Best Prescription Horse Medications of 2026

Janie Foster Avatar
Janie Foster
Last Updated: Jan 8, 2026

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Prescription horse medications play a crucial role in maintaining equine health, addressing conditions ranging from infections to chronic diseases. These medications, prescribed by veterinarians, ensure targeted treatment tailored to each horse’s specific needs. Common types include antibiotics, anti-inflammatories, and dewormers, all designed to promote recovery and prevent complications. Proper administration and dosage are essential for effectiveness and safety, highlighting the importance of professional guidance in managing a horse’s medical care.

At a Glance: Our Top Picks

Dorzolamide 2% Ophthalmic Solution, Generic Cover #TOP 1
Dorzolamide 2% Ophthalmic Solution, Generic
ftb score rating icon 9.8
Generic Hydroxyzine HCl 10 mg Tablets for Animals Cover #TOP 2
Generic Hydroxyzine HCl 10 mg Tablets for Animals
ftb score rating icon 9.7
Generic Hydroxyzine HCl 50 mg Tablets for Animals Cover #TOP 3
Generic Hydroxyzine HCl 50 mg Tablets for Animals
ftb score rating icon 9.5

Top 10 Prescription Horse Medications

Dorzolamide 2% Ophthalmic Solution, Generic

Generic
GEN00068EA
Dorzolamide 2% Ophthalmic Solution, Generic Cover
Dorzolamide Ophthalmic Solution for Animals, 2%, 10 mL Bottle

Generic Dorzolamide Eye Drops are a sterile solution designed to help reduce high eye pressure in dogs, cats, and horses, making it useful for managing glaucoma. You can use this medication by itself or combine it with other treatments to better control your pet’s eye condition. If your animal has a sulfa drug allergy, you should be cautious when using this product to avoid any adverse reactions. Although not approved by the FDA for all animals, veterinarians commonly prescribe it for various species, so be sure to check with your vet to see if it’s right for your pet.

What We Like
Reduces intraocular pressure
Works for multiple species
Can be combined with other meds
Suitable for glaucoma treatment
#TOP 2

Generic Hydroxyzine HCl 10 mg Tablets for Animals

Generic
GEN00070BO
10 mg
Generic Hydroxyzine HCl 10 mg Tablets for Animals Cover
Hydroxyzine HCl Tablets for Animals, 10 mg, 100 Tablets

Generic Hydroxyzine Animal Tablets are designed to help manage itching caused by conditions like atopic dermatitis, hives, and insect bites in dogs, cats, and horses. This can bring relief to your pets by reducing their discomfort and improving their quality of life. Additionally, these tablets can serve as a mild sedative for small animals, helping to calm them when needed. However, it’s important to avoid using this medication if your pet has an enlarged prostate, urinary or digestive blockages, or severe heart problems. Always consult your veterinarian to ensure this medication is safe and appropriate for your animal’s specific needs.

What We Like
Itch relief
Mild sedation
Multi-species use
Veterinarian prescribed
#TOP 3

Generic Hydroxyzine HCl 50 mg Tablets for Animals

Generic
GEN00074BO
50 mg
Generic Hydroxyzine HCl 50 mg Tablets for Animals Cover
Hydroxyzine HCl Tablets for Animals, 50 mg, 500 Tablets

Generic Hydroxyzine 50 mg is designed to help manage itching in pets such as dogs, cats, and horses. If your animal suffers from conditions like atopic dermatitis, hives, or reactions to insect bites, this medication can provide relief and improve their comfort. It also works as a mild sedative for smaller animals, which can be useful during stressful situations or vet visits. However, it’s important to avoid using this product if your animal has certain health issues like an enlarged prostate, blockages in the urinary or digestive systems, or severe heart problems. Always check with your veterinarian to ensure it’s safe and appropriate for your pet.

What We Like
Itch relief for pets
Mild sedation for small animals
Supports treatment of skin conditions
Veterinarian-approved use
#TOP 4

Methocarbamol 500 mg Tablets for Animals

Generic
GEN00082BO
500 mg
Methocarbamol 500 mg Tablets for Animals Cover
Methocarbamol Tablets for Animals, 500 mg, 500 Tablets

Generic Methocarbamol Animal Tablets are designed to help relieve muscle spasms in pets like dogs, cats, and horses, which can occur from injuries, inflammation, or surgery. This makes recovery more comfortable for your animals. The tablets also help relax muscles and reduce shaking caused by other health issues, such as spinal problems, tetanus, or reactions to certain drugs. However, these tablets should not be used for animals raised for food. If you have other types of pets, consult your vet before using this medication to ensure it’s safe and appropriate for your animal’s specific needs.

