Best Oral Pain Relief Medications of 2026

"I've struggled with unbearable tooth pain that kept me up at night, but after using this product, I experienced instant relief and numbness within a minute. The minty taste is pleasant, and a little goes a long way—just be careful not to use too much at once to avoid numbing the tongue. This has truly been a game-changer for me!"

"After a root canal, I needed something more effective than painkillers, and this cream worked wonders. Just a small amount on my tooth and gums provided fast, localized numbing and let me get through the day comfortably. I found it best to apply with a finger for accuracy. Definitely worth it for managing pain before and after dental procedures."

"I have TMJ and a sensitive front tooth, and this numbing cream has been a lifesaver for soothing nerve pain when it flares up. It's easy to use and lets me handle pain until I can get professional treatment. Highly recommend for anyone dealing with tooth discomfort."

"I rarely write reviews, but this product truly impressed me. I had a severe canker sore that made eating and talking difficult, but after applying Orajel 3X, the pain eased almost instantly and the sore healed within days. The gel is simple to use, doesn’t sting, and has a decent taste. I highly recommend this for anyone dealing with mouth sores or irritations."

"My grandson tends to put small objects in his mouth, which sometimes leads to sores. This gel works quickly and clears up the discomfort fast."

"I had a large and painful mouth ulcer that made eating almost impossible, but after using this gel, the pain subsided enough for me to eat and drink. The mild mint flavor is gentle, and the price is worth it for the relief it provides while waiting for other medication."

"While waiting for my dental appointment, I tried this medicine and was amazed by how quickly it worked. The pain disappeared almost instantly, without any lingering taste or residue. I only needed to reapply after several hours, and even then, the discomfort was minimal. After trying multiple products over the years, I can confidently say nothing compares to this for temporary toothache relief."

"When my order arrived, I was so relieved—dealing with a severe infection and tooth pain was unbearable. As soon as I applied Anbesol, the pain was completely gone, even though I probably use more than recommended. This is now a permanent part of my first aid kit and something I’ll always keep on hand for emergencies."

"I've used this since childhood and now as an adult. It works right away, numbing the pain and giving my mouth time to heal. The taste is a bit odd, but the quick numbing effect and long-lasting relief make it worth it. I usually apply it with a q-tip, which is super convenient."

"I've used Anbesol Maximum Strength for both myself and my teenage son, and it consistently delivers immediate, powerful numbing relief for our canker sores. The gel works within seconds and allows us to eat without pain. The taste is a bit harsh, but that's a minor trade-off for the comfort it provides. While it doesn't heal sores faster, it's a must-have for anyone with mouth pain."

"As someone who frequently deals with toothaches and oral discomfort, Anbesol is my go-to solution for quick, long-lasting relief. I appreciate the thick consistency that stays in place and the convenience of the tube packaging. It's reassuring to have this product on hand while waiting to see the dentist."

"Whenever I get painful cheek bites from my wisdom teeth, this gel brings immediate relief, letting me eat and drink without agony. I just wish the numbing effect lasted a bit longer, but I still wouldn't be without it."

"I've tried both expensive and inexpensive dental temporary fillings, and honestly, this one outperformed the pricier option by far. As long as my fingers are damp, the material is easy to shape and apply. Once set overnight, it lasts nearly a week. Plus, the kit contains enough for multiple uses, so I'm covered for months. Definitely a great value and highly recommended."

"I always keep this in my first aid kit because when a dental emergency hits, it's a lifesaver. It's perfect for temporarily recementing crowns or filling gaps until I can see my dentist—especially since these issues always seem to happen outside office hours. I've relied on it for years and wouldn't be without it."

"I've used this brand before and it usually works well, but recently I received a couple of batches that just crumbled and wouldn't harden. After contacting customer service, I learned it might have been a bad batch. Thankfully, when I tried a new batch later, the product worked as expected again. I'm relieved the quality seems to be back on track."

"I've tried several brands, and this one stands out for its mild taste and thick texture. Unlike the runny generics that taste terrible and contain alcohol, this formula is far more pleasant. The most important thing is that it really helps with tooth and gum pain."

"Whenever I get dental discomfort, I reach for this brand because it works within seconds and numbs the pain effectively. The tube design makes it super easy to apply exactly where I need it, and I love that it's clear with no bitter aftertaste. A little goes a long way, and the tube lasts me for months. It's my go-to for fast relief."

"This was my first time using a product like this, and it worked well for my minor gum and tooth pain. The gel gives immediate relief and lasts about an hour—just long enough for my regular pain meds to kick in. Application can be a bit challenging, but overall, I'm satisfied and will use it again if needed."

"I've tried several products for mouth sores, but Zilactin B stands out with its powerful numbing and protective coating. While the taste isn't great, the fact that I can finally eat even soft foods without pain makes it totally worth it. Just give it a few minutes to set, and it works wonders."

"Whenever I get canker sores, this product is my go-to for all-night relief. It does sting a bit at first, but the numbing happens quickly and lasts for hours. Cleanup is easy, and the slight bitterness is manageable."

"Dealing with a trauma fibroma, I started using Zilactin B together with other rinses. It effectively dulls the pain and fits my busy schedule. My tip: dry the area first with dental gauze before applying. It dries quickly and makes a noticeable difference."

"I've always struggled with sensitive gums and mouth sores because I wear dentures, but this mouthwash has been a game changer for me. It provides relief and comfort, and I find it especially helpful for anyone dealing with problematic teeth. Absolutely worth every penny."

"Whenever I get a sore in my mouth, this is my go-to solution. I love that it has a pleasant flavor without any harsh medicinal aftertaste. Out of everything I've tried, this product works best for me."

"After a tooth extraction, I had a spot on my gum that just wouldn't heal. On my first day using this, I noticed a major improvement in both appearance and comfort. There's a bit of tingling, but that's normal and totally fine. I just wish I'd tried it sooner."

"I’ve tried several products for mouth sores, but this one stands out for its quick pain relief and gentle, cooling sensation. I use it at night after brushing, and it’s given me better results than a dental visit—plus, it’s much cheaper!"

"After struggling with a sore in my mouth that wouldn’t heal due to my diabetes, I was amazed by this product. Within hours, I felt protected and pain-free, without any annoying numbness. The taste is mild, and I’m definitely keeping more on hand."

"This gel has been a lifesaver for soothing the irritation from my braces. When I use it on sore spots right away, the area heals in about three days. I’m planning to buy more as long as I need braces."