Best Prescription Cat Medications of 2026

Janie Foster Avatar
Janie Foster
Last Updated: Jan 8, 2026

* We independently evaluate all recommended products and services. If you click on links we provide, we may receive compensation.

Prescription cat medications are specially formulated treatments designed to address a variety of feline health issues, from infections and allergies to chronic conditions like arthritis or diabetes. These medications often require a veterinarian’s approval and careful dosage to ensure safety and effectiveness. They come in various forms, including tablets, liquids, and topical applications, making administration easier for pet owners. Proper use of prescription meds can significantly improve a cat’s quality of life and overall well-being.

At a Glance: Our Top Picks

Methimazole 5 mg Tablets for Cats, 100 Count Cover #TOP 1
Methimazole 5 mg Tablets for Cats, 100 Count
ftb score rating icon 9.9
Onsior 6mg Cat Pain Relief Tablets Cover #TOP 2
Onsior 6mg Cat Pain Relief Tablets
ftb score rating icon 9.8
Droncit Cat Tapeworm Tablets 23 mg Cover #TOP 3
Droncit Cat Tapeworm Tablets 23 mg
ftb score rating icon 9.6

Top 10 Prescription Cat Medications

#TOP 1

Methimazole 5 mg Tablets for Cats, 100 Count

Generic
GEN00029BO
100 Tablets
Methimazole 5 mg Tablets for Cats, 100 Count Cover
Methimazole Tablets for Animals, 5 mg, 100 Tablets

Generic Methimazole Cat Tablets are designed to help manage hyperthyroidism, a condition where your cat’s thyroid gland is overactive. This medication can improve your cat's quality of life by controlling symptoms, though it doesn’t cure the condition. It’s important to follow your veterinarian’s instructions carefully and keep all follow-up visits and blood tests to ensure the treatment is working well. If you’re pregnant, nursing, or planning to become pregnant, avoid handling the tablets or wear gloves for safety. While mainly used for cats, your vet might also prescribe this medicine for other animals based on their needs.

What We Like
Affordable price
Easy ordering process
Vet cost savings
What We Don't Like
Hard to split pills
No score mark
#TOP 2

Onsior 6mg Cat Pain Relief Tablets

21860840PG
Blue
Onsior 6mg Cat Pain Relief Tablets Cover
Onsior Tablets for Cats, 3 Doses 6mg

Onsior Cat Pain Tablets provide a simple way to ease your cat's discomfort after surgery. These small, tasty tablets are designed for once-a-day use, making it easy to give your cat the right dose for up to three days. They are especially helpful after procedures like orthopedic surgery or spaying and neutering, helping your pet recover more comfortably at home. As the only FDA-approved oral NSAID for cats, Onsior offers a trusted option for managing your cat's pain safely. Always consult your veterinarian to see if Onsior is the right choice for your feline friend.

What We Like
Fast delivery
Quick symptom relief
Improved sleep for baby
#TOP 3

Droncit Cat Tapeworm Tablets 23 mg

28182999PD
23mg
Droncit Cat Tapeworm Tablets 23 mg Cover
Droncit Tablets for Cats, 2 Tablets 23 mg

Droncit Cat Tapeworm Tablets offer an easy solution to get rid of common tapeworms in your cat or kitten. These tablets effectively target tapeworms caused by fleas, helping to keep your pet healthy. The single-dose design means you only need to give one tablet, making treatment simple and quick. If your cat is picky, you can crumble the tablet and mix it with their food, making it easier to administer. Overall, this product provides a convenient and effective way to protect your cat from tapeworm infections.

What We Like
Effective tapeworm removal
Targets flea-transmitted tapeworms
Single-dose convenience
Can mix with food
#TOP 4

Clavamox Oral Suspension Drops for Pets

23008016BO
15mL
Clavamox Oral Suspension Drops for Pets Cover
Clavamox (amoxicillin and clavulanate Potassium for Oral Suspension) Drops for Dogs & Cats, 15 mL

The Clavamox Oral Drops provide a liquid prescription treatment designed to help dogs and cats fight bacterial infections like skin issues, soft tissue infections, and urinary tract problems. This easy-to-use formula makes giving medicine simpler for you and less stressful for your pet. Vets appreciate it for its convenience, making it a trusted option for many pet owners. Administer the drops every 12 hours as directed by your vet, ensuring your furry friend gets the full course of treatment needed to recover effectively.