What We Like
Muscle spasm relief
Muscle relaxation
Treats tremors
Suitable for multiple animals
#TOP 5

Dormosedan Gel Oral Sedative for Horses

Dormosedan
23141306SY
3 mL
Dormosedan Gel Oral Sedative for Horses Cover
Dormosedan Gel (detomidine Hydrochloride) for Horses, 3 mL

Dormosedan Oral Sedative is a gentle and easy-to-use solution designed to help you manage your horse during routine care. It works as a mild sedative to keep your horse calm during non-painful procedures like hoof trimming or grooming. Since it’s an oral medication prescribed by veterinarians, you can safely give it yourself, making horse care less stressful for both you and your animal. The sedative comes in a convenient single-dose syringe that you place under your horse’s tongue, so there’s no need for needles. It starts working within about 40 minutes, helping ensure a smooth and safer experience.

What We Like
Mild standing sedation
Oral, needle-free use
Veterinarian prescribed
Quick, reliable effect
#TOP 6

Majesty's PillEase Pliable Pill Wrap Treats

638402600353
Majesty's PillEase Pliable Pill Wrap Treats Cover
Majesty's PillEase Horse Treats | A Delicious Soft and Pliable No Bake Cookie Horse Treat | Makes Giving Pills & Medication Easy | Made in The USA - 48 Wafers

Majesty's PillEase Pill Treats are designed to make giving your horse medication easier and more pleasant. These soft, no-bake cookies are pliable, so you can break them into smaller pieces to fit different pill sizes or your horse's preferences. They contain ingredients like lecithin, pectin, and coconut oil that support your horse's digestive health. Plus, you can use them as everyday treats to help your horse get used to the taste without associating the treat only with medicine. This makes the process smoother and less stressful for both you and your horse.

What We Like
Soft and pliable texture
Easy pill hiding
Horses enjoy the taste
Can split into smaller pieces
Resealable, fresh bag
What We Don't Like
Some crumbling for few users
Higher price point
#TOP 7

Majesty's PillEase Pliable Pill Wrap Treats

638402600353
6 Pound (Pack of 2)
Majesty's PillEase Pliable Pill Wrap Treats Cover
Majesty's PillEase Horse Treats | Pack of Two 48 Ounces Each |Makes Giving Medication Easy | Made in The USA | A Delicious Soft and Pliable No Bake Cookie Horse Treat

Majesty's PillEase Horse Treats make giving your horse medication much easier by wrapping pills in a soft, tasty treat. Each package includes two bags, so you have plenty on hand for daily use or special medication times. These treats contain ingredients like lecithin, pectin, and coconut oil, which support your horse’s digestive health. You can also use them as regular treats, helping your horse get used to the taste without associating them only with medicine. Plus, the treats are soft and pliable, so you can break them to fit the size of the pill or your horse’s preference, making medication time less stressful for both of you.

What We Like
Soft and pliable texture
Easy pill concealment
Horses enjoy the taste
Can split for multiple uses
Resealable, fresh bag
What We Don't Like
Can be a bit pricey
Occasional crumbling

Horse Health ivermectin paste

100503595
Green
0.21 Ounces
Horse Health ivermectin paste Cover
Horse Health (ivermectin paste) 1.87%, Equine Dewormer, up to 1,250 lbs 0.21 Ounces

Horse Health Dewormer is a highly effective treatment for a variety of parasites in horses. With just one dose, it can remove worms and bots, providing thorough treatment and control. The apple-flavored paste makes it easy to administer, ensuring that your horse will take it without any fuss. This dewormer is safe and effective for all horses, including broodmares, stallions, and foals. It is specially formulated to target and eliminate large and small strongyles, pinworms, ascarids, hairworms, large-mouth stomach worms, bots, lungworms, intestinal threadworms, and summer sores caused by third-stage larvae. Keep your horse healthy and protected with Horse Health Dewormer.

What We Like
Easy administration
Clear dosage markings
Effective deworming
Affordable price
No strong smell
What We Don't Like
Unpleasant taste
Small tube size
#TOP 9

EZY DOSE Weekly AM/PM Pill Organizer

67376
Color May Vary
3X-Large
EZY DOSE Weekly AM/PM Pill Organizer Cover
EZY DOSE Weekly (7-Day) AM/PM Pill Planner, Medicine Case, Vitamin Organizer Box, 3X-Large Locking Compartments to Secure Prescription Medication, Prevent Accidental Spilling, Color May Vary, BPA Free

The EZY DOSE Pill Organizer is designed to help you manage your daily medications with ease. It features 14 compartments for morning and evening doses over a full week, making it simple to keep track of your pills. Each compartment has a locking lid to prevent spills and protect your medicine, which is especially helpful if you have trouble opening containers. The organizer can hold up to 100 aspirin-sized pills, giving you plenty of space for vitamins and supplements. Made from durable, BPA-free plastic, it’s built to last and perfect for both home use and travel.

