Best Anesthetic & Antiseptic Oral Rinses of 2026

Canker-X Mouthwash is a fast-acting and effective oral rinse that provides quick pain relief and promotes healing for various mouth sores. This clinically tested benzocaine-free and alcohol-free mouthwash is ideal for treating canker sores, cheek bites, mouth burns, gum sores, abrasions from braces and dentures, and other types of mouth sores. It works by forming a micro-thin, protective coating over the sores, soothing them, and blocking irritants like food and drink. With the goodness of Aloe Vera, Sodium Hyaluronate, and Polyvinylpyrrolidone (PVP), it provides up to 6 hours of pain relief. The easy-to-use measurement cap ensures the right amount is used, and the pleasant taste makes it suitable for multiple mouth sores. Safe for both children (6+ years) and adults, Canker-X Mouthwash is a reliable solution for fast pain relief and healing.

TheraBreath Healthy Gums Oral Rinse is formulated to support gum health, combat bad breath, and prevent oral problems such as gingivitis, plaque, and tartar buildup. It is dentist-formulated and contains CPC. The premium oral care line of TheraBreath includes toothpaste, mouthwash, breath sprays, tonsil stone kits, and more. The professional-grade products can help address halitosis, cavity prevention, and gum disease. The brand has been trusted since 1994.

Orajel Alcohol-Free Antiseptic Rinse is an anesthetic and antiseptic oral rinse that kills bacteria and promotes the healing of sores inside the mouth, all while featuring a refreshing mint flavor. Additionally, it is alcohol-free, making it a gentler option for those with sensitive mouths.

MetaQil Mouthwash is the first-of-its-kind oral rinse scientifically designed to alleviate metallic, bitter, and unusual tastes caused by chemotherapy, radiation, COVID-19, medication, or GERD. Its unique formula contains eight natural ingredients, including vitamin E, menthol, peppermint, and spearmint, which provide instant cooling relief without any burning sensation. Its natural sweeteners and alcohol-free, gluten-free, and sugar-free formulation make it a convenient and safe choice for daily use. Simply swish 1 tsp (approx. 5 mL) of refreshing oral rinse for 30 seconds in the mouth, and then spit out for instant relief. Packaged in an 8 oz bottle, it is perfect for on-the-go use as a breath freshener and mouth moisturizer.

The TheraBreath Overnight Rinse offers a calming chamomile mint flavor that makes your nighttime oral care routine more pleasant and refreshing. The large 16 fl oz bottle ensures you have plenty of rinse to use regularly, making it easy to maintain fresh breath every night. Designed specifically for use before bed, this rinse helps keep your breath feeling clean and fresh throughout the night. Plus, it contains carefully chosen ingredients that are free from genetically modified organisms and gluten, giving you peace of mind about what you're putting in your mouth.

S.T.37 Antiseptic Liquid by NUMARK LABORATORIES INC is a general antiseptic solution for household use. It quickly kills common pathogenic bacteria, making it an effective solution for minor cuts, abrasions, and burns. Unlike other antiseptics, S.T.37 is gentle to use, causing little to no stinging or burning sensation. It even soothes irritated areas, providing comfort and relief. Another advantage is that it doesn't stain the skin or leave any unpleasant odor. With S.T.37 Antiseptic, you can easily keep your skin clean and protected without any hassle or discomfort.

TheraSol Concentrate is a versatile antiseptic oral rinse that can be used as a mouthwash, an irrigation solution for shallow pockets, and for deep pockets where normal irrigation can't reach. It helps to maintain good oral hygiene by rinsing around the gumline and irrigating hard-to-reach areas.

The Seacall Pain Relief Mouthwash is designed to help you manage oral discomfort effectively. It provides fast relief for pain caused by bleeding gums, ulcers, and other common mouth issues, helping you feel better quickly. The fresh mint flavor not only soothes your mouth but also leaves a refreshing taste that lasts. Using this mouthwash is simple: just swish 10-20ml for three minutes after brushing, twice daily. Plus, it’s clinically tested for safety and effectiveness, so you can trust it to support your oral health while promoting faster healing of sores and gum problems.