Best Hypoallergenic Baby Formula of 2025

Elisa Drew Avatar
Elisa Drew
Last Updated: Jan 17, 2025

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Hypoallergenic baby formula is a specially designed formula for infants who have allergies or intolerances to cow's milk protein. This type of formula is made with hydrolyzed proteins, which means they are broken down into smaller pieces that are easier for babies to digest. Hypoallergenic formulas are also fortified with nutrients, such as iron, calcium, and vitamin D, to support the growth and development of infants. These formulas come in both liquid and powder forms and are available in a variety of brands. It is important to consult with a pediatrician before switching to a hypoallergenic formula to ensure it is the best option for the baby's needs.

At a Glance: Our Top Picks

Enfamil Nutramigen Hypoallergenic Baby Formula Cover #TOP 1
Enfamil Nutramigen Hypoallergenic Baby Formula
ftb score rating icon 9.8
Similac Alimentum Infant Formula Cover #TOP 2
Similac Alimentum Infant Formula
ftb score rating icon 9.7
Nutricia Pepticate Baby Formula Cover #TOP 3
Nutricia Pepticate Baby Formula
ftb score rating icon 9.5

Top 10 Hypoallergenic Baby Formula

Enfamil Nutramigen Hypoallergenic Baby Formula

Enfamil Nutramigen Hypoallergenic Baby Formula Cover
Enfamil Nutramigen Hypoallergenic Baby Formula with Iron, Lactose Free, Colic Relief from Cow's Milk Allergy Starts in 24 Hours, Brain Building DHA, Probiotic LGG for Immune Support, 27.8 Oz Can

Enfamil Nutramigen Formula is a gentle, lactose-free powder baby formula designed to help ease your little one's colic, providing fast relief within 48 hours. It features the superstar LGG probiotic, supporting your baby's digestive health. With nourishing brain development components like omega-3 DHA and ARA, it aids in your baby's brain growth. Additionally, it offers immunity support, helping your baby adapt to standard milk formula. Trusted by pediatricians, this formula is a top choice for managing cow's milk allergy, ensuring a happier, better-rested baby and mom.

What We Like
Effective for cow milk allergies
Easy ordering and fast delivery
Reliable quality and safety
Significant weight gain improvement
Better pricing than local stores
What We Don't Like
Pricey compared to other formulas
Large can lasts about a week
#TOP 2

Similac Alimentum Infant Formula

Similac Alimentum Infant Formula Cover
Similac Alimentum with 2’-FL HMO Hypoallergenic Infant Formula, for Food Allergies and Colic, Suitable for Lactose Sensitivity, Baby Formula Powder, 19.8-oz Value Can

Similac Alimentum Formula by Similac is a hypoallergenic powder baby formula designed for infants with food allergies and colic. It contains a special milk protein that helps reduce allergic reactions in babies sensitive to cow's milk protein. This formula starts alleviating colic symptoms within 24 hours for most babies. Additionally, it is the first formula to include 2'-FL HMO, an immune-nourishing ingredient. Moreover, it is EBT eligible, making it accessible for purchase with SNAP benefits in select stores.

What We Like
Effective for colicky babies
Convenient online purchase
Improved baby's comfort
Cost-effective compared to others
Fast and consistent delivery
What We Don't Like
Unpleasant smell
Weird taste
#TOP 3

Nutricia Pepticate Baby Formula

NUTRICIA PEPTICATE
Nutricia Pepticate Baby Formula Cover
Pepticate Baby Formula, Hypoallergenic Powdered Infant Formula for Cow Milk Allergy, with Omega 3 DHA, ARA, Iron & Prebiotics, 13.2oz

Pepticate Formula is a hypoallergenic powdered infant formula by Nutricia Pepticate, designed for infants with cow milk allergy. It has over 30 years of experience managing cow milk allergy symptoms like eczema and colic. Inspired by breast milk, it contains prebiotic oligosaccharides for digestive health, nucleotides for the immune system, and DHA plus ARA for brain and eye development. Made in Europe, it's a safe and well-tolerated formula trusted in over 75 countries.

