutramigen Formula offers fast relief for babies with cow's milk allergy, helping you see improvements as soon as the first feeding. It’s designed to ease colic symptoms quickly, with most infants showing progress within two days, making feeding times less stressful for you and your baby. This formula also supports long-term health by reducing the chances of future allergy problems, giving you peace of mind. Plus, it helps your baby gradually tolerate milk protein again without an allergic reaction, which can make feeding easier over time.

What We Like
Relieves acid reflux symptoms
Helps with milk allergy
Reduces fussiness and crying
Quick and noticeable results
Gentle on sensitive stomachs
What We Don't Like
High price
Strong smell
#TOP 5

Nutricia Pepticate Baby Formula

NUTRICIA PEPTICATE
Nutricia Pepticate Baby Formula Cover
Pepticate Baby Formula, Hypoallergenic Powdered Infant Formula for Cow Milk Allergy, with Omega 3 DHA, ARA, Iron & Prebiotics, 13.2oz

Pepticate Formula is a hypoallergenic powdered infant formula by Nutricia Pepticate, designed for infants with cow milk allergy. It has over 30 years of experience managing cow milk allergy symptoms like eczema and colic. Inspired by breast milk, it contains prebiotic oligosaccharides for digestive health, nucleotides for the immune system, and DHA plus ARA for brain and eye development. Made in Europe, it's a safe and well-tolerated formula trusted in over 75 countries.

What We Like
Great for sensitive stomachs
No bad taste or smell
Helps with allergies and eczema
Reduces spit-up and GI issues
Easy single ounce measurement
What We Don't Like
Higher price point
Taste less pleasant than regular formulas

Similac Alimentum Hypoallergenic Formula

57508
Similac Alimentum Hypoallergenic Formula Cover
Similac Alimentum with 2'-FL HMO Hypoallergenic Infant Formula, for Food Allergies and Colic Due to Protein Sensitivity, Ready-to-Feed Baby Formula, 8-fl-oz Bottle, Pack of 24

Similac Hypoallergenic Formula is designed for babies with food allergies and colic. It features a specially processed milk protein that minimizes the risk of allergic reactions for those sensitive to cow's milk. Most infants experience relief from colic symptoms within just 24 hours of use. Additionally, this formula includes 2'-FL HMO, an ingredient that supports your baby's immune health. As the top infant formula brand used in hospitals, you can trust its quality and effectiveness. Plus, you can earn rewards points by scanning the MySimilac QR code on select products, adding extra value to your purchase.

What We Like
Effective for dairy allergies
Reduces colic and reflux
Improves baby sleep and comfort
Convenient ready-to-feed packaging
Supports healthy weight gain
What We Don't Like
Strong unpleasant smell
Higher cost than regular formula
#TOP 7

Enfamil Nutramigen Infant Formula

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Enfamil Nutramigen Infant Formula Cover
Enfamil Nutramigen Hypoallergenic Baby Formula with Iron, Lactose Free, Colic Relief from Cow's Milk Allergy Starts in 24 Hours, Brain Building DHA, Probiotic LGG for Immune Support, 32 Fl Oz, 6 Count

Enfamil Nutramigen Formula is a liquid baby formula that provides fast relief from severe crying and colic due to cow's milk allergy. It includes LGG, a probiotic that supports digestive health, and important nutrients found in breast milk such as omega-3 DHA, ARA, and choline that provide brain support. This lactose-free formula helps support baby's immune system and is recommended by pediatricians. With 90% of infants improving within 48 hours, Enfamil Nutramigen Formula is a trusted brand for allergy management, brain-building, and immune support.

What We Like
Relieves colic and fussiness
Helps with digestive issues
Suitable for milk protein allergy
Promotes healthy growth
Subscription savings available
What We Don't Like
Higher price point
Strong smell
#TOP 8

Enfamil Nutramigen Infant Formula, Lactose Free, 6 Liquid Bottles (4 Count)

0529wl1085
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Enfamil Nutramigen Infant Formula, Lactose Free, 6 Liquid Bottles (4 Count) Cover
Enfamil Nutramigen Hypoallergenic Baby Formula with Iron, Lactose Free, Colic Relief from Cow's Milk Allergy Starts in 24 Hours, Brain Building DHA, Concentrated Liquid, 8 Fl Oz, 24 Bottles

The Enfamil Nutramigen Infant Formula is a lactose-free and hypoallergenic baby formula designed to provide fast relief from colic caused by cow's milk allergy. It includes LGG, a probiotic that helps manage allergies and supports digestion. Nutramigen also contains important nutrients like omega-3 DHA, ARA, and choline that provide brain and immune support for the baby. Clinically proven to provide relief as early as the first feeding, it helps the baby's immune system return to consuming traditional milk protein formula without an allergic response. Enfamil Nutramigen Infant Formula is the #1 trusted brand for brain-building and immune support, and is recommended by pediatricians.

