Best Oral Pain Relief Medications of 2025

"I really wish I had found this Orajel days ago when a particularly bad canker sore developed in my mouth. It was painful because it formed right at the top inside of my bottom lip, rubbing against my teeth. Once I finally received it, within 10 seconds, I was completely pain-free! I only applied enough to cover the sore, and I was so relieved I started laughing. I’ll always keep some on hand for anyone who has a canker sore or toothache. It's compact and easy to carry, and I don’t mind reapplying it multiple times a day!"

"I found Orajel to be a lifesaver while I waited for my dental appointment. It worked effectively to alleviate my tooth pain, making the waiting a lot more bearable. I appreciate how well it helps!"

"In the middle of a toothache, I discovered Orajel 4X. It provided instant numbness and was easy to apply with its precision applicator. I loved that I could take it anywhere. However, the relief was a bit short-lived, and the taste wasn’t the best. Still, it’s a great product for quick relief, just remember to see your dentist!"

"This product works great, just like I remember from my childhood. Fast relief and an awesome product overall!"

"I noticed they changed the application method, but I used a q-tip effectively. It provided immediate results and allowed my pain to subside without a dentist visit. The taste is a bit unusual, but it was worth it."

"I had been struggling with a mouth sore for several days, and this product provided much-needed relief. A friend asked if it was better than OraJel, which I haven't used, but based on my research, both seem similar. I can't say for sure about OraJel, but this definitely helps with gum and tooth pain!"

"After dealing with a painful cut on my cheek from my wisdom tooth, I found this product to be a lifesaver. It worked within a minute and completely eliminated my pain for about 20 minutes. I had to reapply it a few times throughout the day, but it wasn't a hassle. The taste is a bit unusual, but nothing too strong or unpleasant."

"Having used Anbesol for years, I can confidently say it always gets the job done. I recently indulged in some cherry pie, which caused a canker sore, so I needed to buy more. While I don't typically get cold sores, I recommend skipping superstitious remedies like salt, as they tend to worsen the sores instead of helping."

"I've dealt with dental issues, and Orajel has always been effective for me. The precise tip of the tube allows for easy application to painful areas. It works quickly, numbing the pain in seconds, and one application can last a few hours. The clear gel has no noticeable taste, making it perfect for discreet use. I find the tube lasts quite a while, and it's easy to carry in my bag. An excellent product and great value!"

"I recently tried Orajel for a toothache, and it transformed my experience! The relief was immediate, and the applicator is straightforward and precise. The numbing effect lasts quite a long time without causing irritation to my gums, which I appreciate. Plus, the tube is small enough to carry for emergencies. I can't recommend it enough!"

"I've used Orajel my entire life and it consistently meets my expectations. It does have a slight bitterness and the relief doesn't last long, but it does the job. I even got it for a friend with a cavity, and while he didn’t rave about it, he used the entire tube, so I think he liked it!"

"I found that this product works very quickly. I even tested it on a bug bite, and it helped with the itch too."

"While the product is good, I wonder why it lacks an applicator brush on the lid. Many similar products, like salicylic acid liquid, include one. It makes the product less convenient to travel with, as I have to rely on an additional applicator, which can be messy. The liquid is strong and does its job, but I took off two stars due to the missing applicator. It would be great if the product designers kept customer convenience in mind!"

"This Orajel 3X Maximum Strength Gel is a lifesaver. It provides remarkable relief from painful mouth sores. The gel consistency is perfect and stays in place, making it easy to use. I appreciate the compact size; it’s great for on-the-go relief!"

"While the taste isn't the best, it definitely helps with pain management. I find it worth it for the relief it provides."

"I have had sores in my mouth, and this product works wonders! It has a great value and doesn’t have a weird taste, which is a bonus for me."

"I've been using this product for years, and it works great on canker sores! I am so glad I can order it online."

"This product works immediately and dramatically reduces pain. I'm definitely buying this again."

"Using this alongside other treatments helps dull the pain and heal naturally. It's more manageable and cost-effective for me!"

"I was initially skeptical, but after trying this for my upper dentures, I found it to be magical! It took my pain away almost all day. Plus, the thickness seems to act like an additional adhesive. I will definitely keep this on hand!"

"I've been using this for six years with my dentures. It helps with those occasional sore spots and stays put when used correctly. It's a thick paste that works like an adhesive, just where needed. My family has even used it for toothaches and they love it too!"

"I was very happy with this product. It does exactly what it claims to do and provides great relief for my mouth pain!"

“After my excruciating tongue biopsy, this product provided excellent pain relief. I'm very satisfied!”

“I've been using this for years and it consistently works great. I highly recommend it!”

“I was surprised by the larger tube size I received from Amazon compared to my local store. Thank you for that!”

"This product really worked for me. It had better staying power than when I used a liquid. I was pleased with this product."

"I found that it does not last long because it wears away quickly. I preferred the tooth and gum cushions instead."

"After having 11 teeth pulled and getting a lower denture, I developed sore bumps from the denture rubbing against my gums. While waiting for my appointment, I was glad to have this product to help me out."