What We Like
Secure locking mechanism
Large compartment capacity
Easy to open with button
Multiple color options
Fits many large supplements
What We Don't Like
Locking feature may loosen
Box size may be bulky
#TOP 10

EZY DOSE 14-Day AM/PM Pill Organizer

67828
Color May Vary
2X-Large
EZY DOSE 14-Day AM/PM Pill Organizer Cover
EZY DOSE (14-Day) AM/PM Pill Planner, Medicine Case, Vitamin Organizer Box, 2X-Large Locking Compartments to Secure Prescription Medication and Prevent Accidental Spilling, Color May Vary, BPA Free

The EZY DOSE Pill Planner is a convenient weekly pill organizer designed to help you easily manage your daily medication. It features locking compartments that keep your pills secure and prevent accidental spills, so you can trust your medication stays safe. Each compartment can hold up to 20 aspirin-sized pills, giving you plenty of space for your daily doses. Plus, it’s built with durable materials to withstand frequent use, ensuring it lasts as long as you need it. This pill planner makes organizing your medication simple and reliable, helping you stay on track with your health routine.

What We Like
Large compartments
Secure locking mechanism
Easy to open and close
Durable build quality
Accidental spill prevention
What We Don't Like
Text fades over time
Bulky for travel
Buying Guide Image
Editor's Notes

During our prescription horse medication research, we found 23 prescription horse medication products and shortlisted 10 quality products. We collected and analyzed 19,779 customer reviews through our big data system to write the prescription horse medications list. We found that most customers choose prescription horse medications with an average price of $28.21.

The prescription horse medications are available for purchase. We have researched hundreds of brands and picked the top brands of prescription horse medications, including Dormosedan, Majesty's, Horse Health, EZY DOSE. The seller of top 1 product has received honest feedback from 903 consumers with an average rating of 4.7.

Written by
Janie Foster Avatar

Janie Foster is a writer & pet blogger from Los Angeles, she enjoys living with her two cats and three dogs. She owned her first dog 10 years ago and then started her personal blog to record her dog's daily life. Throughout her personal life, she has developed specialized knowledge in pet care, pet nutrition, feeding habits, and more.

Prescription Horse Medications Comparison Table

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Brand Generic Generic Generic Generic Dormosedan Majesty's Majesty's Horse Health EZY DOSE EZY DOSE
Brand Name Generic Generic Generic Generic Dormosedan Majesty's Majesty's Horse Health - -
Target Audience Keyword Cats, Dogs, Horses Cats, Dogs, Horses Cats, Dogs, Horses Cats, Dogs, Horses Horses horses horses horses - -
Size 2% 10 mg 50 mg 500 mg 3 mL 3 Pounds (Pack of 1) 6 Pound (Pack of 2) 0.21 Ounces - -
Specific Uses for Product Eyes Coat Coat Pain Pain Training, Aid in administering medicine Behavior Parasites - -
Directions Dorzolamide Ophthalmic Solution should be applied as directed by your veterinarian. Please consult your veterinarian before making any changes to the prescribed dosing schedule. Hydroxyzine should be given orally as directed by your veterinarian. Please consult your veterinarian before making any changes or discontinuing the prescribed dosing schedule. Hydroxyzine should be given orally as directed by your veterinarian. Please consult your veterinarian before making any changes or discontinuing the prescribed dosing schedule. Methocarbamol tablets should be given orally as directed by your veterinarian. Please consult your veterinarian before making any changes or discontinuing the prescribed dosing schedule. 1. Dosage and Administration: DORMOSEDAN GEL is administered sublingually at 0.018 mg/lb(0.040 mg/kg). 2. For the best results, allow adequate time (a minimum of 40 minutes) between administration of DORMOSEDAN GEL and beginning the procedure. In general, horses show sedative effects lasting approximately 90-180 minutes. Use as directed for administering medication: 1. Break the PillEase treat in half. 2. Place the pill in the middle of the treat. 3. Fold the treat around the pill. 4. Feed the treat to the horse. For everyday use: 1. Feed the treat to the horse as is. To use these treats, form them around the medication to make it easier to give to the horse. - - -
Model Name Dorzo Ophthalmic Solution for Animals Hydroxyzine HCl Tablets for Animals Hydroxyzine HCl Tablets for Animals Metho Tablets for Animals Dormosedan Gel (detomidine hydrochloride) for Horses, 3 mL - - (ivermectin paste) 1.87%, Equine Dewormer, up to 1,250 lbs - -
FTB Score
ftb score rating icon 9.8
ftb score rating icon 9.7
ftb score rating icon 9.5
ftb score rating icon 9.3
ftb score rating icon 9.1
ftb score rating icon 9.0
ftb score rating icon 8.8
ftb score rating icon 8.8
ftb score rating icon 8.6
ftb score rating icon 8.5
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