What We Like
Soothes colic and fussiness
Improves digestion and bowel movements
Suitable for milk protein allergy
Supports healthy growth
Convenient subscription savings
What We Don't Like
High price
Occasional delivery delays
#TOP 9

Enfamil Nutramigen Infant Formula, Hypoallergenic and Lactose-Free Formula

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Enfamil Nutramigen Infant Formula, Hypoallergenic and Lactose-Free Formula Cover
Enfamil Nutramigen Hypoallergenic Baby Formula with Iron, Lactose Free, Colic Relief from Cow's Milk Allergy Starts in 24 Hours, Brain Building DHA, Probiotic LGG for Immune Support, 27.8 Oz, 4 Count

Enfamil Nutramigen is a lactose-free baby formula that helps ease colic and provides fast relief. It includes LGG, an extensively studied probiotic for allergy management and supports the digestive health of your baby. Additionally, Nutramigen has important nutrients found in breast milk such as omega-3 DHA, ARA, and choline that provide brain support and helps support the baby's immune system to return to consuming traditional milk protein formula without an allergic response. Enfamil is the #1 Trusted Brand for Brain-building & Immune Support and is pediatrician recommended.

What We Like
Effective for dairy allergies
Relieves colic symptoms
Improves baby's well-being
Best deal for quantity
What We Don't Like
Higher price point
Occasional packaging issues
#TOP 10

Nutricia Pepticate Hypoallergenic Baby Formula

NUTRICIA PEPTICATE
Nutricia Pepticate Hypoallergenic Baby Formula Cover
Pepticate Baby Formula, Hypoallergenic Powdered Infant Formula for Cow Milk Allergy, with Omega 3 DHA, ARA, Iron & Prebiotics, 13.2oz (Pack of 4)

Nutricia Pepticate Formula is designed for babies with cow milk allergy, offering a gentle and effective feeding option. This hypoallergenic formula helps manage allergy symptoms like eczema and colic, making mealtimes more comfortable for your little one. Inspired by breast milk, it includes prebiotics to support digestion and immune health, along with DHA and ARA that promote brain and eye development. Backed by over 30 years of European expertise, this formula ensures your baby receives balanced nutrition while easing allergy concerns, giving you peace of mind and your baby a healthy start.

What We Like
Gentle on sensitive stomachs
Helps with reflux and spit-up
Mild taste and smell
Suitable for allergies and intolerances
Easy single-ounce measurement
What We Don't Like
Higher price point
Taste less appealing than regular formulas
Buying Guide Image

Best Choices of Hypoallergenic Baby Formula for Babies

What is Hypoallergenic Baby Formula?

Hypoallergenic baby formula is a type of formula that is specifically designed for infants who have allergies or sensitivities to certain proteins found in regular infant formula. These formulas are made with proteins that have been extensively hydrolyzed, which means they have been broken down into smaller pieces. This makes it easier for babies to digest the formula and reduces the likelihood of an allergic reaction.

Why Choose Hypoallergenic Baby Formula?

Babies who have allergies or sensitivities to proteins in regular formula may experience symptoms such as vomiting, diarrhea, constipation, eczema, and gas. These symptoms can be uncomfortable and even painful for your baby. By choosing a hypoallergenic formula, you can help reduce the likelihood of these symptoms and provide your baby with the nutrition they need to grow and thrive.

How to Choose the Right Hypoallergenic Baby Formula

When choosing a hypoallergenic baby formula, there are a few key factors to consider. First and foremost, it's important to talk to your baby's doctor about their specific needs and allergies. Your doctor can provide guidance on which type of formula is best for your baby and any potential risks or concerns.

Once you have your doctor's recommendations, you can start looking for a formula that meets your baby's needs. Some key things to look for include:

  • Extensively hydrolyzed protein: As mentioned above, extensively hydrolyzed protein is key for reducing the likelihood of an allergic reaction. Make sure the formula you choose has this type of protein.

  • Non-GMO ingredients: Non-GMO ingredients are not genetically modified and are considered to be safer and more natural. Look for a formula that is made with non-GMO ingredients.

