Best Baby Formula for Colic of 2026

Elisa Drew Avatar
Elisa Drew
Last Updated: Jan 19, 2026

* We independently evaluate all recommended products and services. If you click on links we provide, we may receive compensation.

If your baby is suffering from colic, finding the right formula can make all the difference. There are a variety of baby formulas on the market that are designed to ease colic symptoms and provide relief for both baby and parents. Some popular options include Enfamil Gentlease, Similac Sensitive, and Gerber Good Start Soothe. These formulas are specially designed with gentle, easy-to-digest proteins and prebiotics to help soothe a baby's digestive system and reduce fussiness and gas. Always consult with your pediatrician before making any changes to your baby's diet.

At a Glance: Our Top Picks

Enfamil Nutramigen Hypoallergenic Formula Cover #TOP 1
Enfamil Nutramigen Hypoallergenic Formula
ftb score rating icon 9.8
Enfamil Nutramigen Hypoallergenic Baby Formula Cover #TOP 2
Enfamil Nutramigen Hypoallergenic Baby Formula
ftb score rating icon 9.7
Similac Alimentum Infant Formula Cover #TOP 3
Similac Alimentum Infant Formula
ftb score rating icon 9.5

Top 9 Baby Formula for Colic

Enfamil Nutramigen Hypoallergenic Formula

Enf-9533
White
Enfamil Nutramigen Hypoallergenic Formula Cover
Enfamil Nutramigen Hypoallergenic Baby Formula with Iron, Lactose Free, Colic Relief from Cow's Milk Allergy Starts in 24 Hours, Brain Building DHA, Probiotic LGG for Immune Support, 19.8 Oz Can

Enfamil Nutramigen Formula is designed to help ease your baby's colic caused by cow's milk allergies. It provides gentle relief, often reducing excessive crying in less than a day, making for a happier baby and a more restful parent. This formula features LGG probiotic, which supports your baby's digestive health, ensuring they feel their best. Additionally, it's hypoallergenic with hydrolyzed proteins, minimizing the risk of allergic reactions, and it's lactose-free, perfect for babies with lactose intolerance. With Nutramigen, you can feel confident knowing you're giving your little one a soothing solution.

What We Like
Effective for reflux
Relieves digestive issues
Helps milk protein allergy
No constipation
Improves baby's comfort

Enfamil Nutramigen Hypoallergenic Baby Formula

Enfamil Nutramigen Hypoallergenic Baby Formula Cover
Enfamil Nutramigen Hypoallergenic Baby Formula with Iron, Lactose Free, Colic Relief from Cow's Milk Allergy Starts in 24 Hours, Brain Building DHA, Probiotic LGG for Immune Support, 27.8 Oz Can

Enfamil Nutramigen Formula is a gentle, lactose-free powder baby formula designed to help ease your little one's colic, providing fast relief within 48 hours. It features the superstar LGG probiotic, supporting your baby's digestive health. With nourishing brain development components like omega-3 DHA and ARA, it aids in your baby's brain growth. Additionally, it offers immunity support, helping your baby adapt to standard milk formula. Trusted by pediatricians, this formula is a top choice for managing cow's milk allergy, ensuring a happier, better-rested baby and mom.

What We Like
Relieves dairy allergy symptoms
Improves baby comfort and health
Effective for colic and allergies
High product quality
Best available deal

Similac Alimentum Infant Formula

Similac Alimentum Infant Formula Cover
Similac Alimentum With 2'-FL HMO Hypoallergenic Infant Formula, for Food Allergies and Colic Due to Protein Sensitivity, Baby Formula Powder, 19.8-oz Value Can

Similac Alimentum Formula by Similac is a hypoallergenic powder baby formula designed for infants with food allergies and colic. It contains a special milk protein that helps reduce allergic reactions in babies sensitive to cow's milk protein. This formula starts alleviating colic symptoms within 24 hours for most babies. Additionally, it is the first formula to include 2'-FL HMO, an immune-nourishing ingredient. Moreover, it is EBT eligible, making it accessible for purchase with SNAP benefits in select stores.

