Best Cetylpyridinium Chloride Mouthwashes of 2026

Elisa Drew Avatar
Elisa Drew
Last Updated: Jan 11, 2026

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Cetylpyridinium Chloride mouthwashes are a type of antiseptic mouthwash that can help fight bad breath, plaque buildup, and gingivitis. These mouthwashes contain a powerful antiseptic ingredient called cetylpyridinium chloride, which helps kill bacteria in the mouth and prevent the formation of plaque. Some brands of Cetylpyridinium Chloride mouthwash also contain fluoride, which can help strengthen tooth enamel and prevent cavities. These mouthwashes are easy to use and can be a great addition to your daily oral hygiene routine. However, it's important to use them as directed and not swallow the mouthwash.

At a Glance: Our Top Picks

TheraBreath Healthy Gums Oral Rinse Cover #TOP 1
TheraBreath Healthy Gums Oral Rinse
ftb score rating icon 9.8
Listerine Zero Alcohol Mouthwash Cover #TOP 2
Listerine Zero Alcohol Mouthwash
ftb score rating icon 9.7
Colgate Peroxyl Antiseptic Mouthwash, 1.5% Hydrogen Peroxide, Mild Mint - 500ml Cover #TOP 3
Colgate Peroxyl Antiseptic Mouthwash, 1.5% Hydrogen Peroxide, Mild Mint - 500ml
ftb score rating icon 9.5

Top 10 Cetylpyridinium Chloride Mouthwashes

#TOP 1

TheraBreath Healthy Gums Oral Rinse

Healthy Gums
TheraBreath Healthy Gums Oral Rinse Cover
TheraBreath Healthy Gums Oral Rinse, Antigingivitis, Clean Mint Flavor, Dentist Formulated to Help Prevent Gingivitis and Support Gum Health, Alcohol Free, 16 Fl Oz (Pack of 2)

TheraBreath Healthy Gums Oral Rinse is an effective solution to fight bacteria and common symptoms of gum disease. This periodontist-formulated mouthwash contains CPC and xylitol to neutralize the decay process and kill germs linked to gum disease, gingivitis, plaque and tartar buildup, and bad breath. The 24-hour oral rinse is alcohol-free, gentle on sensitive gums, and certified vegan, kosher, and gluten-free. It is also exceptional for treating gum-related problems associated with menopause, pregnancy, and other medical conditions.

What We Like
Gentle, alcohol-free formula
Long-lasting fresh breath
Supports gum health
Clean mint flavor
Convenient double pack

Listerine Zero Alcohol Mouthwash

PPAX1248850
Cool Mint
Listerine Zero Alcohol Mouthwash Cover
Listerine Cool Mint Alcohol Free Mouthwash, Oral Rinse Kills 99.9% of Germs That Cause Bad Breath, for Fresh Breath & Less Intense Taste, No Alcohol Burn Cool Mint Flavor, 1 L

Get fresher and cleaner breath with Listerine Zero Alcohol Mouthwash. This 1 L bottle of Cool Mint flavor mouthwash kills 99.9% of bad breath germs without the overpowering taste of alcohol. Its less intense oral care formula leaves your mouth feeling clean and refreshed after use. With a four-week supply, use twice a day for maximum results and protection from bad breath germs.

What We Like
Gentle alcohol-free formula
Long-lasting fresh breath
No burning sensation
Effective germ-killing action
Suitable for sensitive gums

Colgate Peroxyl Antiseptic Mouthwash, 1.5% Hydrogen Peroxide, Mild Mint - 500ml

10035000320299
Blue
Colgate Peroxyl Antiseptic Mouthwash, 1.5% Hydrogen Peroxide, Mild Mint - 500ml Cover
Colgate Peroxyl Antiseptic Mouthwash and Mouth Sore Rinse, 1.5% Hydrogen Peroxide, Mild Mint - 500ml, 16.9 Fluid Ounces

Colgate Peroxyl Antiseptic Mouthwash is a mouth rinse that helps cleanse and promote healing of minor oral wounds, such as oral sores and irritations. Its oxygenating action removes debris and soothes minor gum inflammation from dental procedures, dentures, and orthodontic appliances. With a mild mint flavor, this alcohol-free formula is perfect for those with sensitive mouths.