What We Like
Better taste than competitors
Effective for cow milk allergy
Improved digestion and comfort
High-quality ingredients
Positive customer support experience
What We Don't Like
Higher price point
Some ingredients could be better
#TOP 4

Enfamil Nutramigen Infant Formula, Lactose Free, 6 Liquid Bottles (4 Count)

Nutramigen
0529wl1085
White
Enfamil Nutramigen Infant Formula, Lactose Free, 6 Liquid Bottles (4 Count) Cover
Enfamil Nutramigen Baby Formula, Hypoallergenic and Lactose Free Formula with Enflora LGG, Fast Relief from Severe Crying and Colic, Ready to Use Bottle, 8 Fl Oz (24 Count) (Pack of 4)

The Enfamil Nutramigen Infant Formula is a lactose-free and hypoallergenic baby formula designed to provide fast relief from colic caused by cow's milk allergy. It includes LGG, a probiotic that helps manage allergies and supports digestion. Nutramigen also contains important nutrients like omega-3 DHA, ARA, and choline that provide brain and immune support for the baby. Clinically proven to provide relief as early as the first feeding, it helps the baby's immune system return to consuming traditional milk protein formula without an allergic response. Enfamil Nutramigen Infant Formula is the #1 trusted brand for brain-building and immune support, and is recommended by pediatricians.

What We Like
Great value on Amazon
Convenient ready-to-use bottles
Effective for milk allergy
Easy to transport
What We Don't Like
Unpleasant smell
Pricey product

Gerber Good Start Baby Formula Powder, Extensive HA

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Gerber Good Start Baby Formula Powder, Extensive HA Cover
Extensive HA® Hypoallergenic Infant Formula with Iron, DHA & Probiotics, 14.1 oz

Gerber Good Start Baby Formula Powder, Extensive HA is a hypoallergenic formula designed for babies with cow's milk protein allergies. It features 100% high-quality whey protein, broken down into tiny pieces to be well-tolerated. Gerber Good Start line is made to comfort your baby's tummy, and it includes a range of products from infant formula to baby food to snacks and toddler food. Gerber foods are made with whole ingredients like real fruits, veggies, and grains to provide wholesome options for your infant or toddler's nourishment.

What We Like
Improves discomfort and gas
Less bitter than other formulas
Easy to mix with warm water
Non-GMO and trusted brand
Normal bowel movements
What We Don't Like
Limited quantity per container
Availability in stores is low
#TOP 6

Enfamil Nutramigen Infant Formula

300871437012
Enfamil Nutramigen Infant Formula Cover
Enfamil Nutramigen Hypoallergenic Baby Formula with Iron, Lactose Free, Colic Relief from Cow's Milk Allergy Starts in 24 Hours, Brain Building DHA, Probiotic LGG for Immune Support, 2 Fl Oz, 48 Count

Enfamil Nutramigen Infant Formula is a hypoallergenic and lactose-free formula that helps ease colic and delivers fast relief from severe crying. It includes LGG, the most extensively studied probiotic for allergy management, and has important nutrients found in breast milk such as omega-3 DHA, ARA, and choline that provide brain support. It helps support baby's immune system to return to consuming traditional milk protein formula without an allergic response. Enfamil is the #1 Trusted Brand for Brain-building & Immune Support and is pediatrician recommended.

What We Like
Convenient for traveling
Helps reduce gas and colic
Allergy-friendly formula
No refrigeration needed
Easy to use
What We Don't Like
Pricey for small quantity
Requires separate nipple tops
#TOP 7

Neocate Syneo Infant Hypoallergenic Formula - 14.1 Oz Can

127049_UN
Neocate Syneo Infant Hypoallergenic Formula - 14.1 Oz Can Cover
Neocate Syneo Infant - Hypoallergenic, Dairy-Free, Amino Acid-Based Baby Formula with Prebiotic Fiber, Probiotics & DHA/ARA - Food Allergy-Friendly Formula - 14.1 oz (Pack of 1)

Neocate Syneo Infant is a dairy-free, hypoallergenic, amino-acid-based baby formula that is nutritionally complete for infants up to 12 months. It contains a patented blend of prebiotics and probiotics, nucleotides, and DHA/ARA to support normal growth and development of the brain and eyes. This formula is ideal for babies with allergies, colic, and other digestive issues, and is for use under medical supervision. Neocate Syneo Infant is the world's number 1 amino-acid-based formula brand, based on worldwide sales volume.