What We Like
Hypoallergenic formula
Relieves tummy troubles
Supports growth and health
Convenient ready-to-feed bottles
Easy on sensitive stomachs

Similac Alimentum Hypoallergenic Formula

57508
Similac Alimentum Hypoallergenic Formula Cover
Similac Alimentum with 2'-FL HMO Hypoallergenic Infant Formula, for Food Allergies and Colic Due to Protein Sensitivity, Ready-to-Feed Baby Formula, 8-fl-oz Bottle, Pack of 24

Similac Hypoallergenic Formula is designed for babies with food allergies and colic. It features a specially processed milk protein that minimizes the risk of allergic reactions for those sensitive to cow's milk. Most infants experience relief from colic symptoms within just 24 hours of use. Additionally, this formula includes 2'-FL HMO, an ingredient that supports your baby's immune health. As the top infant formula brand used in hospitals, you can trust its quality and effectiveness. Plus, you can earn rewards points by scanning the MySimilac QR code on select products, adding extra value to your purchase.

What We Like
Effective for dairy allergies
Reduces colic and reflux
Improves baby sleep and comfort
Convenient ready-to-feed packaging
Supports healthy weight gain
#TOP 5

Nutricia Pepticate Baby Formula

NUTRICIA PEPTICATE
Nutricia Pepticate Baby Formula Cover
Pepticate Baby Formula, Hypoallergenic Powdered Infant Formula for Cow Milk Allergy, with Omega 3 DHA, ARA, Iron & Prebiotics, 13.2oz

Pepticate Formula is a hypoallergenic powdered infant formula by Nutricia Pepticate, designed for infants with cow milk allergy. It has over 30 years of experience managing cow milk allergy symptoms like eczema and colic. Inspired by breast milk, it contains prebiotic oligosaccharides for digestive health, nucleotides for the immune system, and DHA plus ARA for brain and eye development. Made in Europe, it's a safe and well-tolerated formula trusted in over 75 countries.

What We Like
Great for sensitive stomachs
No bad taste or smell
Helps with allergies and eczema
Reduces spit-up and GI issues
Easy single ounce measurement
#TOP 6

Enfamil Nutramigen Infant Formula, Lactose Free, 6 Liquid Bottles (4 Count)

0529wl1085
White
Enfamil Nutramigen Infant Formula, Lactose Free, 6 Liquid Bottles (4 Count) Cover
Enfamil Nutramigen Hypoallergenic Baby Formula with Iron, Lactose Free, Colic Relief from Cow's Milk Allergy Starts in 24 Hours, Brain Building DHA, Concentrated Liquid, 8 Fl Oz, 24 Bottles

The Enfamil Nutramigen Infant Formula is a lactose-free and hypoallergenic baby formula designed to provide fast relief from colic caused by cow's milk allergy. It includes LGG, a probiotic that helps manage allergies and supports digestion. Nutramigen also contains important nutrients like omega-3 DHA, ARA, and choline that provide brain and immune support for the baby. Clinically proven to provide relief as early as the first feeding, it helps the baby's immune system return to consuming traditional milk protein formula without an allergic response. Enfamil Nutramigen Infant Formula is the #1 trusted brand for brain-building and immune support, and is recommended by pediatricians.

What We Like
Soothes colic and fussiness
Improves digestion and bowel movements
Suitable for milk protein allergy
Supports healthy growth
Convenient subscription savings
#TOP 7

Similac Alimentum With 2'-FL HMO Hypoallergenic Infant Formula

57512
Purple
Similac Alimentum With 2'-FL HMO Hypoallergenic Infant Formula Cover
Similac Alimentum With 2'-FL HMO Hypoallergenic Infant Formula, for Food Allergies and Colic Due to Protein Sensitivity, Ready-to-Feed Baby Formula, 32-fl-oz Bottle, Pack of 6

Similac Alimentum with 2’-FL HMO Hypoallergenic Infant Formula is designed to be easy to digest for babies with food allergies or colic due to protein sensitivity. It is the first and only hypoallergenic formula with 2 -FL HMO, an immune-nourishing ingredient. It is eligible to be purchased with Supplemental Nutrition Assistance Program (SNAP) benefits in select stores. Customers have found it to be helpful in reducing colic symptoms due to protein sensitivity within 24 hours in most infants, as well as being suitable for lactose sensitivity. It has been found to be convenient and cost-effective when used with Subscribe and Save, and has been successful in helping babies to gain weight and be healthy.