What We Like
Fast canker sore relief
Gentle foaming action
Mild mint flavor
No alcohol or burning
Effective for mouth wounds

Crest Pro Health Multi-Protection Mouthwash

PPAX1253890
Crest Pro Health Multi-Protection Mouthwash Cover
Crest Pro-Health Multi-Protection Mouthwash with CPC, Clean Mint, 1L (33.8 fl oz), Crest Mouthwash, Gingivitis Treatment

Crest Mouthwash is a germ-killing mouthwash that helps you maintain a healthier mouth. It fights against plaque and gingivitis, reduces gum inflammation, and bleeding gums. It is alcohol-free, so you won't have to deal with the burning sensation of other mouthwashes. With 2x daily use, it provides 24-hour protection. Rinsing every day can help prevent gingivitis, and the mouthwash also helps eliminate millions of germs that cause bad breath. Incorporating Crest Mouthwash into your daily oral care routine can lead to a significant reduction in gingivitis compared to brushing with regular toothpaste.

What We Like
Alcohol-free formula
Long-lasting freshness
Gum health support
Large value-sized bottle
No burning sensation

Crest Pro-Health Advanced Mouthwash

37000943228
Crest Pro-Health Advanced Mouthwash Cover
Crest Pro-Health Advanced Mouthwash, Alcohol Free, Extra Whitening, Energizing Mint Flavor, 946 mL (32 fl oz)

Crest Whitening Mouthwash is a mouthwash that provides multiple benefits to improve your oral health. It safely whitens teeth by removing surface stains when used with brushing. It also strengthens enamel to prevent cavities. The mouthwash kills bad breath germs, giving you fresh breath all day. As it is alcohol-free, there is no burning sensation in your mouth. The Crest Whitening Mouthwash comes in an energizing mint flavor, which leaves you with a refreshing sensation. By using this mouthwash regularly, you can maintain good oral hygiene and achieve a brighter smile.

What We Like
Alcohol-free
Effective whitening formula
Refreshing mint flavor
Convenient packaging
Helps remove bacteria and stains
#TOP 6

TheraBreath Deep Clean Mouthwash

697029010556
White
TheraBreath Deep Clean Mouthwash Cover
TheraBreath Deep Clean Mouthwash, Antiseptic Benefits, Fresh Mint Flavor, Dentist Formulated, Alcohol Free, 16 fl oz (Pack of 2)

TheraBreath Mouthwash offers a refreshing fresh mint flavor while effectively combating bad breath and oral health issues. This dentist-formulated mouthwash kills 99.9% of germs linked to bad breath, plaque, and gingivitis, ensuring you can smile with confidence. Unlike many mouthwashes, it is alcohol-free, which means you won’t experience any burning sensation while rinsing. It is also free from harmful additives like dyes, sulfates, and parabens, making it a safer choice for your daily oral care routine. With its vegan and gluten-free certification, this mouthwash caters to diverse dietary needs.

What We Like
Alcohol-free formula
Eliminates bad breath germs
Gentle on the mouth
Vegan and gluten-free
#TOP 7

Listerine Gum Therapy Antiplaque & Gingivitis Mouthwash

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Blue
Listerine Gum Therapy Antiplaque & Gingivitis Mouthwash Cover
Listerine Gum Therapy Antiplaque & Anti-Gingivitis Mouthwash, ADA Accepted Oral Rinse Helps Reverse Early Gingivitis Signs Like Bleeding Gums, 4X Healthier Gums in 3 Weeks vs Brushing Alone, Mint, 1 L

The Listerine Gum Therapy Antiplaque & Gingivitis Mouthwash is an ADA Accepted mouthwash that effectively cleans below the gum line for a clean mouth and fresh breath with a refreshing glacier mint flavor. It promotes gum health by helping reverse the signs of early gum disease such as bleeding, redness, and inflammation, resulting in 4-times healthier gums in 3 weeks versus brushing alone when used twice a day. The #1 dentist recommended brand also helps remove plaque, one of the leading causes of gum disease, and is 5X more effective than flossing for plaque reduction. Made with essential oils, this mouthwash offers 24-hour germ protection and is perfect for promoting whole mouth clean.

