Best Preservative-Free Eye Drops For Dry Eyes of 2025

iVIZIA Sterile Lubricant Eye Drops are a moisturizing and preservative-free solution designed for dry eye relief. The unique formulation includes hydrating polymers, moisturizing hyaluronic acid, and trehalose for long-lasting moisture. The patented ABAK bottle allows for easy dispensing drop-by-drop, without streaming, and is contact lens friendly. The bottle is also ergonomic, easy to open, hold, and squeeze.

Systane Hydration eye drops provide long-lasting relief for dry eyes with advanced hydration from hyaluronate. These preservative-free drops are safe for use with all contact lenses and extra moisturizing for sensitive eyes. Clinically proven to protect and soothe dry eye symptoms.

TheraTears Dry Eye Therapy Lubricant Eye Drops, Preservative Free, provide immediate, long-lasting relief of dry eye symptoms. Created by an ophthalmologist after 18 years of research, these drops contain the 5 vital electrolytes found in natural tears and are preservative free for sensitive eyes. Customers praise the product for its soothing effects and its ability to provide relief from dry eye symptoms. However, some customers have noted that the single-use vials can be sharp and poke the eye if not handled carefully.

Ocusoft Retaine MGD Ophthalmic Emulsion is a preservative-free solution that moisturizes, lubricates, and protects moderate to severe dry eyes. This product utilizes Nova orb technology that effectively delivers ingredients through electrostatic attraction, which provides long-lasting relief. The emulsion's hypo tonicity adds moisture by lowering the salt concentration of tears, while the lipid component lubricates and protects the surface of the eye.

TheraTears Extra Dry Eye Therapy Lubricant Eye Drops provide extraordinary relief for dry eyes by rehydrating, protecting against further irritation, and supporting a natural tear pH level. These lubricating eye drops contain the 5 vital electrolytes found in natural tears, and are preservative-free for sensitive eyes. They come in a convenient, single-use vials sealed in foil pouches to ensure freshness, and are recommended by eye doctors. TheraTears is perfect for at home and on the go, and is part of the TheraTears Dry Eye Therapy line for more complete dry eye symptom relief.

BLINK Eye Drops offer immediate and lasting relief for dry eyes. The Hyaluronate ingredient provides quick hydration by thickening and stabilizing the tear film. The twist-and-pull tab design ensures easy application, making it convenient for daily use. These preservative-free drops reduce discomfort with each blink, soothing and hydrating your eyes instantly.

Optase Eye Drops are designed to provide lasting relief for those suffering from moderate to severe dry eye symptoms. These preservative-free drops contain glycerin and high-quality ingredients that work together to hydrate your eyes and enhance tear quality. With 30 convenient single-dose vials, you can easily carry them wherever you go, ensuring you have quick access to soothing relief. Plus, they are safe to use with contact lenses, making them an ideal choice for anyone needing on-the-go eye care.

TheraTears Eye Drops provide quick and lasting relief for dry eyes, making them essential for anyone suffering from discomfort. These preservative-free drops offer a unique silky hydration that helps soothe your eyes. With the inclusion of five essential electrolytes found in natural tears, they effectively restore the balance of salt in your eyes, alleviating dryness. The convenient single-use vials come in a foil pouch, ensuring each drop remains fresh and easy to use whenever you need relief.

Optase MGD Advanced Eye Drops offer relief from moderate to severe symptoms of Meibomian Gland Dysfunction (MGD) and severe dry eye. The preservative-free formula is contact lens safe and features moisturizing Demet technology that provides superior lubrication without causing blurriness. The advanced bottle technology allows for up to 300 doses and maintains sterility for up to three months. Optase MGD is the expert recommended 3-step regimen for tackling dry eyes, especially MGD.

This Oasis TEARS Plus Lubricant Eye Drops come in 30 count sterile disposable containers and is recommended for moderate to severe dry eye symptoms. It can be used during day or night and is preservative-free, providing safe and long-lasting relief for dry eyes. This product falls under the category of Dry Eye Relief Products.