What We Like
Easy-to-use liquid formula
Effective for multiple infections
Trusted by veterinarians
Twice-daily dosing
#TOP 5

Revolution Plus Topical Solution for Cats

087219130735
Orange
5.6-11 lbs
Revolution Plus Topical Solution for Cats Cover
Revolution Plus (selamectin and sarolaner Topical Solution) for Cats, 5.6-11 lbs (Orange), 3 Tubes

Revolution Plus Cat Treatment offers a simple, once-a-month topical solution to keep your cat safe from a wide range of parasites. It protects against fleas, ticks, ear mites, and several types of worms, including heartworms, which can be serious health threats. This makes it a convenient all-in-one option to help you avoid multiple treatments. Trusted by veterinarians for over 25 years, it’s a reliable choice for cats and kittens older than eight weeks and weighing at least 2.8 pounds. Whether your cat stays indoors or goes outside, this treatment helps protect them from parasites they might encounter anywhere.

What We Like
Easy application
No skin irritation
Comprehensive parasite protection
Vet recommended
Online availability
What We Don't Like
Prescription required
Higher cost
#TOP 6

Generic Hydroxyzine HCl 10 mg Tablets for Animals

Generic
GEN00070BO
10 mg
Generic Hydroxyzine HCl 10 mg Tablets for Animals Cover
Hydroxyzine HCl Tablets for Animals, 10 mg, 100 Tablets

Generic Hydroxyzine Animal Tablets are designed to help manage itching caused by conditions like atopic dermatitis, hives, and insect bites in dogs, cats, and horses. This can bring relief to your pets by reducing their discomfort and improving their quality of life. Additionally, these tablets can serve as a mild sedative for small animals, helping to calm them when needed. However, it’s important to avoid using this medication if your pet has an enlarged prostate, urinary or digestive blockages, or severe heart problems. Always consult your veterinarian to ensure this medication is safe and appropriate for your animal’s specific needs.

What We Like
Itch relief
Mild sedation
Multi-species use
Veterinarian prescribed
#TOP 7

Dorzolamide 2% Ophthalmic Solution, Generic

Generic
GEN00068EA
Dorzolamide 2% Ophthalmic Solution, Generic Cover
Dorzolamide Ophthalmic Solution for Animals, 2%, 10 mL Bottle

Generic Dorzolamide Eye Drops are a sterile solution designed to help reduce high eye pressure in dogs, cats, and horses, making it useful for managing glaucoma. You can use this medication by itself or combine it with other treatments to better control your pet’s eye condition. If your animal has a sulfa drug allergy, you should be cautious when using this product to avoid any adverse reactions. Although not approved by the FDA for all animals, veterinarians commonly prescribe it for various species, so be sure to check with your vet to see if it’s right for your pet.

What We Like
Reduces intraocular pressure
Works for multiple species
Can be combined with other meds
Suitable for glaucoma treatment
#TOP 8

Elura Capromorelin Oral Solution 20 mg/ml

Elura
21056402EA
15mL
Elura Capromorelin Oral Solution 20 mg/ml Cover
Elura Capromorelin Oral Solution for Cats | 20 mg/ml, 15 ml

The Elura Cat Weight Solution is a once-daily oral liquid designed to help cats with chronic kidney disease (CKD) maintain or gain weight. This medication is unique as it is the only approved treatment specifically for managing weight loss in cats with CKD, giving you a trusted option for your pet's health. The flavored formula makes it easier to give your cat the medicine directly by mouth, which can simplify daily dosing. After giving Elura, you should offer food about 30 minutes later to support your cat’s appetite and nutrition. Always consult your vet to see if this treatment suits your cat.

What We Like
appetite stimulation
weight gain support
muscle building aid
effective for illness-related appetite loss
can be prescribed for dogs
What We Don't Like
not available as ear gel
#TOP 9

Revolution Plus Topical Solution for Cats 2.8-5.5 lbs

10020413
Gold
2.8-5.5 lbs
Revolution Plus Topical Solution for Cats 2.8-5.5 lbs Cover
Revolution Plus (selamectin and sarolaner Topical Solution) for Cats, 2.8-5.5 lbs (Gold), 1 Tube

Revolution Plus Cat Protection offers a powerful monthly treatment that guards your cat against a variety of parasites like fleas, ticks, ear mites, and several worms, including heartworm. This makes it easier for you to keep your pet healthy without worrying about multiple products. It’s trusted by veterinarians as a top choice for over 25 years, which means you’re using a proven solution. Whether your cat stays indoors or likes to roam outside, this medication keeps them safe from pests that can come into your home. Plus, applying it is simple and quick, with no gloves needed, making it a hassle-free part of your pet care routine.