What We Like
Highly effective in reversing signs of early gingivitis
Provides a refreshing and clean taste
Stimulates and toughens gums
#TOP 8

Parodontax Active Gum Health Mouthwash, Mint

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Parodontax Active Gum Health Mouthwash, Mint Cover
Parodontax Active Gum Health Mouthwash, Antiplaque and Antigingivitis Mouthwash, Mint, 3x16.9 Fl Oz

Parodontax Active Gum Health Mouthwash is an alcohol-free mouthwash that comes in a pack of three 16.9 fl oz bottles. It is formulated with CPC to target plaque bacteria and kills 99.9% of them. The oral rinse also forms an antibacterial shield to help prevent plaque bacteria build-up and bleeding gums. It has a mint flavor for fresh breath and should be used daily for best results.

What We Like
Reduces bleeding gums
Fresh feeling and alcohol-free
Effective in just a few days
#TOP 9

ACT Restoring Zero Alcohol Fluoride Mouthwash

ACT
041167097830
Green
ACT Restoring Zero Alcohol Fluoride Mouthwash Cover
ACT Restoring Zero Alcohol Fluoride Mouthwash 33.8 fl. oz. Strengthens Tooth Enamel, Mint Burst

ACT Restoring Zero Alcohol Fluoride Mouthwash is a 33.8 fl. oz. bottle of alcohol-free mouthwash, designed to give 4 benefits in 1. It strengthens tooth enamel, remineralizes soft spots, helps prevent tooth decay, and freshens breath. Anticavity rinses like ACT Restoring Mouthwash can help reduce cavities up to 70% more than brushing with a fluoride toothpaste alone. It is the dentist recommended fluoride brand.

What We Like
Alcohol-free formula
Strengthens tooth enamel
Long-lasting fresh breath
Gentle on sensitive mouths
Large bottle size
#TOP 10

hello Antigingivitis Mouthwash

61038858
Blue
hello Antigingivitis Mouthwash Cover
Hello Peace Out Plaque, Antigingivitis Alcohol Free Mouthwash, Natural Mint with Aloe Vera and Coconut Oil, Fluoride Free, Vegan, SLS Free and Gluten Free, 16 Ounce (Pack of 3)

Hello Mouthwash is a pack of three 16-ounce bottles of hello naturally healthy antigingivitis mouthwash. It is a STAR Magazine 2018 A-List Beauty Award winner and is formulated to prevent plaque and gingivitis, freshen breath and provide an awesome taste. What sets Hello Mouthwash apart is that it is alcohol-free, contains no artificial sweeteners, flavors, dyes, or SLS/Sulfates. It is also vegan, cruelty-free (Leaping Bunny Certified) and made in the USA. With Hello Mouthwash, you can brush and greet freely, knowing that you are using a natural mint mouthwash with aloe vera and coconut oil that is gentle yet effective in promoting oral health.

What We Like
Alcohol-free
No artificial ingredients
Vegan and cruelty-free
Buying Guide Image
Editor's Notes

During our cetylpyridinium chloride mouthwash research, we found 24 cetylpyridinium chloride mouthwash products and shortlisted 10 quality products. We collected and analyzed 653,430 customer reviews through our big data system to write the cetylpyridinium chloride mouthwashes list. We found that most customers choose cetylpyridinium chloride mouthwashes with an average price of $10.89.

The cetylpyridinium chloride mouthwashes are available for purchase. We have researched hundreds of brands and picked the top brands of cetylpyridinium chloride mouthwashes, including TheraBreath, Listerine, Colgate, Crest, Parodontax. The seller of top 1 product has received honest feedback from 384 consumers with an average rating of 4.7.

Written by
Elisa Drew Avatar

Elisa Drew is a really professional copywriter specializing in baby products with five years of experience working as a pediatrician once. She has published a series of baby books purchased by over thirty thousand people in the United States.