What We Like
Effective for allergies
Relieves colic
Helps with reflux
Improves sleep quality
Recommended by specialists
What We Don't Like
High cost
Strange taste
#TOP 8

Neocate Infant Hypoallergenic Baby Formula - 14.1 Oz Can (Pack of 4)

SB12595CA
Neocate Infant Hypoallergenic Baby Formula - 14.1 Oz Can (Pack of 4) Cover
Nutricia Neocate Infant - Hypoallergenic, Amino Acid-Based Baby Formula - Well-Tolerated & Supports Normal Growth - Infant Formula with DHA, ARA & Iron - 14.1 oz can (Pack of 4)

Neocate Infant is a dairy-free, soy oil-free, and hypoallergenic baby formula designed for infants with cow milk allergy and multiple food allergies. It contains nucleotides and DHA/ARA to support brain and eye development, and provides complete nutrition for infants aged 0-12 months. As a medical food, it requires supervision from a healthcare professional. Neocate Infant is the world's number one amino-acid-based formula brand, based on worldwide sales volume.

What We Like
Fast delivery
Helps babies with CMPA
Effective for picky eaters
Well-sealed and undamaged cans
Positive impact on infant's mood
What We Don't Like
Expensive
Contains synthetic ingredients
#TOP 9

PurAmino Infant Drink, for Severe Food Allergies, Omega-3 DHA, Iron, Powder Can

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PurAmino Infant Drink, for Severe Food Allergies, Omega-3 DHA, Iron, Powder Can Cover
PurAmino Hypoallergenic Infant Drink, for Severe Food Allergies, Omega-3 DHA, Iron, Immune Support, Powder Can, 14.1 Oz

PurAmino is a hypoallergenic infant formula suitable for both oral and tube feeding. It is designed for infants with severe cow's milk protein allergy and other conditions such as Eosinophilic esophagitis, short bowel syndrome and malabsorption. It can be the sole nutritional source for infants up to 6 months old and a supplemental nutrition source for up to 2 years old. With expert recommended DHA, it provides brain-building nutrition. PurAmino is a 100% amino-acid based, iron-fortified formula, suitable for infants and toddlers with lactose intolerance. Enfamil, the brand behind the product, is the #1 Trusted Brand for Brain-building & Immune Support, and #1 infant formula brand recommended by pediatricians.

What We Like
Effective for sensitive tummies
Improves weight gain
Easy to digest
Positive taste feedback
Helpful for bloody stools
What We Don't Like
Pricey formula
Insurance may not cover
#TOP 10

Enfamil Nutramigen Baby Formula, Hypoallergenic and Lactose Free Formula

123901
Gold and White Can
Enfamil Nutramigen Baby Formula, Hypoallergenic and Lactose Free Formula Cover
Enfamil Nutramigen Baby Formula, Hypoallergenic and Lactose Free Formula with Enflora LGG, Fast Relief from Severe Crying and Colic, Powder Can, 12.6 Oz (6 Count)

Enfamil Nutramigen Infant Formula is a hypoallergenic and lactose-free formula that is designed to provide fast relief from severe crying and colic. It contains clinically proven ingredients such as extensively hydrolyzed proteins, LGG probiotic, omega-3 DHA, ARA, and choline to provide brain support and immune system support. It is the #1 trusted brand recommended by pediatricians and is available in powder form. Customers are satisfied with the product, however, the price is too high and some customers have experienced damaged cans on delivery.

What We Like
Effective for milk allergies
Improves baby’s weight gain
Reduces gas and discomfort
Convenient online availability
What We Don't Like
Expensive compared to alternatives
Initial unpleasant smell
Buying Guide Image

Best Choices of Hypoallergenic Baby Formula for Babies

What is Hypoallergenic Baby Formula?

Hypoallergenic baby formula is a type of formula that is specifically designed for infants who have allergies or sensitivities to certain proteins found in regular infant formula. These formulas are made with proteins that have been extensively hydrolyzed, which means they have been broken down into smaller pieces. This makes it easier for babies to digest the formula and reduces the likelihood of an allergic reaction.

Why Choose Hypoallergenic Baby Formula?

Babies who have allergies or sensitivities to proteins in regular formula may experience symptoms such as vomiting, diarrhea, constipation, eczema, and gas. These symptoms can be uncomfortable and even painful for your baby. By choosing a hypoallergenic formula, you can help reduce the likelihood of these symptoms and provide your baby with the nutrition they need to grow and thrive.

How to Choose the Right Hypoallergenic Baby Formula

When choosing a hypoallergenic baby formula, there are a few key factors to consider. First and foremost, it's important to talk to your baby's doctor about their specific needs and allergies. Your doctor can provide guidance on which type of formula is best for your baby and any potential risks or concerns.

Once you have your doctor's recommendations, you can start looking for a formula that meets your baby's needs. Some key things to look for include:

  • Extensively hydrolyzed protein: As mentioned above, extensively hydrolyzed protein is key for reducing the likelihood of an allergic reaction. Make sure the formula you choose has this type of protein.