  • Organic: Organic formulas are made with ingredients that are grown without the use of synthetic pesticides, herbicides, and fertilizers. If you're concerned about the purity and quality of the ingredients in your baby's formula, look for an organic option.

  • Age-appropriate: As your baby grows and develops, their nutritional needs will change. Make sure the formula you choose is appropriate for your baby's age.

Conclusion

Choosing a hypoallergenic baby formula can be a challenging task, but it's important for the health and well-being of your little one. By considering your baby's specific needs and allergies, and looking for a formula with extensively hydrolyzed protein, non-GMO ingredients, and organic options, you can help ensure that your baby gets the nutrition they need without the risk of an allergic reaction.

Frequently Asked Questions (FAQs)

1. What is the difference between Alimentum and Nutramigen?

The main difference between Alimentum and Nutramigen is the type of sugars used. Nutramigen contains corn syrup, while Alimentum has corn maltodextrin. Corn syrup is higher in sugar content compared to maltodextrin. Both formulas do not contain artificial growth hormones.

2. Does hypoallergenic formula make babies gassy?

Hypoallergenic formulas are formulated with proteins that are broken down into easier-to-digest proteins, which can be beneficial for gassy babies. These specialized formulas contain different carbohydrates and proteins that may work better for babies who experience gassiness.

3. What is the disadvantage of hypoallergenic formula?

One disadvantage of hypoallergenic formula is the smell and taste. The milk proteins in these formulas are broken down into small peptides and individual amino acids, resulting in a bitter taste. However, babies often accept these formulas well despite the unappealing smell and taste.

4. How long does it take for baby to adjust to hypoallergenic formula?

While many babies have no issues switching formulas, it can take 3 to 5 days for babies to become used to a new formula, especially hypoallergenic formulas. These formulas may have a different smell and taste, which can require some adjustment for the baby.

5. Do babies poop more on hypoallergenic formula?

In general, babies tend to poop less often on hypoallergenic amino acid-based formulas. These formulas are designed to be easily absorbed by the baby's digestive system, and they do not contain fiber. As a result, babies may have fewer bowel movements when on hypoallergenic formulas.

Editor's Notes

During our hypoallergenic baby formula research, we found 24 hypoallergenic baby formula products and shortlisted 10 quality products. We collected and analyzed 108,057 customer reviews through our big data system to write the hypoallergenic baby formula list. We found that most customers choose hypoallergenic baby formula with an average price of $49.44.

The hypoallergenic baby formula are available for purchase. We have researched hundreds of brands and picked the top brands of hypoallergenic baby formula, including Enfamil, Similac, NUTRICIA PEPTICATE. The seller of top 1 product has received honest feedback from 384 consumers with an average rating of 4.7.

Written by
Elisa Drew Avatar

Elisa Drew is a really professional copywriter specializing in baby products with five years of experience working as a pediatrician once. She has published a series of baby books purchased by over thirty thousand people in the United States.

Hypoallergenic Baby Formula Comparison Table

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Brand Enfamil Enfamil Similac Enfamil NUTRICIA PEPTICATE Similac Enfamil Enfamil Enfamil NUTRICIA PEPTICATE
Size 27.8 Ounce (Pack of 1) 19.8 Ounce (Pack of 1) 19.8 Ounce (Pack of 1) 1 Can (12.6 oz) 13.2 Ounce (Pack of 1) 8 Fl Oz (Pack of 24) 32 Fl Oz (Pack of 6) 8 Fl Oz (Pack of 24) 27.8 Ounce (Pack of 4) 13.2 Ounce (Pack of 4)
Item Form Powder Powder Powder Powder Powder Liquid Liquid Liquid Powder Powder
Item Weight 27.8 Ounces 19.8 Ounces - 12.64 ounces - 10.53 ounces 13.9 Pounds - 0.01 Ounces 4 Pounds
Age Range (Description) - - Infant Infant Infant Infant - Baby - Infant
Manufacturer recommended age 0 - 1 months 0 - 1 months - 3 months and up - - 0 - 10 months - 0 - 1 months -
Allergen Information Milk Eggs, Fish, Milk, Peanuts, Sesame Seeds, Shellfish, Soy, Tree Nuts, Wheat Milk, Soy - - - Milk - Milk -
FTB Score
ftb score rating icon 9.8
ftb score rating icon 9.7
ftb score rating icon 9.5
ftb score rating icon 9.4
ftb score rating icon 9.4
ftb score rating icon 9.4
ftb score rating icon 9.3
ftb score rating icon 9.3
ftb score rating icon 9.3
ftb score rating icon 9.2
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