What We Like
Effective for colic relief
Convenient delivery options
Positive baby response
Cost-effective compared to stores
Easy to use ready-to-feed formula
#TOP 8

Enfamil Nutramigen Hypoallergenic Baby Formula

300871239418
1 Can (12.6 oz)
Enfamil Nutramigen Hypoallergenic Baby Formula Cover
Enfamil Nutramigen Hypoallergenic Baby Formula with Iron, Lactose Free, Colic Relief from Cow's Milk Allergy Starts in 24 Hours, Brain Building DHA, Probiotic LGG for Immune Support, 12.6 Oz Can

Enfamil Nutramigen Formula offers fast relief for babies with cow's milk allergy, helping you see improvements as soon as the first feeding. It’s designed to ease colic symptoms quickly, with most infants showing progress within two days, making feeding times less stressful for you and your baby. This formula also supports long-term health by reducing the chances of future allergy problems, giving you peace of mind. Plus, it helps your baby gradually tolerate milk protein again without an allergic reaction, which can make feeding easier over time.

What We Like
Relieves acid reflux symptoms
Helps with milk allergy
Reduces fussiness and crying
Quick and noticeable results
Gentle on sensitive stomachs
#TOP 9

Enfamil Nutramigen Infant Formula, Hypoallergenic and Lactose-Free Formula

VC-a3-42132
Enfamil Nutramigen Infant Formula, Hypoallergenic and Lactose-Free Formula Cover
Enfamil Nutramigen Hypoallergenic Baby Formula with Iron, Lactose Free, Colic Relief from Cow's Milk Allergy Starts in 24 Hours, Brain Building DHA, Probiotic LGG for Immune Support, 27.8 Oz, 4 Count

Enfamil Nutramigen is a lactose-free baby formula that helps ease colic and provides fast relief. It includes LGG, an extensively studied probiotic for allergy management and supports the digestive health of your baby. Additionally, Nutramigen has important nutrients found in breast milk such as omega-3 DHA, ARA, and choline that provide brain support and helps support the baby's immune system to return to consuming traditional milk protein formula without an allergic response. Enfamil is the #1 Trusted Brand for Brain-building & Immune Support and is pediatrician recommended.

What We Like
Effective for dairy allergies
Relieves colic symptoms
Improves baby's well-being
Best deal for quantity
Buying Guide Image

Frequently Asked Questions (FAQs)

1. What formula is best for colic baby?

Best baby formulas. Best baby formula for colic: Gerber Good Start SoothePro Powder Infant Fomula.Best baby formula for reflux: Enfamil A.R. Infant Formula.Best baby formula for gas: Enfamil Gentlease Infant Formula.Best baby formula for constipation: Enfamil Reguline Infant Formula.

2. Which milk is best for colic?

Goat milk formula is being anecdotally recommended by families who have switched their baby to goat milk based formula and seen an improvement in their baby's colic symptoms. This may have something to do with the fact that there is no added whey in the formula and it also has a lower lactose content.

3. Should I change formula if baby has colic?

Switching from a cow's milk formula to a hydrolyzed formula that's gentler on a baby's tummy has been recommended by the American Academy of Pediatrics for babies with colic. The AAP said parents could try a two-week trial of hydrolyzed formula to see if the gentler formula helps calm their baby.

4. Can babies get colic from formula?

Bottle feeding too fast (less than 20 minutes) or giving too much formula can trigger colic episodes.

Editor's Notes

During our baby formula for colic research, we found 24 baby formula for colic products and shortlisted 9 quality products. We collected and analyzed 131,865 customer reviews through our big data system to write the baby formula for colic list. We found that most customers choose baby formula for colic with an average price of $40.31.

The baby formula for colic are available for purchase. We have researched hundreds of brands and picked the top brands of baby formula for colic, including Enfamil, Similac, NUTRICIA PEPTICATE. The seller of top 1 product has received honest feedback from 384 consumers with an average rating of 4.7.

Written by
Elisa Drew Avatar

Elisa Drew is a really professional copywriter specializing in baby products with five years of experience working as a pediatrician once. She has published a series of baby books purchased by over thirty thousand people in the United States.