Best Cold Sore Treatments for Lips of 2025

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Cold sores are a common affliction that can be both painful and unsightly. Fortunately, there are a variety of treatments available that can help alleviate symptoms and speed up the healing process. Some popular options include antiviral creams, which are applied directly to the affected area, as well as over-the-counter pain relievers and topical ointments. Additionally, natural remedies such as tea tree oil, aloe vera, and lysine supplements have been shown to be effective in reducing the duration and severity of cold sores. It's important to consult with a healthcare professional before beginning any new treatment regimen, as some products may interact with existing medications or have potential side effects.
At a Glance: Our Top Picks
Top 10 Cold Sore Treatments for Lips
Campho Phenique Cold Sore Treatment Gel
Campho Phenique Cold Sore Treatment Gel is specially formulated to provide instant relief for cold sores and fever blisters. It relieves pain and itch, while helping to prevent infection and promoting healing. Suitable for adults and children over 2 years old, this gel formula is easy to apply and should be stored at room temperature.
Quantum Health Lip Clear Lysine+ Cold Sore Treatment Ointment
Quantum Health Lip Clear Lysine+ Cold Sore Treatment Ointment is an award-winning formula that provides instant relief by reducing pain, itching, and burning. It helps in cutting the cold sore healing time in half and inhibits the activity of arginine that triggers the cold sore outbreak. Its innovative cold sore fighting formula includes menthol that brings fast pain relief and lysine that helps in the reduction of cold sore symptoms. It is highly effective and is recommended for optimal results when used with Super Lysine+ Tablets.
Acculip Cold Sore Patch
The Acculip Lip Patch offers an effective solution for cold sores with its unique hydrocolloid design enriched with lysine, zinc, and calendula. This patch creates a moist environment that speeds up healing while protecting the sore from external irritants. You can apply it discreetly, allowing you to go about your day without the mess of creams. Additionally, it helps reduce the appearance of cold sores, making it easier for you to feel confident, even under makeup. With these benefits, you can heal your cold sores while maintaining your natural look.
Herpecin L Lip Balm Stick 30 SPF with Lysine
Herpecin-L Lip Balm is a reliable solution for those who suffer from cold sores, fever blisters, and chapped lips. Its unique formula includes lysine, Vitamins C, B6, and E, lemon balm, and SPF 30 protection. With this lip balm, you can treat your lips to soothing relief from dryness, sun blisters, and cold sores. It creates a barrier to protect your lips against the sun's harmful UV rays, which can increase your risk of sun cancer, chapped lips, early skin aging, and damaged skin that can promote the development of cold sores. Its dimethicone and lysine ingredients help relieve and protect painful cracking of lips and promote healing of cold sores without numbing or drying.
Abreva 10% Docosanol Cold Sore Treatment - 0.07 oz Tube x 2
Abreva 10% Docosanol Cold Sore Treatment is a portable solution that can heal fever blisters in 2.5 days. The cream penetrates deep into the skin to tackle cold sores at their source, and it is clinically proven to shorten the duration of symptoms such as tingling, pain, burning, and itching. The product is packaged in a convenient tube for on-the-go cold sore treatment.
Mederma Cold Sore Healing Patch - Conceals and Protects - 15 ct
Mederma Cold Sore Healing Patch is an ultra-thin hydrocolloid gel that helps relieve pain, reduce blistering, and prevent scabbing of cold sores. The discreet patch creates a moist environment that promotes fast healing.
Herstat+ Cold Sore Treatment 2g
Herstat+ Cold Sore Cream is designed to provide quick relief from the discomfort of cold sores. It contains 3% Propolis Extract and Camphor, which work together to ease itching and burning sensations on your lips. This natural treatment targets pain effectively, allowing you to apply it at any stage of an outbreak. Additionally, it soothes and moisturizes your lips, helping to alleviate dryness and cracking. With a subtle appearance, it's perfect for on-the-go use, ensuring you can address your cold sore whenever needed.
Clear Probiotics Lip and Skin Health
Clear Probiotics Lip and Skin Health is a probiotic supplement that promotes healthy and beautiful lips and skin. Its special formula contains powerful ingredients like lysine and vitamin C that prevent the production of arginine in the body, the common trigger for lip and mouth blisters. This supplement also balances out the bacteria responsible for outbreaks and improves gut health and microbiome. The vegan and non-GMO formula is 3rd party tested for purity, potency, and safety.
Herpecin-L Lip Protectant
Herpecin-L Lip Balm is an everyday protection lip balm that offers relief and protection against cold sores, fever blisters, and chapped lips. It is formulated with lysine, Vitamins C, B6, and E, lemon balm, and SPF 30. With its soothing and moisturizing properties, Herpecin-L Lip Balm helps to create a barrier against the sun's harmful UV rays, preventing sunburn and protecting your lips from early skin aging. Additionally, it promotes the healing of cold sores without numbing or drying. Find real relief from herpes-related cold sores with Herpecin-L Lip Balm.
Quantum Health Lip Clear Cold Sore Bandage, 12 Ct
The Quantum Health Lip Clear Invisible Cold Sore Bandage uses hydrocolloid technology to maintain skin moisture and reduce contact with the cold sore, which may reduce transmission. It also shields from irritants that exacerbate cold sore symptoms and stays in place for maximum protection. The bandage is compatible with makeup, making it easy to conceal cold sores. For optimal results, use with Lip Clear Lysine+ Cold Sore Treatment ointment to promote faster resolution.
During our cold sore treatment for lips research, we found 24 cold sore treatment for lips products and shortlisted 10 quality products. We collected and analyzed 266,354 customer reviews through our big data system to write the cold sore treatments for lips list. We found that most customers choose cold sore treatments for lips with an average price of $13.52.
The cold sore treatments for lips are available for purchase. We have researched hundreds of brands and picked the top brands of cold sore treatments for lips, including Campho-Phenique, Quantum, Acculip, Herpecin-L, Abreva. The seller of top 1 product has received honest feedback from 385 consumers with an average rating of 4.7.

Bonnie Salem is a stay-at-home mother with two-year-old twins and has spent almost half of her life surrounded by baby products. As a mother and a professional copywriter, she has an insightful and unique eye for researching products suitable for infants. Bonnie Salem is an expert in health and nutrition who lives with her family in New Jersey. She has over 15 years of working experience in an institute of medicine after graduating from the University of Toronto. She is highly interested in personal health and wellness.