What We Like
Easy to apply
Vet prescribed effectiveness
No skin irritation
Multiple parasite protection
Long-lasting supply
What We Don't Like
Requires prescription
Higher price
#TOP 10

Credelio CAT Flea & Tick Chewable Tablets for Small Cats

21456143EA
Purple
2-4 lbs
Credelio CAT Flea & Tick Chewable Tablets for Small Cats Cover
Credelio CAT Flea & Tick Infestation Prevention and Treatment for Cats and Kittens 2-4 lbs. | 1-Month Supply

The Credelio CAT Flea Treatment is designed for cats and kittens weighing between 2 to 4 pounds, starting at 8 weeks old. This chewable tablet helps you quickly protect your pet, as it begins to eliminate adult fleas within just six hours. The tablet is small and flavored with vanilla and yeast, making it appealing and easy for your cat to take. Once given, it provides continuous protection for a full month, so you don’t have to worry about frequent dosing. This product offers a convenient and effective way to keep your small cat free from fleas and ticks.

What We Like
Easy oral administration
Effective flea and tick control
No strong odor
Fast-acting protection
Cheaper than vet or collar
What We Don't Like
Challenging for picky eaters
Packaging may get damaged
Buying Guide Image
Editor's Notes

During our prescription cat medication research, we found 24 prescription cat medication products and shortlisted 10 quality products. We collected and analyzed 3,108 customer reviews through our big data system to write the prescription cat medications list. We found that most customers choose prescription cat medications with an average price of $25.65.

The prescription cat medications are available for purchase. We have researched hundreds of brands and picked the top brands of prescription cat medications, including onsior, Droncit, Clavamox, Revolution Plus, Elura. The seller of top 1 product has received honest feedback from 903 consumers with an average rating of 4.7.

Written by
Janie Foster Avatar

Janie Foster is a writer & pet blogger from Los Angeles, she enjoys living with her two cats and three dogs. She owned her first dog 10 years ago and then started her personal blog to record her dog's daily life. Throughout her personal life, she has developed specialized knowledge in pet care, pet nutrition, feeding habits, and more.

Prescription Cat Medications Comparison Table

#TOP1
#TOP2
#TOP3
#TOP4
#TOP5
#TOP6
#TOP7
#TOP8
#TOP9
#TOP10
Brand Generic onsior Droncit Clavamox Revolution Plus Generic Generic Elura Revolution Plus Credelio
Brand Name Generic onsior Droncit - Revolution Plus Generic Generic Elura Revolution Plus Credelio
Target Audience Keyword Cats, house-cats Cats, dogs, house-cats Cats - house-cats Cats, Dogs, Horses Cats, Dogs, Horses Cats, house-cats house-cats house-cats
Model Name Methimazole Tablets for Animals Onsior Tablets for Cats Droncit Tablets for Cats - Revolution Plus Topical Solution for Cats Hydroxyzine HCl Tablets for Animals Dorzo Ophthalmic Solution for Animals Elura Oral Solution for Cats Revolution Plus Topical Solution for Cats Credelio for Cats
Size 100 Tablets 6mg 23mg - 5.6-11 lbs 10 mg 2% 15mL 2.8-5.5 lbs 2-4 lbs
Specific Uses for Product Thyroid Pain Parasites - flea-and-tick, heartworm Coat Eyes Kidney Disease flea-and-tick, heartworm flea-and-tick
Item Weight - 1.6 ounces - 0.5 ounces 0.2 ounces - - 0.5 ounces - 1.6 ounces
Directions - For pets weighing between 5.5-13.3 pounds, give one 6 mg tablet daily or as directed by your veterinarian. For pets weighing between 13.3-26.4 pounds, give two 6 mg tablets daily or as directed by your veterinarian. Droncit (praziquantel tablets) 23 Feline Cestocide may be administered directly per os or crumbled and mixed with the feed. The recommended dosage of praziquantel varies according to body weight. Smaller animals require a relatively larger dosage because of their higher metabolic rate. - - Hydroxyzine should be given orally as directed by your veterinarian. Please consult your veterinarian before making any changes or discontinuing the prescribed dosing schedule. Dorzolamide Ophthalmic Solution should be applied as directed by your veterinarian. Please consult your veterinarian before making any changes to the prescribed dosing schedule. Elura is administered orally at a dose of 2 mg/kg (0.9 mg/lb) or 0.1ml /kg (0.045 ml /lb) body weight once, daily. - -
FTB Score
ftb score rating icon 9.9
ftb score rating icon 9.8
ftb score rating icon 9.6
ftb score rating icon 9.5
ftb score rating icon 9.3
ftb score rating icon 9.2
ftb score rating icon 9.2
ftb score rating icon 9.2
ftb score rating icon 9.0
ftb score rating icon 8.9
Where to Buy