  • Non-GMO ingredients: Non-GMO ingredients are not genetically modified and are considered to be safer and more natural. Look for a formula that is made with non-GMO ingredients.

  • Organic: Organic formulas are made with ingredients that are grown without the use of synthetic pesticides, herbicides, and fertilizers. If you're concerned about the purity and quality of the ingredients in your baby's formula, look for an organic option.

  • Age-appropriate: As your baby grows and develops, their nutritional needs will change. Make sure the formula you choose is appropriate for your baby's age.

Conclusion

Choosing a hypoallergenic baby formula can be a challenging task, but it's important for the health and well-being of your little one. By considering your baby's specific needs and allergies, and looking for a formula with extensively hydrolyzed protein, non-GMO ingredients, and organic options, you can help ensure that your baby gets the nutrition they need without the risk of an allergic reaction.

Frequently Asked Questions (FAQs)

1. What is the difference between Alimentum and Nutramigen?

The main difference between Alimentum and Nutramigen is the type of sugars used. Nutramigen contains corn syrup, while Alimentum has corn maltodextrin. Corn syrup is higher in sugar content compared to maltodextrin. Both formulas do not contain artificial growth hormones.

2. Does hypoallergenic formula make babies gassy?

Hypoallergenic formulas are formulated with proteins that are broken down into easier-to-digest proteins, which can be beneficial for gassy babies. These specialized formulas contain different carbohydrates and proteins that may work better for babies who experience gassiness.

3. What is the disadvantage of hypoallergenic formula?

One disadvantage of hypoallergenic formula is the smell and taste. The milk proteins in these formulas are broken down into small peptides and individual amino acids, resulting in a bitter taste. However, babies often accept these formulas well despite the unappealing smell and taste.

4. How long does it take for baby to adjust to hypoallergenic formula?

While many babies have no issues switching formulas, it can take 3 to 5 days for babies to become used to a new formula, especially hypoallergenic formulas. These formulas may have a different smell and taste, which can require some adjustment for the baby.

5. Do babies poop more on hypoallergenic formula?

In general, babies tend to poop less often on hypoallergenic amino acid-based formulas. These formulas are designed to be easily absorbed by the baby's digestive system, and they do not contain fiber. As a result, babies may have fewer bowel movements when on hypoallergenic formulas.

Editor's Notes

During our hypoallergenic baby formula research, we found 24 hypoallergenic baby formula products and shortlisted 10 quality products. We collected and analyzed 62,501 customer reviews through our big data system to write the hypoallergenic baby formula list. We found that most customers choose hypoallergenic baby formula with an average price of $35.07.

The hypoallergenic baby formula are available for purchase. We have researched hundreds of brands and picked the top brands of hypoallergenic baby formula, including Enfamil, Similac, NUTRICIA PEPTICATE, Nutramigen, Gerber. The seller of top 1 product has received honest feedback from 385 consumers with an average rating of 4.7.

Written by
Elisa Drew Avatar

Elisa Drew is a really professional copywriter specializing in baby products with five years of experience working as a pediatrician once. She has published a series of baby books purchased by over thirty thousand people in the United States.

Hypoallergenic Baby Formula Comparison Table

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Brand Enfamil Similac NUTRICIA PEPTICATE Nutramigen Gerber Enfamil Neocate Neocate Enfamil Enfamil
Item Form Powder Powder Powder Liquid - Powder Powder Powder Powder Powder
Size 27.8 Ounce (Pack of 1) 19.8 Ounce (Pack of 1) 13.2 Ounce (Pack of 1) 48 Fl Oz (Pack of 4) - 12 Fl Oz (Pack of 8) - 14.1 Ounce (Pack of 4) 14.1 Ounce (Pack of 1) 12.6 Ounce (Pack of 6)
Manufacturer recommended age 0 - 10 months - - - 0 - 10 months 0 - 10 months 0 - 1 years - 0 - 2 years 0 - 2 months
Item Weight 27.8 Ounces - 1 Pounds - - 10.62 Pounds - 503.7 Grams 14.2 Ounces 0.86 Pounds
Allergen Information Milk Soy, Milk - - - Hypoallergenic - - Milk Milk
FTB Score
ftb score rating icon 9.8
ftb score rating icon 9.7
ftb score rating icon 9.5
ftb score rating icon 9.4
ftb score rating icon 9.2
ftb score rating icon 9.0
ftb score rating icon 8.8
ftb score rating icon 8.6
ftb score rating icon 8.5
ftb score rating icon 8.3
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